Intraocular Growth Factors and Cytokines in Patients With Dry and Neovascular Age-Related Macular Degeneration

Muether, Philipp S.; Neuhann, Irmingard M.; Buhl, Christoph; Hermann, Manuel M.; Kirchhof, Bernd; Fauser, Sascha

doi:10.1097/iae.0b013e318285cd9e

Cited by 38 publications

(38 citation statements)

References 21 publications

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“…In monkey eyes with laser-induced CNV, increased VEGF expression is detected in accumulating macrophages and migrating RPE cells in the CNV region [27]. Muether et al [11] reported that the intraocular VEGF level was elevated in intermediate dry AMD, but not in neovascular AMD. These findings suggest that VEGF contributes to CNV formation as the primary angiogenic signal, but VEGF levels do not reflect CNV activity [11].…”

Section: Discussionmentioning

confidence: 99%

“…Muether et al [11] reported that the intraocular VEGF level was elevated in intermediate dry AMD, but not in neovascular AMD. These findings suggest that VEGF contributes to CNV formation as the primary angiogenic signal, but VEGF levels do not reflect CNV activity [11].…”

Section: Discussionmentioning

confidence: 99%

“…It is clear that VEGF is the major stimulus for vascular endothelial cell proliferation during progression of AMD, and many studies have shown elevation of intraocular VEGF levels in patients with AMD [10,11]. However, macular edema sometimes persists and progresses despite intravitreal anti-VEGF therapy.…”

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confidence: 99%

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Aqueous Humor Levels of Cytokines in Patients with Age-Related Macular Degeneration

et al. 2018

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Purpose: To compare aqueous humor levels of various cytokines between patients with age-related macular degeneration (AMD) and cataract patients. Methods: Thirteen eyes with wet-type AMD (AMD group) and 14 eyes with cataract (cataract group) were studied. Aqueous humor levels of 11 factors (vascular endothelial growth factor receptors, growth factors, and inflammatory factors) were measured by the suspension array method. Results: Aqueous humor levels of vascular endothelial growth factor, soluble vascular endothelial growth factor receptor (sVEGFR)-1, sVEGFR-2, and inflammatory factors (monocyte chemotactic protein (MCP)-1, interleukin (IL)-6, and IL-8) were significantly higher in the AMD group than in the cataract group (all p < 0.05). In contrast, aqueous humor levels of placental growth factor (PGF), tumor necrosis factor-α, soluble intercellular adhesion molecule (sICAM)-1, IL-12 (p70), and IL-13 showed no significant difference between the two groups. There were significant correlations between sVEGFR-1 or sVEGFR-2 levels and some of the inflammatory molecules (PGF, sICAM-1, MCP-1, IL-6, and IL-8). Conclusions: These findings suggest that various cytokines/growth factors involved in inflammation and angiogenesis may be associated with the pathogenesis of AMD.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Aqueous Humor Levels of Cytokines in Patients with Age-Related Macular Degeneration

et al. 2018

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“…High levels of VEGF have been found in the aqueous and vitreous from subjects with DR (Endo et al 2000), neovascular age-related macular degeneration (AMD) (Jonas et al 2012;Miao et al 2012;Muether et al 2013), retinal vein occlusion (RVO) (Feng et al 2013) and retinopathy of prematurity (ROP) (Velez-Montoya et al 2010). It has also been shown that IOP level as well as success rates of surgical intervention in NVG subjects were associated with the intraocular level of VEGF ).…”

Section: Discussionmentioning

confidence: 99%

“…Growth factors (de Oliveira Dias et al 2011;Sasamoto et al 2012;Zhou et al 2013), inflammatory cytokines (Amadi-Obi et al 2012;Hoh Kam et al 2013;Whitcup et al 2013) and adhesion molecules (Grunin et al 2012;Juel et al 2012;Muether et al 2013) are important in angiogenesis and fibrosis formation. Their roles in inducing neovascular growth have been proved.…”

Section: Introductionmentioning

confidence: 99%

Expression of cytokines on the iris of patients with neovascular glaucoma

Hou

Miao

Tao

et al. 2014

Acta Ophthalmologica

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ABSTRACT.Purpose: To determine the expression levels of cytokines, including growth factors, inflammatory cytokines, and cell migration associated factors on the iris from subjects with neovascular glaucoma (NVG). Methods: After receiving formal consent from 12 subjects with NVG secondary to proliferative diabetic retinopathy and 12 subjects with primary open angle glaucoma (POAG), trabeculectomy was performed and iris specimens were collected during the surgery. Each subject with NVG received intravitreal injection of bevacizumab 1 week prior to the surgery. The mRNA level of vascular endothelial growth factor, basic fibroblastic growth factor, placentalinduced growth factor, interleukin-2, interleukin 6, tumour necrosis factor a, intercellular adhesion molecule 1 (ICAM-1) and integrin subunit a V were determined by real-time polymerase chain reaction. The mRNA levels were compared between the two groups. Results: The mRNA levels of all inflammatory cytokines and integrin subunit a V were significantly increased in the NVG group compared with POAG controls. However, the mRNA level of growth factors and ICAM-1 did not show any difference between the two groups. Conclusions: Inflammatory process maybe an important cause of iris neovascularization in subjects with NVG in addition to growth factors alone. Further studies should focus on the effect of growth factors in different phases in the pathogenesis of NVG.

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Müller glia as an important source of cytokines and inflammatory factors present in the gliotic retina during proliferative vitreoretinopathy

Eastlake¹,

Banerjee²,

Angbohang³

et al. 2015

Glia

111

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Retinal gliosis is characterized by biochemical and physiological changes that often lead to Müller glia proliferation and hypertrophy and is a feature of many neuro‐degenerative and inflammatory diseases such as proliferative vitreoretinopathy (PVR). Although Müller glia are known to release inflammatory factors and cytokines, it is not clear whether cytokine production by these cells mirrors the pattern of factors present in the gliotic retina. Lysates from normal cadaveric retina and gliotic retinal specimens from patients undergoing retinectomy for treatment of PVR, the Müller cell line MIO‐M1 and four human Müller glial cell preparations isolated from normal retina were examined for their expression of cytokines and inflammatory factors using semi‐quantitative dot blot antibody arrays and quantitative arrays. Comparative analysis of the expression of inflammatory factors showed that in comparison with normal retina, gliotic retina exhibited greater than twofold increase in 24/102 factors examined by semiquantitative arrays, and a significant increase in 19 out of 27 factors assessed by quantitative methods (P < 0.05 to P < 0.001). It was observed that with the exception of some chemotactic factors, the majority of cytokines and inflammatory factors were produced by Müller glia in vitro and included G‐CSF, MCP‐1, PDGF‐bb, RANTES, VEGF, and TGFβ2. These results showed that a large number of inflammatory factors expressed by Müller glia in vitro are upregulated in the gliotic retina, suggesting that targeting the production of inflammatory factors by Müller glia may constitute a valid approach to prevent neural damage during retinal gliosis and this merits further investigations. GLIA 2016;64:495–506

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Intraocular Growth Factors and Cytokines in Patients With Dry and Neovascular Age-Related Macular Degeneration

Cited by 38 publications

References 21 publications

Aqueous Humor Levels of Cytokines in Patients with Age-Related Macular Degeneration

Aqueous Humor Levels of Cytokines in Patients with Age-Related Macular Degeneration

Expression of cytokines on the iris of patients with neovascular glaucoma

Müller glia as an important source of cytokines and inflammatory factors present in the gliotic retina during proliferative vitreoretinopathy

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