Intraocular soluble intracellular adhesion molecule-1 correlates with subretinal fluid height of diabetic macular edema

Zhu, Dan; He, Zhonghu; Wang, Chunyan; Yang, Da-Yong

doi:10.4103/0301-4738.111184

Cited by 18 publications

(7 citation statements)

References 26 publications

(30 reference statements)

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“…This passive diffusion at the level of RPE may become even more important particularly when active pumping function of the RPE was impaired. In one basic research, the concept of Starling's rule may perhaps have a role to explain the observation that intracellular adhesion molecule-1 (ICAM-1), an immunoglobulin superfamily upregulated by VEGF, was inversely related to SRF height [ 31 ]. Another supportive evidence showed reduced central macular thickness after meal compared with that of before meal, suggesting the glucose effect on the fluid distribution across the retina [ 32 ].…”

Section: Discussionmentioning

confidence: 99%

Systemic Associations with Residual Subretinal Fluid after Ranibizumab in Diabetic Macular Edema

Tsai

Hsieh

Shen

et al. 2017

Journal of Ophthalmology

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Purpose To investigate the impact of systemic diseases on the occurrence of subretinal fluid (SRF) in diabetic macular edema (DME) and prognostic factors for residual SRF following three consecutive monthly intravitreal ranibizumab. Methods Ninety-seven eyes from 68 patients with DME who completed 3 consecutive monthly injections of ranibizumab were enrolled. Systemic parameters mainly included chronic kidney disease (CKD), hypertension, HbA1c, and insulin dependence. Renal parameters for CKD were serum creatinine, estimated glomerular filtration rate (eGFR), and serum albumin. Ocular factors were baseline central macular thickness (CMT), severity of diabetic retinopathy (DR), and status of panretinal photocoagulation (PRP). Results Chronic kidney disease had significant correlation with baseline SRF (R = 0.397, p < 0.001 after partial correlation with adjustment for age and DR severity). As for CKD, lower serum albumin, but not eGFR or serum creatinine, was associated with baseline presence of SRF (p = 0.026, p = 0.08 and p = 0.53, resp., after adjustment for age and DR severity). Overall, lower eGFR and lower HbA1c values, contrary to popular belief, predicted the presence of residual SRF following intravitreal injections (p = 0.016 and p < 0.001, resp.). Conclusions Tight sugar control and poorer baseline kidney function may slow the resorption of SRF after anti-VEGF injections in patients with DME in the short term.

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Section: Discussionmentioning

confidence: 99%

Systemic Associations with Residual Subretinal Fluid after Ranibizumab in Diabetic Macular Edema

Tsai

Hsieh

Shen

et al. 2017

Journal of Ophthalmology

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“…We can nonetheless confirm the utility of SD-OCT in identifying parameters that can be predictive of better and longer response to DEX-I, thus reinforcing the need to further study combinations of SD-OCT and metabolic biomarkers. One such candidate for study is intracellular adhesion molecule 1, which has been shown to correlate with subretinal fluid height in DME [37].…”

Section: Discussionmentioning

confidence: 99%

Baseline SD-OCT characteristics of diabetic macular oedema patterns can predict morphological features and timing of recurrence in patients treated with dexamethasone intravitreal implants

et al. 2020

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Aims To evaluate the timing and spectral-domain optical coherence tomography (SD-OCT) features of diabetic macular oedema (DME) recurrence according to baseline OCT patterns in patients treated with dexamethasone implant (DEX-I). Methods This is a retrospective observational study (72 eyes/65 patients). Best-corrected visual acuity, timing of DME recurrence, and SD-OCT pattern [intraretinal cysts (IRC), IRC plus subretinal fluid (mixed), external limiting membrane (ELM), ellipsoid (IS/OS) layer integrity] were assessed at baseline and monthly until first DME recurrence. Results Forty-two (58.3%) and 30 (41.6%) DME eyes had an IRC and mixed DME pattern at baseline, respectively. Twentyfour out of thirty mixed eyes (80%) relapsed without subretinal fluid. At baseline, mixed eyes showed similar changes in ELM and IS/OS (60 and 76.6% of eyes, respectively) versus IRC eyes (42.8 and 80.9% of eyes). After DME recurrence, more mixed eyes at baseline showed ELM and IS/OS changes (63.3 and 86.6%) than IRC eyes (50 and 76.2%). 33.3% of mixed eyes had DME recurrence at ≥ 6 months from first DEX-I implant versus 19% of IRC eyes. Conclusions Mixed DME eyes were treated with DEX-I relapse later and more frequently without subretinal fluid than IRC eyes. SD-OCT characteristics of different DME patterns at baseline can predict morphological features and timing of DME recurrence.Publisher's Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

