Intraoperative Label‐Free Photoacoustic Histopathology of Clinical Specimens

Baik, Jin Woo; Kim, Hyojin; Son, Myeongjoo; Choi, Junwon; Kim, Kwang Gi; Baek, Jeong‐Heum; Park, Yeon Ho; An, Jungsuk; Choi, Hae Young; Ryu, Seon Young; Kim, Jin Young; Byun, Kyunghee; Kim, Chulhong

doi:10.1002/lpor.202100124

Cited by 58 publications

(43 citation statements)

References 31 publications

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“…In conclusion, the high spatial resolution and contrast offered by OAT imaging make it a powerful modality for noninvasive tracking of microrobots. Their treatment efficiency could additionally be monitored by using molecular imaging capabilities of multispectral OAT ( 72 – 74 ). Our results thus pave the way toward in vivo translation of medical microrobots in intravascular environments.…”

Section: Discussionmentioning

confidence: 99%

Real-time 3D optoacoustic tracking of cell-sized magnetic microrobots circulating in the mouse brain vasculature

et al. 2022

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Mobile microrobots hold remarkable potential to revolutionize health care by enabling unprecedented active medical interventions and theranostics, such as active cargo delivery and microsurgical manipulations in hard-to-reach body sites. High-resolution imaging and control of cell-sized microrobots in the in vivo vascular system remains an unsolved challenge toward their clinical use. To overcome this limitation, we propose noninvasive real-time detection and tracking of circulating microrobots using optoacoustic imaging. We devised cell-sized nickel-based spherical Janus magnetic microrobots whose near-infrared optoacoustic signature is enhanced via gold conjugation. The 5-, 10-, and 20-μm-diameter microrobots are detected volumetrically both in bloodless ex vivo tissues and under real-life conditions with a strongly light-absorbing blood background. We further demonstrate real-time three-dimensional tracking and magnetic manipulation of the microrobots circulating in murine cerebral vasculature, thus paving the way toward effective and safe operation of cell-sized microrobots in challenging and clinically relevant intravascular environments.

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Section: Discussionmentioning

confidence: 99%

Real-time 3D optoacoustic tracking of cell-sized magnetic microrobots circulating in the mouse brain vasculature

et al. 2022

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“…[13][14][15] By tuning the wavelength, PAI can distinguish different samples based on their optical absorption spectra. [16][17][18][19] Due to the complementary structural and molecular functional information obtained, overlaid PAUS imaging (PAUSI) has been widely used for monitoring biological responses in various biomedical studies. [20][21][22][23][24] Several commercial PAUS platforms have been used in biomedical applications.…”

Section: Impact Statementmentioning

confidence: 99%

Photoacoustic imaging systems based on clinical ultrasound platform

Park

Lee

Han

et al. 2022

Exp Biol Med (Maywood)

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Photoacoustic imaging has drawn a significant amount of attention due to its unique capacity for functional, metabolic, and molecular imaging, which is achieved by the combination of optical excitation and acoustic detection. With both strengths of light and ultrasound, photoacoustic images can provide strong optical contrast at high ultrasound resolution in deep tissue. As photoacoustic imaging can be used to visualize complementary information to ultrasound imaging using the same data acquisition process, several studies have been conducted on combining photoacoustic imaging with existing clinical ultrasound systems. This review highlights our development of a photoacoustic/ultrasound dual-modal imaging system, various features and functionalities implemented for clinical translation, and preclinical/clinical studies performed by using the systems.

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“…Photoacoustic imaging (PAI) excels in visualizing biomolecules by exploiting their high optical absorption without requiring any exogenous contrast agent [1] , [2] , [3] , [4] , [5] , [6] , [7] . Thus, the capability of PAI renders it useful for imaging blood vessels and monitoring hemodynamics by highlighting hemoglobin at visible wavelengths [8] .…”

Section: Introductionmentioning

confidence: 99%