Intraocular Pressure Fluctuation in Patients With Primary Open-angle Glaucoma Combined With High Myopia

Abstract

High-tension POAG patients with high myopia on only pharmacological glaucoma therapy have significantly greater IOP fluctuations after moderate and heavy exercise and do not have greater 24-hour IOP fluctuations at resting conditions.

Physical exercise and glaucoma: a review on the roles of physical exercise on intraocular pressure control, ocular blood flow regulation, neuroprotection and glaucoma‐related mental health

“…An additional and significant IOP reduction of 2.78 mmHg after 10 min of exercise on a cycle ergometer at an intensity of 20% maximum watt ( W max ), and 4.90 mmHg after 5 min of exercise at 60% W max , was also observed in patients with glaucoma on topical PGA instillation alone (Yang et al. ). Therefore, dynamic exercise induced an IOP reduction in patients with glaucoma, which was independent of the use of antiglaucoma agents.…”

“…Yang et al. () also suggested a more significant IOP reduction effect with more intensive exercise. Conte's group found that both high‐intensity‐interval training (HIT) and continuous moderate exercise (CME) were effective in IOP reduction in young healthy subjects.…”

“…Recently, Rufer et al (2014)) reported that 10 min of cycling on a cycle ergometer significantly decreased IOP by 2.3 mmHg, but the effect was not enhanced by prolonging the exercise period to 20 and 30 min, indicating that prolonging the duration did not intensify the amount of IOP reduction. Yang et al (2014) also suggested a more significant IOP reduction effect with more intensive exercise. Conte's group found that both high-intensityinterval training (HIT) and continuous moderate exercise (CME) were effective in IOP reduction in young healthy subjects.…”

“…Exercise‐induced IOP reduction was found to be markedly greater in POAG patients with high myopia (≥ −6D) compared with the nonhighly myopic and emmetropic groups (Yang et al. ). The potential mechanism remains unclear.…”

Emerging risk factors for glaucoma onset and progression

“…However, since IOP fluctuates over the course of a 24-h time period (Barkana et al, 2006;Konstas et al, 1997;Loewen et al, 2010;Song et al, 2014;Yang et al, 2014), continuous IOP monitoring would offer a more complete picture of true IOP. Nocturnal IOP measurements are of interest because IOP is higher in the habitual, supine position in many patients during nighttime hours (Liu and Weinreb, 2014).…”