Intranuclear inclusions in pericytes of the hypothalamus of the rat

Lafarga, Miguel; Hervás, José-Pablo

doi:10.1007/bf00209043

Cited by 7 publications

(2 citation statements)

References 25 publications

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“…Several structures different from but related to the chromatin and to the nucleolus have been documented in the nucleus of animal cells. Some of them appear in a great variety of cell types and can be considered normal nuclear constituents, namely, the interchromatin and perichromatin granules (Fakan and Bernhard, 1973;Wassef, 1979;Smetana et al, 1979), whereas others are found only in certain cell nuclei, such as the "nuclear bodies" (Dupuy-Coin et al, 1972;Schulze, 1979); the "intranuclear rodlets," which are frequent in neurons (Feldman and Peters, 1972;Lafarga and Palacios, 1979;Seite et al, 1979); and the "coiled bodies" described in hepatic and pancreatic cells (Monneron and Bernhard, 1969) and trophoblast cells (Tor6 and Rohlich, 1966). In nerve cells, a limited number of ultrastruct u r d studies on nuclei have been concerned with the occurrence of small, electron-dense aggregates of coiled threadlike masses, which have been reported under a variety of names: "accessory bodies of Cajal" (Hardin et al, 1969), "spotted bodies" 197 l), and "paranucleolar" and "coiled bodies" (Le Beux, 1971).…”

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confidence: 99%

Coiled bodies in supraoptic nuclei of the rat hypothalamus during the postnatal period

Hervás

Villegas²,

Crespo³

et al. 1980

Am. J. Anat.

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In electron microscopic studies of the supraoptic nuclei of the rat hypothalamus, structures identified as "coiled bodies" were found in magnocellular neurons. Although they could be seen elsewhere in mature neurosecretory cells, coiled bodies were commonly encountered in developing neurons during the postnatal period in both sexes. They appeared as distinctive nuclear inclusions consisting of round-to-oval networks of short electron-dense strands embedded in a less dense, fibrillar matrix, and lacking a limiting membrane. In fine structure and stain-affinity, they bore a resemblance to the fibrillar component of the nucleolus. Coiled bodies were located either in close association with the nucleolus or free within the nucleoplasm, showing no specific relationships with the perinucleolar chromatin or with the nuclear envelope. Their origin and functional meaning is discussed in the light of recent ultrastructural and biochemical data on cellular differentiation and nucleolar behavior.

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confidence: 99%

Coiled bodies in supraoptic nuclei of the rat hypothalamus during the postnatal period

Hervás

Villegas²,

Crespo³

et al. 1980

Am. J. Anat.

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“…This dual path could explain its both pro-cancer and anti-tumor effects. dicer enzyme —Dicer enzyme is a microRNA that has been associated with pregnancy-induced hypertension [ 68 ] as well as the brain renin–angiotensin II-induced hypertension and cardiac hypertrophy [ 72 ]. More recently, one isoform of Dicer, named antiviral Dicer (aviD), was found to protect tissue stem cells from RNA viruses—including Zika virus and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)—by dicing viral double-stranded RNA to orchestrate antiviral RNAi [ 73 ].…”

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confidence: 99%

Literature-Based Discovery to Elucidate the Biological Links between Resistant Hypertension and COVID-19

Kartchner,

McCoy,

Dubey

et al. 2023

Biology

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Multiple studies have reported new or exacerbated persistent or resistant hypertension in patients previously infected with COVID-19. We used literature-based discovery to identify and prioritize multi-scalar explanatory biology that relates resistant hypertension to COVID-19. Cross-domain text mining of 33+ million PubMed articles within a comprehensive knowledge graph was performed using SemNet 2.0. Unsupervised rank aggregation determined which concepts were most relevant utilizing the normalized HeteSim score. A series of simulations identified concepts directly related to COVID-19 and resistant hypertension or connected via one of three renin–angiotensin–aldosterone system hub nodes (mineralocorticoid receptor, epithelial sodium channel, angiotensin I receptor). The top-ranking concepts relating COVID-19 to resistant hypertension included: cGMP-dependent protein kinase II, MAP3K1, haspin, ral guanine nucleotide exchange factor, N-(3-Oxododecanoyl)-L-homoserine lactone, aspartic endopeptidases, metabotropic glutamate receptors, choline-phosphate cytidylyltransferase, protein tyrosine phosphatase, tat genes, MAP3K10, uridine kinase, dicer enzyme, CMD1B, USP17L2, FLNA, exportin 5, somatotropin releasing hormone, beta-melanocyte stimulating hormone, pegylated leptin, beta-lipoprotein, corticotropin, growth hormone-releasing peptide 2, pro-opiomelanocortin, alpha-melanocyte stimulating hormone, prolactin, thyroid hormone, poly-beta-hydroxybutyrate depolymerase, CR 1392, BCR-ABL fusion gene, high density lipoprotein sphingomyelin, pregnancy-associated murine protein 1, recQ4 helicase, immunoglobulin heavy chain variable domain, aglycotransferrin, host cell factor C1, ATP6V0D1, imipramine demethylase, TRIM40, H3C2 gene, COL1A1+COL1A2 gene, QARS gene, VPS54, TPM2, MPST, EXOSC2, ribosomal protein S10, TAP-144, gonadotropins, human gonadotropin releasing hormone 1, beta-lipotropin, octreotide, salmon calcitonin, des-n-octanoyl ghrelin, liraglutide, gastrins. Concepts were mapped to six physiological themes: altered endocrine function, 23.1%; inflammation or cytokine storm, 21.3%; lipid metabolism and atherosclerosis, 17.6%; sympathetic input to blood pressure regulation, 16.7%; altered entry of COVID-19 virus, 14.8%; and unknown, 6.5%.

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Capillary pericytes: Perspectives and future trends

Tilton

1991

J. Elec. Microsc. Tech.

100

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A complete understanding of the microcirculation requires full knowledge of the structure and function of each of the constituent cells, including pericytes. Vascular endothelium and smooth muscle cells have been investigated intensively during the last two decades, but much less is known about the metabolism and function of capillary pericytes. However, the development of new electron microscopy techniques and the application of new cell culture and molecular biology techniques should allow for the rapid elucidation of the cellular biochemistry and the microvascular function and pathology of this ubiquitous capillary cell.

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Intranuclear inclusions in pericytes of the hypothalamus of the rat

Cited by 7 publications

References 25 publications

Coiled bodies in supraoptic nuclei of the rat hypothalamus during the postnatal period

Coiled bodies in supraoptic nuclei of the rat hypothalamus during the postnatal period

Literature-Based Discovery to Elucidate the Biological Links between Resistant Hypertension and COVID-19

Capillary pericytes: Perspectives and future trends

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