Fully integrated photoacoustic microscopy and photoplethysmography of human in vivo

Ahn, Jae-Sung; Baik, Jin Woo; Kim, Yeonggeon; Choi, Karam; Park, Jeongwoo; Kim, Hyojin; Kim, Jin Young; Nam, SungHyun; Kim, Chulhong

doi:10.1016/j.pacs.2022.100374

Cited by 43 publications

(38 citation statements)

References 42 publications

(43 reference statements)

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“…In 2022, Kim et al attempted a study on the photoplethysmography (PPG) system with the explicitness of photoacoustic microscopy of blood vessels in a 532 nm wavelength pulsed laser (AWAVE 532-1W-10K, Advanced Optowave, Ronkoma, NY, USA) [ 24 ]. The PPG sensor and PAM signal results were analyzed from data of approximately 60 s, which is more than the actual PPG analysis level (10 s) [ 24 ]. In this type of analysis, there are problems, such as the cost and resolution of motion artifacts; however, it is necessary to pay attention to new applications.…”

Section: Laser Wavelengths and Applications For Photoacoustic Effectsmentioning

confidence: 99%

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Optical Light Sources and Wavelengths within the Visible and Near-Infrared Range Using Photoacoustic Effects for Biomedical Applications

2022

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The photoacoustic (PA) effect occurs when sound waves are generated by light according to the thermodynamic and optical properties of the materials; they are absorption spectroscopic techniques that can be applied to characterize materials that absorb pulse or continuous wave (CW)-modulated electromagnetic radiation. In addition, the wavelengths and properties of the incident light significantly impact the signal-to-ratio and contrast with photoacoustic signals. In this paper, we reviewed how absorption spectroscopic research results have been used in applying actual photoacoustic effects, focusing on light sources of each wavelength. In addition, the characteristics and compositions of the light sources used for the applications were investigated and organized based on the absorption spectrum of the target materials. Therefore, we expect that this study will help researchers (who desire to study photoacoustic effects) to more efficiently approach the appropriate conditions or environments for selecting the target materials and light sources.

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Section: Laser Wavelengths and Applications For Photoacoustic Effectsmentioning

confidence: 99%

“…( E ) Comparison of the heart rates. Reprinted from J.Ahn et al, Photoacoustics, 2022, 27: 100374 [ 24 ], with permission of Elsevier.…”

Section: Figurementioning

confidence: 99%

Optical Light Sources and Wavelengths within the Visible and Near-Infrared Range Using Photoacoustic Effects for Biomedical Applications

2022

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“…However, PAM is limited in imaging depth (~1 mm); thus, it is primarily applied to imaging superficial areas, including the ear, eye, brain, and skin in small animals [ 16 , 17 , 18 , 19 , 20 , 21 ]. The imaging depth of PAI can be enhanced (up to ~10–20 mm) by sacrificing its spatial resolution (~100–500 μm) [ 22 ]. In such configurations, the light is moderately focused or even diffused in biological tissue, and the resolution of images is determined by the acoustic focal zone of the US transducers.…”

Section: Introductionmentioning

confidence: 99%

Whole-Body Photoacoustic Imaging Techniques for Preclinical Small Animal Studies

Kye

Song

Kim

et al. 2022

Sensors

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Photoacoustic imaging is a hybrid imaging technique that has received considerable attention in biomedical studies. In contrast to pure optical imaging techniques, photoacoustic imaging enables the visualization of optical absorption properties at deeper imaging depths. In preclinical small animal studies, photoacoustic imaging is widely used to visualize biodistribution at the molecular level. Monitoring the whole-body distribution of chromophores in small animals is a key method used in preclinical research, including drug-delivery monitoring, treatment assessment, contrast-enhanced tumor imaging, and gastrointestinal tracking. In this review, photoacoustic systems for the whole-body imaging of small animals are explored and summarized. The configurations of the systems vary with the scanning methods and geometries of the ultrasound transducers. The future direction of research is also discussed with regard to achieving a deeper imaging depth and faster imaging speed, which are the main factors that an imaging system should realize to broaden its application in biomedical studies.

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“…Photoacoustic (PA) images are reconstructed using ultrasound (US) signals generated by localized thermal expansion and contraction induced by the irradiation of light-absorbing imaging targets using a pulsed laser. As intrinsic optical absorbers present in human tissues, such as oxy-hemoglobin (HbO 2 ), deoxy-hemoglobin (Hb), lipids, melanin, and water, exhibit unique light absorption coefficients depending on the laser wavelength, PA imaging can emphasize the spectroscopic analysis of biological tissues [ 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 ]. In addition, a spectral unmixing process using multi-wavelength PA images enables the extraction of concentrations of specific light absorbers and captures consequent functional information, such as total hemoglobin concentration, hemoglobin oxygen saturation (sO 2 ), and lipid concentration [ 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 ].…”

Section: Introductionmentioning

confidence: 99%

Motion Compensation for 3D Multispectral Handheld Photoacoustic Imaging

Yoon

Lee

Shin³

et al. 2022

Biosensors

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Three-dimensional (3D) handheld photoacoustic (PA) and ultrasound (US) imaging performed using mechanical scanning are more useful than conventional 2D PA/US imaging for obtaining local volumetric information and reducing operator dependence. In particular, 3D multispectral PA imaging can capture vital functional information, such as hemoglobin concentrations and hemoglobin oxygen saturation (sO2), of epidermal, hemorrhagic, ischemic, and cancerous diseases. However, the accuracy of PA morphology and physiological parameters is hampered by motion artifacts during image acquisition. The aim of this paper is to apply appropriate correction to remove the effect of such motion artifacts. We propose a new motion compensation method that corrects PA images in both axial and lateral directions based on structural US information. 3D PA/US imaging experiments are performed on a tissue-mimicking phantom and a human wrist to verify the effects of the proposed motion compensation mechanism and the consequent spectral unmixing results. The structural motions and sO2 values are confirmed to be successfully corrected by comparing the motion-compensated images with the original images. The proposed method is expected to be useful in various clinical PA imaging applications (e.g., breast cancer, thyroid cancer, and carotid artery disease) that are susceptible to motion contamination during multispectral PA image analysis.

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Fully integrated photoacoustic microscopy and photoplethysmography of human in vivo

Cited by 43 publications

References 42 publications

Optical Light Sources and Wavelengths within the Visible and Near-Infrared Range Using Photoacoustic Effects for Biomedical Applications

Optical Light Sources and Wavelengths within the Visible and Near-Infrared Range Using Photoacoustic Effects for Biomedical Applications

Whole-Body Photoacoustic Imaging Techniques for Preclinical Small Animal Studies

Motion Compensation for 3D Multispectral Handheld Photoacoustic Imaging

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