Topical δ‐Aminolevulinic Acid‐Based Photodynamic Therapy for Japanese Actinic Keratoses

Itoh, Yoshiyasu; Ninomiya, Yoshiharu; Henta, Tetsuro; Tajima, S.; Ishibashi, Akira

doi:10.1111/j.1346-8138.2000.tb02218.x

Cited by 36 publications

(47 citation statements)

References 24 publications

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“…depression of liver function and hypotension) that are observed upon systemic administration. Therefore, since 1990, when Kennedy et al used this therapy for skin disorders (23), ALA has been widely used for treatment and diagnosis of various superficial diseases, and many studies have been performed (3,10,(24)(25)(26)(27). However, since ALA is administered locally as an application that has low permeability, the production of protoporphyrin IX (PPIX) is limited to the surface and ALA is considered to be ineffective for deepseated nodular tumors (10).…”

Section: -------------------------------------------------Table IV Smentioning

confidence: 99%

Synergistic interaction of 5-aminolevulinic acid-based photodynamic therapy with simultaneous hyperthermia in an osteosarcoma tumor model

Yanase¹,

Nomura²,

Matsumura³

et al. 2006

Int J Oncol

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Abstract. In this study, the effectiveness and mechanism of combination therapy of 5-aminolevulinic acid-based photodynamic therapy (ALA-PDT) with simultaneous hyperthermia (HT) on human-derived osteosarcoma in vivo were examined. A tumor model was prepared by subcutaneously implanting human osteosarcoma into nude mice and local injection of ALA was selected as the administration route. This study demonstrated that both ALA-PDT and the combination of ALA-PDT with HT exhibited significant inhibitory effects on tumor growth. In the group with high total energy, the growth inhibition rates of tumor were 52.3% in ALA-PDT, and 27.3% in ALA-PDT with simultaneous HT (PDT+HT), and the synergetic index was 1.76, demonstrating that the inhibitory effect on tumor growth in ALA-PDT was significantly increased by simultaneous use of HT. In the histological findings, after ALA-PDT, necrosis was observed in the area from the surface to a depth of 2 mm, and only a slight effect was confirmed in deeper layers. On the other hand, after PDT+HT, necrosis was observed in layers even deeper than 2 mm below the surface. Furthermore, based on the immunohistochemical findings of the expression of carbonic anhydrase IX, while weak expression of CAIX was observed after ALA-PDT in an area relatively close to the surface, a positive area extended to the deeper layers after PDT+HT compared with ALA-PDT. In conclusion, PDT+HT demonstrated a significant inhibitory effect on tumor growth of human-derived osteosarcoma, and a synergistic interaction of simultaneous HT. This suggests the possibility that ALA-PDT is useful, not only for the treatment of superficial tumors but also for deep-seated mesenchymal tumors, such as osteosarcoma. Furthermore, the mechanism of the synergistic interaction suggested that ALA-PDT was effective in the deep area of tumors due to the increase of blood flow by mild hyperthermia.

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Section: -------------------------------------------------Table IV Smentioning

confidence: 99%

Synergistic interaction of 5-aminolevulinic acid-based photodynamic therapy with simultaneous hyperthermia in an osteosarcoma tumor model

Yanase¹,

Nomura²,

Matsumura³

et al. 2006

Int J Oncol

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“…Similar findings have already been described in previous studies and may be due to the fact that the lesions on the extremities are in general thicker and more keratotic, consequently leading to poorer penetration of the photosensitizing agent, which may subsequently result in a poorer response to therapy. 12,17,18,22,23 In the present report, most of the patients tolerated the method well and satisfaction rates were favorable to the use of the technique. This shows that the use of PDT with ALA and diode lights is an alternative that is well-tolerated by patients.…”

Section: Discussionmentioning

confidence: 64%

“…These therapeutic options involve different degrees of efficacy and may be followed by different side effects such as secondary infection, slow healing, pain or discomfort, scarring and changes in pigmentation. [12][13][14][15] In 1978, Dougherty et al 16 were the first to use PDT clinically. From that time onwards, it has been used to treat different types of tumor.…”

Section: Discussionmentioning

confidence: 99%

“…In dermatology and, more specifically, for the treatment of AKs, open studies using PDT with δALA and non-coherent light in patients with AKs of the face and scalp reported cure rates of 71-100% following a single application. 7,12,[17][18][19] In a study conducted by this group using PDT with δALA and a non-coherent experimental light source, clinical cure was achieved in 65.7% of AKs treated with a single application. 10 In addition, multicenter randomized studies A B…”

Section: Discussionmentioning

confidence: 99%

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Terapêutica fotodinâmica com ácido delta-aminolevulínico e luz de diodos em ceratoses actínicas

Ritter

Kuhl

Lenhardt

et al. 2010

An. Bras. Dermatol.