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“…31 The importance of RPE to DR development depends on the photoreceptor abnormalities present early in the DR pathogenesis. [32][33][34][35] Another important feature of increasing outer retinal barrier resistance is the fluid accumulation in the subretinal space, particularly in the macular area, [36][37][38][39] which is a hallmark of diabetic macular edema and has important clinical relevance. Thus, the RPE role in DR deserves further investigation and could represent a possible site for novel therapeutic approaches.…”

Section: Discussionmentioning

confidence: 99%

δ Opioid Receptor Agonism Preserves the Retinal Pigmented Epithelial Cell Tight Junctions and Ameliorates the Retinopathy in Experimental Diabetes

Faria

Duarte

Simó

et al. 2019

Invest. Ophthalmol. Vis. Sci.

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Citation: Lopes de Faria JM, Duarte DA, Simó R, et al. d opioid receptor agonism preserves the retinal pigmented epithelial cell tight junctions and ameliorates the retinopathy in experimental diabetes. Invest Ophthalmol Vis Sci. 2019;60:3842-3853. https://doi.org/10.1167/iovs.19-26761PURPOSE. Outer blood retinal barrier breakdown is a neglected feature of diabetic retinopathy (DR). We demonstrated that the agonism of the d opioid receptor (DOR) by epicatechin preserves the tight junction proteins in ARPE-19 cells under diabetic conditions. Presently, we aimed to evaluate the possible role of the DOR on the maintenance of tight junction of RPE layer and on the early markers of experimental DR.METHODS. DR markers and external retinal tight junction proteins were evaluated in CL57B diabetic mice submitted to intravitreous injection of short hairpin RNA (shRNA)-DOR (10 8 transducing units [TU]/mL) treated or not with DOR agonist (0.05 g/animal/d of epicatechin in drinking water) for 16 weeks. The presence of DOR in human retina from postmortem eyes from diabetic and nondiabetic donors were also performed.RESULTS. DOR is present in RPE layer and in neuro retina. The treatment with DOR agonist prevented the upregulation of the early markers of retinopathy (glial fibrillary acidic protein, VEGF) and the downregulation of pigment epithelium-derived factor, occludin, claudin-1, and zonula occludens-1 tight junction expressions. The silencing of DOR in retina of diabetic mice partially abolished the protective effects of epicatechin. In human retina specimens, DOR is present throughout the retina, similarly in nondiabetic and diabetic donors.CONCLUSIONS. This set of experiments strongly indicates that the DOR agonism preserves RPE tight junctions and reduces the early markers of retinopathy in model of diabetes. These novel findings designate DOR as a potential therapeutic tool to treat DR with preservation of the RPE tight junction proteins.

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Intraocular soluble intracellular adhesion molecule-1 correlates with subretinal fluid height of diabetic macular edema

Cited by 18 publications

References 26 publications

Systemic Associations with Residual Subretinal Fluid after Ranibizumab in Diabetic Macular Edema

Systemic Associations with Residual Subretinal Fluid after Ranibizumab in Diabetic Macular Edema

Baseline SD-OCT characteristics of diabetic macular oedema patterns can predict morphological features and timing of recurrence in patients treated with dexamethasone intravitreal implants

δ Opioid Receptor Agonism Preserves the Retinal Pigmented Epithelial Cell Tight Junctions and Ameliorates the Retinopathy in Experimental Diabetes

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