Intraocular (vitreoretinal) lymphoma following primary testicular lymphoma

Grange, Landon; Jacobs-El, Naima; Wiley, Henry; Kurup, Shree K.; Chan, Chi‐Chao; Sen, H. Nida

doi:10.1016/j.jcjo.2013.03.024

Cited by 3 publications

(6 citation statements)

References 7 publications

(4 reference statements)

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“…Ocular relapse up to 11 years following the testicular lymphoma diagnosis has been reported. 6 Both of the patients reported here previously received intrathecal methotrexate—case 1 for CNS prophylaxis, and case 2 for treatment of CNS recurrence—yet both later developed vitreoretinal lymphoma, suggesting that prior intrathecal therapy may not prevent ocular relapse. Long term monitoring of testicular lymphoma patients with regular dilated fundus examinations should be considered due to the possibility of late relapse.…”

Section: Discussionmentioning

confidence: 84%

“… Reference No. of cases Findings Time from testicular lymphoma to VRL (years) Treatment of VRL Davis et al 2 1 Details not provided 4.5 Orbital radiation Wallace et al 3 2 Vitritis, subretinal infiltrates, RPE mottling ∼4–8 Intravitreal MTX and dexamethasone Aliferis et al 4 1 Vitritis, pinpoint creamy retinal lesions 10 Local radiotherapy Pe'er et al 5 1 Elevated white-yellow subretinal lesion 3 Intravitreal MTX, simultaneous systemic MTX to prevent systemic recurrence Grange et al 6 1 Creamy subretinal infiltrate, pinpoint infiltrates, pigmentary changes 11 Intravitreal MTX, systemic MTX and rituximab Reimens et al 7 9 Details not provided 0–10 Various MTX = methotrexate; RPE = retinal pigment epithelium; VRL = vitreoretinal lymphoma. …”

Section: Discussionmentioning

confidence: 99%

“… 1 There have been only occasional reports of vitreoretinal lymphoma following testicular lymphoma. 2 , 3 , 4 , 5 , 6 , 7 In order to raise increased awareness about this important association, we describe two cases of ocular relapse of testicular lymphoma that simulated the presentation of primary vitreoretinal lymphoma with vitritis and subretinal infiltrates. To our knowledge, this is the first report of ocular relapse of primary testicular lymphoma to include optical coherence tomography findings.…”

Section: Introductionmentioning

confidence: 99%

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Vitreoretinal lymphoma following primary testicular lymphoma: Report of two cases and review of the literature

Alsberge

Johnson

2021

American Journal of Ophthalmology Case Reports

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Purpose To report two cases of vitreoretinal lymphoma that developed following primary testicular lymphoma and review the literature. Observations Two men, one age 66 and the other age 77, both with a history of diffuse large B-cell testicular lymphoma, diagnosed one and three years previously, respectively, presented with vitritis and yellow-white subretinal infiltrates. Diagnostic vitrectomy in both cases revealed diffuse large B-cell lymphoma. Systemic work up in both cases showed no evidence of disease relapse elsewhere. Each were treated with intravitreal methotrexate injections. Conclusions Vitreoretinal lymphoma can occur following primary testicular lymphoma, and may mimic primary vitreoretinal lymphoma. Monitoring of patients with a history of testicular lymphoma with regular dilated fundus examinations should be considered.

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Section: Discussionmentioning

confidence: 84%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Vitreoretinal lymphoma following primary testicular lymphoma: Report of two cases and review of the literature

Alsberge

Johnson

2021

American Journal of Ophthalmology Case Reports

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“…The histological confirmation of DLBCL with cytology and immunohistochemistry was performed using an incisional biopsy sample of the uveal tissue. Cases of ocular involvement following primary testicular lymphoma have previously been reported internationally [4][5][6][7]9]. All these cases presented as vitreoretinal lymphoma and were confirmed using a diagnostic vitrectomy specimen of the vitreous fluid; the subtype of the lymphoma was DLBCL.…”

Section: Discussionmentioning

confidence: 85%

“…However, ocular relapse of testicular diffuse large B-cell lymphoma (DLBCL), which is the most common subtype of PTL [3], has not been previously reported. Although ocular involvement of testicular DLBCL as vitreoretinal lymphoma has been globally reported [4][5][6][7], there are no cases of ocular relapse in uveal tissue. Here, we report the first case of relapsed testicular DLBCL in the eye with histologically confirmed involvement of the uveal tissue.…”

Section: Introductionmentioning

confidence: 99%

Relapse of Ocular Lymphoma following Primary Testicular Diffuse Large B-cell Lymphoma

Kwon

Lee

2023

J Retin

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Purpose: To describe the first case of ocular relapse of primary testicular B-cell lymphoma in a South Korean male. Case summary: A 60-year-old man with a history of left testicular diffuse large B-cell lymphoma diagnosed four years prior to this presentation complained of decreased vision in his right eye for the past two months despite treatment for uveitis. He had a history of brain relapse of diffuse large B-cell lymphoma two years prior and had been in secondary complete remission for two years. Ophthalmologic examination revealed uveitis with a pseudohypopyon and a mass-like lesion on the iris. Incisional biopsy of the iris mass revealed diffuse large B-cell lymphoma. A systemic work up showed no evidence of lymphoma relapse elsewhere, and additional systemic chemotherapy was planned. Conclusions: This case is the first report of ocular involvement of testicular diffuse large B-cell lymphoma in South Korea. Clinicians should be aware of ocular relapse in patients with a history of testicular lymphoma who complain of eye symptoms.

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