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BACKGROUND: Photodynamic therapy is a form of treatment in which a photosensitizing substance is applied to tissue and activated by a light source at a specific wavelength, thus selectively destroying cells. New light sources are being evaluated for use in the treatment of actinic keratoses. OBJECTIVES: To evaluate the efficacy of photodynamic therapy with delta-aminolevulinic acid using a light emitting diode device as a light source in the treatment of actinic keratoses of the face and upper limbs. METHODS: Eighteen patients with actinic keratoses of the face or upper limbs received an application of a 20% delta-aminolevulinic acid cream and were submitted to diode light irradiation at a wavelength of 630 nm. RESULTS: A total of 328 actinic keratoses were treated, obtaining complete cure in 210 (64.0%) after 24 weeks. Lesions situated on the back of the hands were clinically cured in 49.2% of cases compared to 81.4% in the cases of lesions in other areas. There was no record of any severe adverse effects and patient satisfaction with the results was high. CONCLUSION: Photodynamic therapy with a diode light emitting source proved effective and well-tolerated for the treatment of actinic keratoses, with results similar to those reported in the literature with other light sources. Keywords: Keratosis; Photobiology; Photochemotherapy Resumo: FUNDAMENTOS: A terapêutica fotodinâmica é técnica de tratamento em que se aplica uma substân-cia fotossensibilizante nos tecidos ativada por uma fonte de luz de comprimento de onda específico, gerando destruição celular seletiva. Estudam-se novas fontes de luz que possam ser usadas no tratamento de ceratoses actínicas. OBJETIVOS: Avaliar a efetividade da terapêutica fotodinâmica com ácido delta-aminolevulínico utilizando como fonte de luz um aparelho emissor de luz de diodos no tratamento de ceratoses actínicas de face e membros superiores. MÉTODOS: Dezoito pacientes com ceratoses actínicas na face ou membros superiores realizaram uma aplicação de creme de ácido delta-aminolevulínico a 20% e foram submetidos à exposição de luz de diodos, comprimento de onda de 630 nm. RESULTADOS: Foram tratadas 328 ceratoses actínicas, obtendo-se cura clínica completa em 210 (64,0%) após 24 semanas. Lesões do dorso das mãos apresentaram cura clínica completa em 49,2%; nas demais áreas esse valor foi de 81,4%. Não houve registro de efeitos adversos graves, e obteve-se bom grau de satisfação dos pacientes com os resultados. CONCLUSÃO: A terapêutica fotodinâmica com fonte de emissão de luz de diodos mostrou-se eficaz e bem tolerada para tratamento de ceratoses actínicas, com resultados semelhantes aos encontrados na literatura utilizando outras fontes luminosas.

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“…Esse acúmulo de ALA nas lesões pode ser comprovado por meio da observação de fluorescência vermelha com lâmpada de Wood em quarto escuro; o que também serve como diagnóstico e marcação de margem para cirurgia 150 .…”

Section: Mecanismo De Ação Da Terapia Fotodinâmicaunclassified

Estudo da pele humana fotoenvelhecida após tratamento com terapia fotodinâmica associada ao ácido 5-delta-aminolevulínico tópíco: avaliação imunoistoquímica, do colágeno e do tecido elástico

Ferolla¹

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Topical δ‐Aminolevulinic Acid‐Based Photodynamic Therapy for Japanese Actinic Keratoses

Cited by 36 publications

References 24 publications

Synergistic interaction of 5-aminolevulinic acid-based photodynamic therapy with simultaneous hyperthermia in an osteosarcoma tumor model

Synergistic interaction of 5-aminolevulinic acid-based photodynamic therapy with simultaneous hyperthermia in an osteosarcoma tumor model

Terapêutica fotodinâmica com ácido delta-aminolevulínico e luz de diodos em ceratoses actínicas

Estudo da pele humana fotoenvelhecida após tratamento com terapia fotodinâmica associada ao ácido 5-delta-aminolevulínico tópíco: avaliação imunoistoquímica, do colágeno e do tecido elástico

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