Intraocular Lenses, Axial Length, And Retinal Detachment

Clayman, Henry M.; Jaffe, Norman S.; Light, David S.; Jaffe, Mark S.; Cassady, Janet

doi:10.1016/s0002-9394(14)75629-6

Cited by 62 publications

(11 citation statements)

References 9 publications

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“…This value is also the highest in the world. It has been reported that myopia, especially high myopia, is a major risk factor of RRD [9,10,15]. These two factors contributed to the high incidence of RRD in our study.…”

Section: Discussionsupporting

confidence: 51%

“…Because the incidence of RRD is influenced by demographic characteristics [8], severe myopia [9,10], and history of cataract surgery [11,12], the incidence varies widely by region and age group. In Japan, a previous retrospective study reported that the incidence of RRD in Kumamoto Prefecture was 10.4 per 100,000 people (9.6 in males, 11.2 in females) [3].…”

Section: Introductionmentioning

confidence: 99%

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The Incidence of Rhegmatogenous Retinal Detachment in Kumamoto, Japan between 2009 and 2011

Haga¹,

Kawaji²,

Tsutsumi³

et al. 2017

J Clin Exp Ophthalmol

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Objective: The annual incidence of rhegmatogenous retinal detachment (RRD) in Kumamoto, Japan was previously evaluated in 1990. However, the incidence has not been evaluated during the last 20 years. The purpose of this study was to estimate the current incidence and epidemiologic characteristics of RRD in Kumamoto, Japan. Methods:The study was based on a retrospective chart review of hospital patients living in Kumamoto, Japan. All patients were treated for primary RRD by conventional surgery (pars plana vitrectomy and/or scleral buckling) at Kumamoto University Hospital or Ideta Eye Hospital between January 1, 2009, and December 31, 2011. Information on age, gender, refractive status, and history of cataract surgery was collected.Results: A total of 897 RRD patients were identified during the 3-year study period. The annual incidence of RRD was 16.5 (21.9 in males, 11.7 in females) per 100,000 people, with a peak incidence of 35.4 in the 50-59 years of age group. The incidence of RRD in males was 1.88 times (95% confidence interval, 1.56-2.29) higher than in females (P<0.0001). Prior cataract extraction was found in 14% of RRD eyes. Myopia (≤ −1 diopter [D]) was found in 54%, and high myopia (≤ −6 D) was found in 23%. The mean refraction status was −3.53 ± 3.94 D. The mean refractive status in patients younger than 50 years of age (−6.00 ± 3.33 D) was significantly higher than that in patients 50 years of age or older (−2.23 ± 3.61 D; P<0.001). The incidence of RRD in Kumamoto is expected to increase over the next 20 years in comparison to a previous study investigated in 1990. Conclusion:The annual incidence of RRD was dependent on age, gender, refraction status, and history of cataract surgery. Considering the growing elderly population, we expect that the incidence of RRD will continue to increase in Japan.

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Section: Discussionsupporting

confidence: 51%

Section: Introductionmentioning

confidence: 99%

The Incidence of Rhegmatogenous Retinal Detachment in Kumamoto, Japan between 2009 and 2011

Haga¹,

Kawaji²,

Tsutsumi³

et al. 2017

J Clin Exp Ophthalmol

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“…Hence it remains a consistent public health problem because of shortage of surgical facilities as well as the continuous replacement of old cases with new ones due to continued increase in longevity as well as the continued population growth. In addition, other vision-impairing surgical and post-surgical complications such as vitreous loss, macular edema and retinal detachment are known to occur in a significant number of people (~5%) (Stark et al 1984, Fine et al 1981, Clayman et al 1981, Smith et al 1987). Hence development of pharmacological means of cataract prevention is very desirable.…”

