Intraobserver reproducibility of parameters of standard and 2D speckle tracking echocardiography, dynamics of global longitudinal strain I in patients with acute primary anterior STEMI

Kercheva, M. A.; Ryabova, Tamara; Ryabov, V. V.; Карпов, Р. С.

doi:10.1063/1.4936012

Cited by 4 publications

(5 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…All echocardiography images were analyzed offline by a single independent ultrasound diagnostic specialist, who was without any information about patient history. 20–22 All data were obtained on an ultrasound machine Vivid E9 (GE Healthcare) and saved on CD-ROM drives. Then, these images were transferred and analyzed with the software GE EchoPac.…”

Section: Methodsmentioning

confidence: 99%

“…Standard transthoracic echocardiography was performed at days 3 (T2), 7 (T3), and 14 (T4) and 6 months (T5) after STEMI onset (Vivid E9; GE Healthcare). 20,21 Serum was sampled at the same times and also at day 1 (T1) after STEMI onset. A scientific collaborator from the Department of Laboratory Diagnostics determined serum levels of sST2, NT-proBNP, and hCRP by an immunoenzymatic assay method.…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Serum Soluble ST2 and Adverse Left Ventricular Remodeling in Patients With ST-Segment Elevation Myocardial Infarction

Kercheva

Ryabova

Гусакова

et al. 2019

Clin Med Insights Cardiol

View full text Add to dashboard Cite

Objective: To assess the dynamics of serum levels of soluble isoform of suppression of tumorigenicity 2 (sST2) and N-terminal pro-brain natriuretic peptide (NT-proBNP) and their correlations with the development of adverse left ventricular remodeling (LVR) through 6 months in patients with primary myocardial infarction with ST-segment elevation (STEMI). Methods: Subjects were 31 patients with STEMI (median age: 58 years), who underwent percutaneous coronary intervention (PCI) during the first 24 hours of the onset of myocardial infarction (MI). Blood samples and parameters of echocardiography were assessed at days 1, 3, 7, and 14 and 6 months after STEMI. Results: Serum levels of sST2 and NT-proBNP decreased during the 6-month period. Levels of sST2 decreased by 48% from admission to day 7, and levels of NT-proBNP decreased by 40% from day 7 to 6 months after STEMI. Serum levels of sST2 at day 1 ( r = 0.5, P < .05) and day 3 ( r = 0.4, P < .05) were associated with adverse LVR by 6 months after STEMI. Logistic regression analysis showed that a high concentration of sST2 at day 7 increased the risk of adverse LVR (95% confidence interval [CI], 0.5-0.9; areas under curve [AUC] = 0.8; P = .002), with 92% sensitivity and 70% specificity. A multivariate analysis model revealed that adverse LVR was associated with the level of sST2 ( P = .003) and with complete revascularization ( P = .01) at the admission. Conclusions: The dynamics of serum levels of sST2 and NT-proBNP were different. The level of sST2 normalized by the 7th day; NT-proBNP decreased only by the end of the 6-month period after MI. Increased serum levels of sST2 by the 7th day of MI were associated with the development of adverse LVR by the end of the 6-month period.

show abstract

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Serum Soluble ST2 and Adverse Left Ventricular Remodeling in Patients With ST-Segment Elevation Myocardial Infarction

Kercheva

Ryabova

Гусакова

et al. 2019

Clin Med Insights Cardiol

View full text Add to dashboard Cite

show abstract

“…Кроме оценки деформации миокарда, технология предлагает инструменты для изучения сложной биомеханики сердца и оценки вос-становления нарушенных в результате ИМ функций сердца. Ранее нами и коллегами показана высокая вну-три-и межоператорская воспроизводимость показате-лей 2D speckle tracking эхокардиографии, в том числе и GLS [12,13]. Установлено, что деформация у обследо-ванных больных улучшается уже к 7-м суткам, и эта динамика сохраняется к моменту выписки больного из стационара.…”

Section: Discussionunclassified

Eart Hemodynamics in Early Period of Acute St Elevation Anterior Myocardial Infarction by 2d Speckle Tracking Echocardiography

