Intraoperative Low-volume Acute Normovolemic Hemodilution in Adult Open-heart Surgery

Casati, Valter; Speziali, Giovanni; D'Alessandro, Cesare; Cianchi, Clara; Grasso, Antonietta; Spagnolo, Salvatore; Sandrelli, Luca

doi:10.1097/00000542-200208000-00013

Cited by 58 publications

(37 citation statements)

References 28 publications

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“…More recent studies have been published, with negative results. 65,66 However, in these studies, low-volume ANH was added to a well-defined blood conservation approach aiming at decreasing perioperative blood losses by the use of cell saving techniques and the administration of aprotinin or tranexamic acid. As a result, the hematocrit (or the hemoglobin concentration) before leaving the operating room was similar in the control and ANH patients.…”

Section: Results From the Literaturementioning

confidence: 99%

Acute Normovolemic Hemodilution in Cardiac Surgery

Linden

Sakr

2005

Transfus Alt Transfus Med

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Section: Results From the Literaturementioning

confidence: 99%

Acute Normovolemic Hemodilution in Cardiac Surgery

Linden

Sakr

2005

Transfus Alt Transfus Med

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“…~3-~7 Hohn et at. conducted a prospective randomized study of 77 patients undergoing cardiac operations under moderate hypothermia, which showed 15 and they also found that low-volume ANH lacked efficacy. These were properly planned, randomized prospective trials, but the subjects underwent only relatively low invasive procedures, in terms of both surgical procedures performed and CPB conditions.…”

Section: Discussionmentioning

confidence: 99%

Beneficial effect of acute normovolemic hemodilution in cardiovascular surgery

Taketani

Motomura

Toyokawa

et al. 2005

Jpn J Thorac Caridovasc Surg

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“…ANH is accomplished by drawing a unit of the patient's blood at the beginning of the surgery while administering 500 ml of colloid solution, and returning the autologous blood at the end of the surgery. This technique is used routinely in cardiac surgery and was tried in other major operations as part of blood conservation strategies with the purpose of reducing homologous blood transfusion [12][13][14]. We hypothesized that ANH could assist in lowering blood pressure during the surgery, thereby reducing the need for hypotensive drugs or other agents that decrease blood pressure.…”

Section: Introductionmentioning

confidence: 99%

Acute normovolemic hemodilution in patients undergoing head and neck surgery: a prospective randomized trial

Leiser¹,

Barák²,

Kubichka³

et al. 2013

J Anesthesiol Clin Sci

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Background: Acute normovolemic hemodilution (ANH) is a technique used during anesthesia for major operations, usually to reduce homologous blood transfusion. We studied ANH in large head and neck operations, for which controlled hypotension is required. We selected those procedures since ANH addresses issues of both decreasing blood pressure and minimizing blood loss. Methods: This is a prospective study of 45 adult patients who underwent elective large maxillofacial resections and orthognathic operations, which duration was predicted to be 3 hours or more. The patients were randomly divided into 2 groups: ANH group (19 patients) and a control group (26 patients). In ANH group one unit of blood was drawn from the patient after the induction of general anesthesia and was returned at the end of the surgery. Target mean blood pressure during the surgery was 30% below the patient's usual pressure, with a minimum of 50 mm Hg. Various hemodynamic and laboratory parameters as well as postoperative outcome were monitored. Results: Patients in the ANH group receive significantly lower dose of fentanyl comparing to the control group (p=0.02), and had higher blood pressure at the end of the surgery. No significant difference was found between the groups regarding age, gender, weight, ASA class, duration of surgery, usage of hypotensive drugs and blood transfusion during the surgery. Conclusions: ANH is a safe technique to use in anesthesia for head and neck operations; it facilitates using a smaller dose of fentanyl and assists in resuming higher blood pressure at the end of surgery.

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Intraoperative Low-volume Acute Normovolemic Hemodilution in Adult Open-heart Surgery

Abstract: In patients undergoing elective open-heart surgery, low-volume ANH showed lack of efficacy in reducing the need for allogeneic transfusions and postoperative bleeding.

Cited by 58 publications

References 28 publications

Acute Normovolemic Hemodilution in Cardiac Surgery

Acute Normovolemic Hemodilution in Cardiac Surgery

Beneficial effect of acute normovolemic hemodilution in cardiovascular surgery

Acute normovolemic hemodilution in patients undergoing head and neck surgery: a prospective randomized trial

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