Section: Discussionmentioning

confidence: 99%

Inhibition of selenite‐induced cataract by caffeine

Varma

Hegde

Ковтун

2010

Acta Ophthalmologica

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ABSTRACT.Purpose: The objective of the investigation was to study possible inhibition of oxidative stress and cataract formation by caffeine in vivo. Methods: Oxidative stress and consequent cataract formation was induced by intraperitoneal administration of a single dose of sodium selenite (1.16 lmol) to Sprague-Dawley rat pups on day 9 postnatally. In experiments designed to inhibit such cataract formation, the pups were pretreated intraperitoneally with caffeine (5.15 lmol), starting 2 days prior to the administration of selenite and continuing such treatment till day 21, when the experiments were terminated. The extent of tissue damage caused by the selenite was assessed biochemically by measurements of the levels of GSH and ATP in the isolated lenses. Cataract formation and its prevention were monitored by examining the eye with pen light illumination and subsequent photography of the isolated lenses. Results: Injection of selenite led to a significant loss of lens clarity because of cataract formation. In the group treated with caffeine, the formation of cataract was significantly prevented. In the caffeine-untreated group, the levels of lens GSH and ATP were substantially lower than in the caffeine-treated group. The levels of GSH decreased from a value of $ 8.2 lmol to $ 2 lmol ⁄ g wet weight of the lens. The content of ATP decreased from $ 2.5 lmol to about $ 1 lmol. In the case of caffeine-treated group, these decreases were significantly prevented from taking place, the corresponding values of GSH and ATP being $ 5.8 and $ 1.6 lmol ⁄ g, respectively. Conclusion: Over all, the results suggest that caffeine can exert a significant preventive effect against cataract formation induced by agents generating reactive oxygen species such as sodium selenite.

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“…Inhibition of galactose-induced apoptosis by caffeine eye drops: The pictures represent the sections of the lens stained with DAPI (1–4) and F-UTP (5–8) Sections labeled 1 and 5 represent normal lenses. # 2 and 6 represent the lenses from normal rats treated with caffeine eye drops.…”

Section: Figurementioning

confidence: 99%

“…In addition, like with any surgery, there is always the possibility of inherent post-surgical complications which in this case can consist of a posterior capsular tear and consequent penetration of vitreous in the anterior chamber, cystoid macular edema, and often noted detachment of vitreous from the retina with photopsia and appearance of floaters (2, 3). The eye also has been reported now to be more prone to retinal detachment with significant loss of vision (4, 5). Removal of cataract has also been understood to hasten the appearance of macular changes associated with aging and diabetes.…”

Section: Introductionmentioning

confidence: 98%

Role of Ultraviolet Irradiation and Oxidative Stress in Cataract Formation—Medical Prevention by Nutritional Antioxidants and Metabolic Agonists

Varma¹,

Ковтун²,

Hegde³

2011

Eye &Amp; Contact Lens: Science &Amp; Clinical Practice

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Purpose Cataract is a significant cause of visual disability with relatively high incidence. It has been proposed that such high incidence is related to oxidative stress induced by continued intraocular penetration of light and consequent photochemical generation of reactive oxygen species such as superoxide and singlet oxygen and their derivatization to other oxidants such as hydrogen peroxide and hydroxyl radical. The latter two can also interact to generate singlet oxygen by Haber-Weis reaction. It has been proposed that in addition to the endogenous enzymatic antioxidant enzymes, the process can be inhibited by many nutritional and metabolic oxyradical scavengers such as ascorbate, vitamin E, pyruvate and xanthine alkaloids such as caffeine. Methods Initial verification of the hypothesis has been done primarily by rat and mouse lens organ culture studies under ambient as well as UV light irradiation and determining the effect of such irradiation on its physiology in terms of its efficiency of active membrane transport activity and the levels of certain metabolites such as GSH and ATP as well as in terms of apoptotic cell death. In vivo studies on the possible prevention of oxidative stress and cataract formation has been done by administering pyruvate and caffeine orally in drinking water as well as by their topical application using diabetic and galactosemic animal models. Results Photosensitized damage to lens has been found to be significantly prevented by ascorbate and pyruvate caused by exposure to visible as well as UVA. Caffeine has been found be effective against UVA as well as UVB. Oral or topical application of pyruvate has been found to inhibit the formation of cataracts induced by diabetes as well as galactosemia. Caffeine has also been found to inhibit cataract induced by sodium selenite as well as high levels of galactose. Studies with diabetes are in progress. Conclusion Various in vitro and in vivo studies summarized in the review strongly support the hypothesis that the light penetration into the eye is a significant contributory factor in the genesis of cataracts. The major effect is through photochemical generation of reactive oxygen species and consequent oxidative stress to the tissue. The results demonstrate that this can be averted by use of various antioxidants administered preferably by topical route. That they will be so effective is strongly suggested by the effectiveness of pyruvate and caffeine administered topically to diabetic and galactosemic animals.

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Intraocular Lenses, Axial Length, And Retinal Detachment

Cited by 62 publications

References 9 publications

The Incidence of Rhegmatogenous Retinal Detachment in Kumamoto, Japan between 2009 and 2011

The Incidence of Rhegmatogenous Retinal Detachment in Kumamoto, Japan between 2009 and 2011

Inhibition of selenite‐induced cataract by caffeine

Role of Ultraviolet Irradiation and Oxidative Stress in Cataract Formation—Medical Prevention by Nutritional Antioxidants and Metabolic Agonists

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