Intraocular Choristoma

Abstract

Choristomas have been reported in the orbit, cornea, conjunctiva, uvea, retina, and optic nerve. Many reports have described the choristoma mainly in the epibulbar area, but little is known of the choristoma that occurs intraocularly. We reviewed the literature and summarized the reports that described the choristoma inside the eyes. Iris, ciliary body, choroid, and optic nerve head are the commonly affected tissues. In the anterior uveal tissue, an ectopic lacrimal gland is common and appears as a pinkish, nodular, fleshy mass. Its clinical course largely depends on the enlargement of the accompanying cyst. Osseous choristoma is mainly found in the choroid in young female patients. Although it is regarded as a benign tumor, it grows progressively and can decrease visual function. Treatment consists of close observation and possibly surgical intervention. Fortunately, most of the intraocular choristomas do not need aggressive treatment.

Optic Nerve: Developmental Anomalies and Common Tumors

“…Choristoma is an uncommon congenital tumor where normal-looking tissue (epithelial, glandular, cartilaginous, osseous, smooth muscle, and fat) is present in an area where it should not be normally present. Most ocular choristomas are periocular but can also be rarely found as an intraocular choristoma involving the iris, ciliary body, choroid, and optic nerve head [27]. The largest series on optic nerve choristomas in the English literature was published in 1972 including 26 cases of optic nerve colobomas in enucleated eyes, and all cases were diagnosed to have associated heterotopic adipose and/or smooth muscle tissue on pathological examination.…”

The use of SD-OCT in the differential diagnosis of dots, spots and other white retinal lesions

“…Osseous choristoma is defined as a congenital tumor consisting of ectopic osseous tissue in the choroid. 34 It is more prevalent in Caucasians and is reported more frequently in women than men. It is composed of bony trabeculae with numerous osteocytes and occasional osteoclasts.…”

“…It is composed of bony trabeculae with numerous osteocytes and occasional osteoclasts. 34 Fundoscopically, osseous choristoma appears yellowish-white to sometimes reddish in color ( Figure 22). 34 It can be elevated ranging from 0.5 to 2.00 mm elevation.…”

“…34 Fundoscopically, osseous choristoma appears yellowish-white to sometimes reddish in color ( Figure 22). 34 It can be elevated ranging from 0.5 to 2.00 mm elevation. 35 The size ranges from 1.5 × 2 DD to 9 × 15 DD.…”

“…35 It has been reported that RPE can show areas of depigmentation and areas of RPE clumping; whereas, retina overlying the tumor can show focal degeneration of outer segments. 34 Given the relatively evaluations, guidelines, expert opinion and commentary, case reports and extended reports are welcome. The manuscript management system is completely online and includes a very quick and fair peer-review system, which is all easy to use.…”