Intraocular Pressure, Blood Pressure, and Retinal Blood Flow Autoregulation: A Mathematical Model to Clarify Their Relationship and Clinical Relevance

Guidoboni, Giovanna; Harris, Alon; Cassani, Simone; Arciero, Julia; Siesky, Brent; Amireskandari, Annahita; Tobe, Leslie; Egan, Patrick; Janulevičienė, Ingrida; Park, Joshua

doi:10.1167/iovs.13-13611

Cited by 118 publications

(127 citation statements)

References 96 publications

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“…This is in good agreement with findings made by Guidoboni et al, 46 who mathematically modeled IOP, BP, and the retinal auto regulation to assess the relationship of those factors. The main determinant of vascular resistance and, as such, of blood flow is, however, the diameter in the microcirculation.…”

Section: Discussionsupporting

confidence: 91%

Effect of Diffuse Luminance Flicker Light Stimulation on Total Retinal Blood Flow Assessed With Dual-Beam Bidirectional Doppler OCT

Aschinger

Schmetterer

Fondi

et al. 2017

Invest. Ophthalmol. Vis. Sci.

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METHODS. In six healthy subjects, TRBF was measured before and during stimulation with diffuse luminance flicker. Blood flow velocities in retinal vessels were measured via dual-beam bidirectional Doppler Fourier-domain optical coherence tomography (FD-OCT), retinal vessel diameters were assessed based on FD-OCT phase data. This allowed for the calculation of TRBF before and during visual stimulation. Additionally, a mathematical flow model for the retinal vasculature was adapted to study the implications of diameter variations on retinal perfusion. Measured and simulated perfusion was compared to draw conclusions on the diameter variations in different layers of the vascular tree.RESULTS. The measured mean baseline flow was 36.4 6 6.5 ll/min while the mean flow during flicker stimulation was 53.4% 6 8.3 ll/min. The individual increase in TRBF during flicker stimulation ranged between 34% and 66%. The average increase in TRBF over all measured subjects was 47.6% 6 12.6%.CONCLUSIONS. Dual-beam bidirectional Doppler FD-OCT allowed quantifying NC in the human retina in vivo and may be a promising method for monitoring alterations in NC caused by various pathologies. The comparison of the measured data with the results obtained in the simulated vasculature indicates that the vasodilation induced by NC is more pronounced in smaller vessels.

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Section: Discussionsupporting

confidence: 91%

Effect of Diffuse Luminance Flicker Light Stimulation on Total Retinal Blood Flow Assessed With Dual-Beam Bidirectional Doppler OCT

Aschinger

Schmetterer

Fondi

et al. 2017

Invest. Ophthalmol. Vis. Sci.

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“…The parameters are chosen to be comparable to those found in [16,24,25] and they are a realistic and representative set of parameters for retinal arterioles. The parameters used for the arteriole wall are ρ s = 1g/cm 3 , E = 0.05M P a, ν = 0.5, h κ = 5µm, h f = 20µm, k 0 = 0.4M P a, k 1 = 0, w = v = 0.5.…”

Section: Applicationmentioning

confidence: 99%

A simplified fluid–structure model for arterial flow. Application to retinal hemodynamics

Aletti

Gerbeau

Lombardi

2016

Computer Methods in Applied Mechanics and Engineering

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A simplified fluid-structure model for arterial flow.Application to retinal hemodynamics. AbstractWe propose a simplified fluid-structure interaction model for applications in hemodynamics. This work focuses on simulating the blood flow in arteries, but it could be useful in other situations where the wall displacement is small. As in other approaches presented in the literature, our simplified model mainly consists of a fluid problem on a fixed domain, with Robin-like boundary conditions and a first order transpiration. Its main novelty is the presence of fibers in the solid. As an interesting numerical side effect, the presence of fibers makes the model less sensitive than others to strong variations or inaccuracies in the curvatures of the wall. An application to retinal hemodynamics is investigated.

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“…Retinal vessel branches are connected to the optic nerve system via the lamina cribrosa structure (LCS), which is meshed with the central retina vein (CRV) and central retina artery (CRA), and so interact with the cardiovascular system. The intervals between heartbeats create fluctuations in the blood flow within the retina, attributed to continuous changes in the sympathetic-parasympathetic balance of the autonomous nervous system (ANS) [5]. We note from previous studies [6,7] that the quantification of such fluctuations is a vital factor in early detection of visual impairments resulting from cardiovascular disease, hypertension, diabetic autonomic dysfunction and some psychological disorders.…”

Section: Introductionmentioning

confidence: 99%

Assessing blood vessel perfusion and vital signs through retinal imaging photoplethysmography

Hassan

Jaidka

Dwyer

et al. 2018

Biomed. Opt. Express

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Abstract:One solution to the global challenge of increasing ocular disease is a cost-effective technique for rapid screening and assessment. Current ophthalmic imaging techniques, e.g. scanning and ocular blood flow systems, are expensive, complex to operate and utilize invasive contrast agents during assessment. The work presented here demonstrates a simple retinal imaging photoplethysmography (iPPG) system with the potential to provide screening, diagnosis, monitoring and assessment that is non-invasive, painless and radiationless. Time series of individual retinal blood vessel images, captured with an eye fundus camera, are processed using standard filtering, amplitude demodulation and principle component analysis (PCA) methods to determine the values of the heart rate (HR) and respiration rate (RR), which are in compliance with simultaneously obtained measurements using commercial pulse oximetry. It also seems possible that some information on the dynamic changes in oxygen saturation levels (SpO 2 ) in a retinal blood vessel may also be obtained. As a consequence, the retinal iPPG modality system demonstrates a potential avenue for rapid ophthalmic screening, and even early diagnosis, against ocular disease without the need for fluorescent or contrast agents.

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Intraocular Pressure, Blood Pressure, and Retinal Blood Flow Autoregulation: A Mathematical Model to Clarify Their Relationship and Clinical Relevance

Cited by 118 publications

References 96 publications

Effect of Diffuse Luminance Flicker Light Stimulation on Total Retinal Blood Flow Assessed With Dual-Beam Bidirectional Doppler OCT

Effect of Diffuse Luminance Flicker Light Stimulation on Total Retinal Blood Flow Assessed With Dual-Beam Bidirectional Doppler OCT

A simplified fluid–structure model for arterial flow. Application to retinal hemodynamics

Assessing blood vessel perfusion and vital signs through retinal imaging photoplethysmography

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