Intraocular pressure in Japanese diabetic patients

Matsuoka, Masato; Ogata, Nahoko; Matsuyama, Kayako; Yoshikawa, Tadanobu; Takahashi, Kanji

doi:10.2147/opth.s33131

Cited by 11 publications

(7 citation statements)

References 29 publications

(57 reference statements)

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“…Although several risk factors such as HbA1C have been suggested, the causative factors associated with high IOP in diabetic patients have not yet been elucidated. Albuminuria is a well-known marker of nephropathy in patients with type 2 diabetes [5] , [8] , [18] . Recent studies have emphasized the role of albuminuria as an indicator of cardiovascular outcome and a marker of vascular endothelial dysfunction [19] – [23] .…”

Section: Discussionmentioning

confidence: 99%

Association between Urinary Albumin Excretion and Intraocular Pressure in Type 2 Diabetic Patients without Renal Impairment

2014

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BackgroundTo assess the relationship between urinary albumin excretion and intraocular pressure (IOP) in type 2 diabetes patients without renal impairment.MethodsWe explored the effects of albuminuria on high IOP in 402 non-glaucomatous type 2 diabetes without renal impairment who participated in the 2011 Korean National Health and Nutrition Examination Survey (KNHANES). Multiple logistic regression analysis was used to assess the relationship between log-transformed albumin/creatinine ratio (ACR) tertiles and an IOP of ≥18 mmHg after adjusting for age, gender, hypertension, body mass index, triglycerides, area of residence, and education level.ResultsSubjects with a high IOP ≥18 mmHg were more likely to be current smokers (P = 0.038), heavy drinkers (P = 0.006), and to have high systolic blood pressure (P = 0.016), triglycerides (P = 0.008), and a higher log-transformed ACR (P = 0.022).In multivariate regression analysis, ACR tertile was associated with the prevalence of high IOP significantly (P = 0.022). The associations between ACR tertiles and high IOP were significant in overweight patients and those with abdominal obesity (P = 0.003 and 0.003, respectively). In contrast, there were no associations in the subgroup of patients who were not overweight and those without abdominal obesity (P = 0.291 and 0.561, respectively).ConclusionsUrinary albumin excretion is associated with high IOP in the type 2 diabetes population without renal insufficiency. The effect of the albuminuria on IOP was evident in a subgroup of patients with components of metabolic syndrome.

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Section: Discussionmentioning

confidence: 99%

Association between Urinary Albumin Excretion and Intraocular Pressure in Type 2 Diabetic Patients without Renal Impairment

2014

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“…Also there was no significant difference between the diabetic retinopathy grades (p value=0,183 or some aspects of glucose metabolism could affect IOP. 9 Diabetes mellitus is known to cause microvaskular damage and may affect the autoregulatory action of the blood vessels in the retina and optic nerve. Diabetes has been found to be associated with elevated IOP and has therefore been suggested to be a possible risk factor for glaucoma, particulary open-angle glaucoma.…”

Section: Resultsmentioning

confidence: 99%

Correlation Between Ocular Rigidity With Intraocular Pressure In Patient With Type 2 Diabetes Mellitus

Iqbal¹,

Sari²,

Amin³

et al. 2019

sjo

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ABSTRACT Introduction and Objectives: Diabetes mellitus (DM) is known to have a biomechanical effect on tissue. High blood glucose concentrations that lead to increased production of free radical intermediates causes ocular rigidity (OR) changes. This change can effect intraocular pressure (IOP) in patients with type 2 DM. This study to determine correlation between ocular rigidity with IOP in patients with type 2 DM. Methods: A cross-sectional study with a correlation test design of OR with IOP in type 2 DM patients was conducted in RSUP dr. Mohammad Hoesin Palembang from January until June 2018. Eighty eye samples consist of 60 type 2 DM and 20 control group. IOP examination was performed using a Goldmann applanation tonometer and OR measurements using schiotz tonometer with two loads then assessed in Friedenwald differential tables. Result: There was a significant correlation between diabetic retinopathy and OR (p=0,000). There was a significant correlation between OR and IOP in NPDR and PDR group (p=0,000). There was a significant relationship between patient age with OR and IOP (p<0,05). Conclusion: There is a significant correlation between ocular rigidity and IOP in people with type 2 DM.

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“…Andere Studien aus anderen geografischen Regionen unterstützen diese These [6][7][8]. Es finden sich jedoch auch Untersuchungen zu diesem Thema, die eine Assoziation zwischen Diabetes mellitus und erhöhtem IOD, aber keine Assoziation zu einem Glaukom und einem Optikusschaden nachweisen können [9][10][11]. Allerdings stößt man bei der Literaturrecherche auch auf eine Studie mit 6631 Patienten aus Schottland, bei der keine Assoziation zwischen Diabetes mellitus und PCOWG oder erhöhtem IOD nachgewiesen werden konnte [12] sowie einer Studie mit gleichem Ergebnis aus Rotterdam an 3837 Patienten [13].…”

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“…Teilweise wird der erhöhte IOD auf die bei Diabetikern erhöhte Hornhautdicke und veränderte Hornhautstruktur zurückgeführt [14]. So könnte es sich eventuell sogar um einen Messfehler und keinen real erhöhten IOD handeln [9]. Der Grund für den in einigen Studien festgestellen vermehrten Optikusschaden bei Diabetikern, teilweise auch ohne massiv erhöhten IOD, wird in dem durch den Diabetes mellitus verursachten mikrovaskulären Schaden gesehen.…”

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“…Der Grund für den in einigen Studien festgestellen vermehrten Optikusschaden bei Diabetikern, teilweise auch ohne massiv erhöhten IOD, wird in dem durch den Diabetes mellitus verursachten mikrovaskulären Schaden gesehen. Dieser wird durch eine veränderte Autoregulation in den Netzhautgefäßen und den Gefäßen des Optikus hervorgerufen [9]. Für eine vaskuläre Genese eines Glaukoms spricht ebenfalls eine Studie, die eine erhöhte 10-Jahres-Inzidenz eines Glaukoms bei Patienten mit verengten retinalen Arterien nachweisen konnte [15].…”

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Die Bedeutung des Diabetes mellitus für das Glaukom

Klemm

Gesser

2014

Klin Monatsbl Augenheilkd

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Although there are some hints for a correlation between diabetes and primary open angle glaucoma (POAG), it remains unclear in which way diabetes influences eye pressure (IOP) and glaucoma. Despite this, the main reason for neovascular glaucoma in diabetes is proven to be retinal ischaemia due to diabetic vessel damage. Primary open angle glaucoma is more frequent than neovascular glaucoma, but neovascular glaucoma is very aggressive and difficult to treat. The mainstay of the treatment is panretinal photo- or cryocoagulation. The next treatment options are cryodestructive procedures followed by filtering surgeries. In most cases a combination of treatments is necessary. In end-stage neovascular glaucoma sometimes enucleation is the only possible therapy when the IOP cannot be controlled or phthisis bulbi occurs.

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Intraocular pressure in Japanese diabetic patients

Cited by 11 publications

References 29 publications

Association between Urinary Albumin Excretion and Intraocular Pressure in Type 2 Diabetic Patients without Renal Impairment

Association between Urinary Albumin Excretion and Intraocular Pressure in Type 2 Diabetic Patients without Renal Impairment

Correlation Between Ocular Rigidity With Intraocular Pressure In Patient With Type 2 Diabetes Mellitus

Die Bedeutung des Diabetes mellitus für das Glaukom

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