Kercheva¹,

Рябова²,

Рябов³

et al. 2016

Russ J Cardiol

View full text Add to dashboard Cite

Цель. Оценить изменение биомеханики сердца в ранние сроки у пациентов с острым первичным передним инфарктом миокарда (ИМ) с подъемом сег-мента ST по данным стандартной и 2D speckle tracking эхокардиографии. Материал и методы. В исследование включено 35 пациентов (средний воз-раст -58,46±10,2) с острым Q-ИМ, поступивших в первые 24 часа от начала заболевания. Эхокардиографию, включая 2D speckle tracking режим, прово-дили на 3-и (T1), 7-е (T2) и 14-е сутки (T3) острого ИМ ("Vivid E9"). Пациентов разделили на 2 группы, с наличием неблагоприятного ремоделирования левого желудочка (ЛЖР+) к 14-м суткам и без (ЛЖР-). Результаты. Экстренная реперфузионная терапия -у всех пациентов (72% -в первые 6 часов). Значимой динамики показателей стандартной эхо-кардиографии -конечного диастолического (КДО) и систолического объемов (КСО), фракции выброса (ФВ), индекса нарушения локальной сократимости (ИНЛС) ЛЖ, не выявлено. Отмечено улучшение деформации -2D global longitudinal strain (GLS) к Т2 (p=0,048). Апикальная и базальная ротация -без динамики в течение всего периода наблюдения. Однако, количество пациен-тов с нормальным и сниженным значением базальной ротации и её систоличе-ской скорости, а также нормальным и повышенным значением апикальной ротации и её систолической скорости к Т3 выросло (p<0,05). Выявлено увели-чение систолической скорости твиста к Т3. В группе ЛЖР+ выявлено улучше-ние ИНЛС и 2D GLS к Т3. Систолическая скорость апикальной ротации и твиста повысились к Т3, однако все скоростные показатели -значительно меньше, чем в группе ЛЖР-. По клинико-анамнестическим данным группы различались по времени реперфузии: 5,48±3,58 против 3,89±2,25 ч (р<0,05). Заключение. Изменения биомеханики сердца по данным 2D speckle tracking эхокардиографии у пациентов с применением современной и своевременной фармакоинвазивной стратегии в ранний постинфарктный период отображали восстановление функции сердца, стандартные показатели (КДО, КСО, ФВ ЛЖ) динамики не показали. Улучшение 2D GLS происходило уже к точке Т2. Среди показателей, отражающих ротационные характеристики ЛЖ, повышалась систолическая скорость апикальной ротации к Т3. Базальная и апикальная ротация динамику не показали. Увеличилось количество пациентов с нор-мальной и повышенной апикальной ротацией, а также со сниженной и нор-мальной базальной ротацией к Т3. В группе ЛЖР+ реперфузия миокарда достигалась значимо позже, отмечено улучшение 2D GLS и ИНЛС ЛЖ к Т3, а также скоростных показателей апикальной ротации, твиста. Aim. To assess the changes in biomechanics of the heart at early stages post-acute ST-elevation myocardial infarction (MI) by 2D speckle tracking echocardiography. Material and methods. Totally, 35 patients included (mean age -58,46±10,2 year old) with acute Q-MI admitted within 24 hours from the disease onset. Echocardiography, including 2D speckle tracking regimen was done at the 3rd (T1), 7th (T2) and 14th (T3) day post-MI (Vivid E9 device). Patients were selected to two groups: with an adverse remodeling of the left ventricle (LVR+) by 14th day and without ...

show abstract

“…STEMI was diagnosed based on the third universal definition of MI [ 2 ]. Echocardiography was performed in all patients at Days 3 (T2), 7 (T3) and 14 (T4) and six months (T5) after STEMI onset (Vivid E9, GE Healthcare, Boston, MA, USA) [ 4 , 11 , 12 ]. The obtained images were stored on CD-ROM drives and then analyzed using GE EchoPAC software (GE, Healthcare, EchoPac 113, Boston, MA, USA).…”

Section: Methodsmentioning

confidence: 99%

Serum Levels of Bone Morphogenetic Proteins 2 and 4 in Patients with Acute Myocardial Infarction

Kercheva

Гусакова

Ryabova

et al. 2020

Cells

View full text Add to dashboard Cite

Background: Bone morphogenetic proteins-2 and -4 (BMPs) have been implicated in left ventricular remodeling (LVR) processes such as an inflammation and fibrogenesis. We hypothesized that this knowledge could be translated into clinics. Methods: We studied the dynamics of serum levels of BMPs, its correlation with markers of LVR and with parameters of echocardiography in patients (n = 31) during the six-month follow-up period after myocardial infarction (MI). Results: Elevated serum levels of BMPs decreased by the six-month follow-up period. BMP-2 decreased from the first day after MI, and BMP-4 decreased from the Day 14. The elevated level of BMP-2 at Day 1 was associated with a lower level of troponin I, reperfusion time and better left ventricular ejection fraction (LV EF) at the six-month follow-up. Elevated serum level of BMP-4 at Day 1 was associated with a lower level of a soluble isoform of suppression of tumorigenicity 2 (sST2), age and reperfusion time. An elevated level of BMP-2 at the six-month follow-up was associated with higher levels of BMP-4, high-sensitivity C-reactive protein (hCRP) and sST2. High serum level of BMP-2 correlated with high levels of hCRP and matrix metalloproteinase (MMP)-9 on Day 7. High serum level of BMP-4 correlated with low levels of hCRP, MMP-9 at Day 3, sST2 at Day 1 and with decreased LV EF on Day 7. The findings of multivariate analysis support the involvement of BMP-2 in the development of post-infarction LVR. Conclusions: Our research translates experimental data about the BMPs in the development of adverse LVR into the clinic. Elevated serum levels of BMPs decreased by the end of the six-month period after MI. BMP-2 decreased from the first day and BMP-4 decreased from Day 14. BMP-2 and BMP-4 were associated with the development of LVR. Their correlations with markers of inflammation, degradation of the extracellular matrix, hemodynamic stress and markers of myocardial damage further support our hypothesis. Diagnostic and predictive values of these BMPs at the development of post-infarction LVR in vivo should be investigated further.

show abstract

Intraobserver reproducibility of parameters of standard and 2D speckle tracking echocardiography, dynamics of global longitudinal strain I in patients with acute primary anterior STEMI

Cited by 4 publications

References 13 publications

Serum Soluble ST2 and Adverse Left Ventricular Remodeling in Patients With ST-Segment Elevation Myocardial Infarction

Serum Soluble ST2 and Adverse Left Ventricular Remodeling in Patients With ST-Segment Elevation Myocardial Infarction

Eart Hemodynamics in Early Period of Acute St Elevation Anterior Myocardial Infarction by 2d Speckle Tracking Echocardiography

Serum Levels of Bone Morphogenetic Proteins 2 and 4 in Patients with Acute Myocardial Infarction

Contact Info

Product

Resources

About