Intraoperative detection of 5-aminolaevulinic acid-induced protoporphyrin fluorescence in lymphonode metastases after oral administration

Itoh, Yoshio; Ninomiya, Yoshiharu; Henta, Tetsuro; Tajima, S.; Ishibashi, Akira

doi:10.1046/j.1365-2133.2000.03383.x

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2000

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“…Since this report, photodynamic techniques with ALA have been widely studied in various medical fields, including dermatology (8). In our institution, the photodynamic technique with ALA has been used since 1997 not only for treatment of malignant tumors (9-12) but also for diagnosis (13,14) and treatment of benign cutaneous disorders (9,15), based on the great advantage that the photosensitizing effects disappear within 24 hours (16).…”

Section: Introductionmentioning

confidence: 99%

Topical δ‐Aminolevulinic Acid‐Based Photodynamic Therapy for Japanese Actinic Keratoses

Itoh

Ninomiya

Henta

et al. 2000

The Journal of Dermatology

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Based on the opinion that 5-aminolevulinic acid-based photodynamic therapy (ALA-PDT) may be disadvantageous to Oriental patients with dark skin, including Japanese, because the competing chromophore melanin inhibits the photochemical reaction, we assessed the therapeutic effects when Japanese AK were treated with ALA-PDT. Fifty-three lesions in ten patients were followed up for over one year. The cure rates of AK on the face including the neck and on extremities were 81.8% and 55.6%, respectively. The results were approximately the same cure rates as those reported for AK in Caucasian patients. However, a larger number of treatment sessions were required. In the red light range, incoherent light including 630 nm and 670 nm is superior to 630 nm laser light.

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