“…Represented by the fundamental demonstration in 1977 by Jobsis, 1 noninvasive spectroscopic assessment of the tissue functionality using diffuse photon in the visible and near-infrared spectra has been applied with various levels of clinical readiness to disease diagnosis, [2][3][4] treatment monitoring, [5][6][7] and surgery regime. [8][9][10][11] Spectral measurement of the diffuse photon remitted from the object surface, which is referred to as diffuse reflectance spectroscopy (DRS), 12 diffuse optical spectroscopy (DOS), 13,14 or functional near-infrared spectroscopy, 15 is among the simplest photon-based techniques suitable for in vivo organsite application 13 when taking the conveniences offered by fiberbased contact approach for photon illumination and collection. Equally applicable in the noncontact or remote mode for the assessment of spectral constituents of an object, 16 DRS is also indispensable in the quality assurance of encapsulation of powdered therapeutic compounds 17,18 and agricultural surveying of some fruits.…”