Initial institutional experience of uncooled single-antenna microwave ablation for large hepatocellular carcinoma

Liang, Po-Chin; Lai, Hong‐Shiee; Shih, Tiffany Ting-Fang; Wu, Chien-Hui; Huang, Kai‐Wen

doi:10.1016/j.crad.2015.01.011

Cited by 10 publications

(8 citation statements)

References 18 publications

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“…Liang et al [27] reported an incidence of 2.6% for major complications after MWA. Furthermore, a major complication rate of 9.2% was reported for medium and large HCCs (3-7 cm) treated with RFA and MWA [9], and 14.3% for large HCCs (5-8 cm) treated with MWA [28]. In our study, only three (3.7%) patients developed major complications, which was a significant improvement over previous reports.…”

Section: Discussionsupporting

confidence: 45%

Percutaneous microwave ablation of 5-6 cm unresectable hepatocellular carcinoma: local efficacy and long-term outcomes

Shen

Wang

et al. 2016

International Journal of Hyperthermia

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Section: Discussionsupporting

confidence: 45%

Percutaneous microwave ablation of 5-6 cm unresectable hepatocellular carcinoma: local efficacy and long-term outcomes

Shen

Wang

et al. 2016

International Journal of Hyperthermia

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“…To date, only a few studies 15 17 19 20 have investigated the prognosticators of RFS and OS in patients with HCC who received MWA as an initial treatment, and the majority of these studies suffered from some shortcomings such as small cohort size 15 19 20 21 22 , small number of variables to be analyzed 21 22 , restriction to tumors ina special range of sizes 15 20 21 22 or in special areas 17 . Our study, on the contrary, included 221 treatment-naïve patients who received percutaneous MWA as an initial therapy and recorded up to 22 variables for survival analysis.…”

Section: Discussionmentioning

confidence: 99%

Microwave ablation of hepatocellular carcinoma as first-line treatment: long term outcomes and prognostic factors in 221 patients

Wang

Chi

et al. 2016

Sci Rep

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This retrospective study aimed at evaluating the long-term outcomes and prognostic factors of microwave ablation (MWA) as a first-line treatment for hepatocellular carcinoma (HCC). 221 consecutive patients receiving MWA in our center between October 11, 2010 and December 31, 2013 were enrolled. Technique effectiveness was evaluated one month post-ablation. Initial complete ablation (CA1st) was gained in 201 (90.95%) patients, secondary CA (CA2nd) in 8 (3.62%) patients and the remaining 12 (5.43%) patients suffered from incomplete ablation (IA2nd) after two sessions of MWA. Patients with tumor size >5 cm were less likely to gain CA1st. Procedure-related complications were recorded and no procedure-related death occurred. 22 (10.4%) complications occurred with 8 (3.8%) being major ones. Tumor characteristics (size, number, location) do not significantly influence complication rates. After a median follow-up of 41.0 (ranging 25.0–63.5) months, the median RFS and OS was 14.0 months (95% CI: 9.254–18.746) and 41.0 months (95% CI: 33.741–48.259) respectively. Multivariate analysis identified two significant prognosticators (levels of alpha fetal protein [AFP] and gamma-glutamyl transpeptidase [GGT]) of RFS and five significant prognosticators (tumor number, tumor size, AFP, GGT and recurrence type) of OS. In conclusion, MWA provides high technique effectiveness rate and is well tolerated in patients with HCC as a first-line treatment.

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“…Another clinical system varies frequency (902-928 MHz) to manage reflected power and relies on an uncooled antenna with low power. Clinical studies show that when the system was used for 15-60 min at 10-32 W to treat 23 liver tumours of 4-7 cm in diameter, there was an average of 2.5 treatments needed per tumour [119]. Furthermore, in another study with the same system, tumours larger than 3 cm were only partially ablated [120].…”

Section: Tissue Model Considerationsmentioning

confidence: 99%

Interstitial microwave treatment for cancer: historical basis and current techniques in antenna design and performance

Ryan¹,

Brace

2016

International Journal of Hyperthermia

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The use of microwaves (MW) for thermal cancer treatment began in the late 1970s. At first, hyperthermia was induced by using single antennas applied interstitially. This was followed by arrays of multiple interstitial antennas driven synchronously at 915 or 2450 MHz. This early work focused on hyperthermia as an adjuvant therapy, but more recently has evolved into a thermally ablative monotherapy. Increased power required to thermally ablate tissues required additional developments such as internally cooled antennas. Larger tumours have also been ablated with MW antenna arrays activated synchronously or non-synchronously. Numerical modelling has provided clinical treatment planning guidance and device design insight throughout this history. MW thermal therapy systems, treatment planning, navigation and image guidance continue to evolve to provide better tools and options for clinicians and patients in order to provide targeting optimisation with the goal of improved treatment for the patient and durable cancer eradication. This paper reviews the history and related technological developments, including antenna design, of MW heating for both hyperthermia and ablation.

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Initial institutional experience of uncooled single-antenna microwave ablation for large hepatocellular carcinoma

Cited by 10 publications

References 18 publications

Percutaneous microwave ablation of 5-6 cm unresectable hepatocellular carcinoma: local efficacy and long-term outcomes

Percutaneous microwave ablation of 5-6 cm unresectable hepatocellular carcinoma: local efficacy and long-term outcomes

Microwave ablation of hepatocellular carcinoma as first-line treatment: long term outcomes and prognostic factors in 221 patients

Interstitial microwave treatment for cancer: historical basis and current techniques in antenna design and performance

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