Intranuclear and intranucleolar tubular structures in novikoff hepatoma cells

Babaï, Féridoun; Tremblay, Guy; Dumont, André

doi:10.1016/s0022-5320(69)90010-0

Cited by 20 publications

(7 citation statements)

References 7 publications

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“…The straight or slightly bent intranuclear tubules presented by us, are structurally in accord with those described by Babai et al (1969) in Novikoff hepatoma cells and by Ferrans et al (1975) as 'tubules of the first type' in human cardiac muscle cells. Yet, a significant observation of the present study, not reported in earlier works, is the presence of pronounced tubular bendings at the points of termination of the straight running segments.…”

Section: Discussionsupporting

confidence: 89%

“…In a recent publication, Ferrans et al (1975) showed the presence of abnormal membrane inclusions in nuclei of human myocardial cells. Similar findings have been reported in cell nuclei of a variety of cells (Bernhard and Granboulan, 1963;Clyman, 1963;Terzakis, 1965;Babai et al, 1969). In an ultrastructural study of the hypertrophied human myocardium (Jensen et al, 1976;Saetersdal et al, 1976) we have observed intranuclear membrane structures similar in general appearance to those reported by Ferrans et al (1975).…”

supporting

confidence: 89%

“…The functional significance of these nuclear aberrances is still unknown. Previous studies (Babai et al, 1969;Ferrans et al, 1975) have reported that the pseudoinclusions contain cytoplasmic organelles normally present in the perinuclear area. Such cytoplasmic organelles were seen by us only in the larger cytoplasmic invaginations of the nuclear envelope.…”

Section: Discussionmentioning

confidence: 86%

“…Such structures were originally described by Bernhard and Granboulan (1963) in cancer cell nuclei and named 'pseudoinclusions'. They have since been found in cell nuclei of a variety of cells (Babai et al, 1969;Sobel et al, 1969;Ferrans et al, 1975).…”

Section: Discussionmentioning

confidence: 97%

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Ultrastructure of abnormal membrane inclusions in nuclei of human myocardial cells.

Engedal¹,

Jensen²,

Sætersdal³

1977

Heart

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Section: Discussionsupporting

confidence: 89%

supporting

confidence: 89%

Section: Discussionmentioning

confidence: 86%

Section: Discussionmentioning

confidence: 97%

See 2 more Smart Citations

Ultrastructure of abnormal membrane inclusions in nuclei of human myocardial cells.

Engedal¹,

Jensen²,

Sætersdal³

1977

Heart

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“…This may appear surprising, however, formation of cubic membranes within nuclei could be realized by invaginations of a proliferating inner nuclear membrane. Intranuclear cubic or tubular membrane organizations usually develop in fast replicating neoplastic (tumor) cells (Babai et al, 1969;Karasaki, 1970) or non-neoplastic cells such as oocytes (Kessel and Beams, 1968;Miller, 1966). Their presence might play a role in mitotic activity or in facilitating nuclear-cytoplasmic communication.…”

Section: Inner Nuclear Membranementioning

confidence: 99%

Chapter 6 Cubic Membranes

Almsherqi

Landh

Kohlwein

et al. 2009

International Review of Cell and Molecular Biology

128

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Biological membranes are among the most fascinating assemblies of biomolecules: a bilayer less than 10 nm thick, composed of rather small lipid molecules that are held together simply by noncovalent forces, defines the cell and discriminates between "inside" and "outside", survival, and death. Intracellular compartmentalization-governed by biomembranes as well-is a characteristic feature of eukaryotic cells, which allows them to fulfill multiple and highly specialized anabolic and catabolic functions in strictly controlled environments. Although cellular membranes are generally visualized as flat sheets or closely folded isolated objects, multiple observations also demonstrate that membranes may fold into "unusual", highly organized structures with 2D or 3D periodicity. The obvious correlation of highly convoluted membrane organizations with pathological cellular states, for example, as a consequence of viral infection, deserves close consideration. However, knowledge about formation and function of these highly organized 3D periodic membrane structures is scarce, primarily due to the lack of appropriate techniques for their analysis in vivo. Currently, the only direct way to characterize cellular membrane architecture is by transmission electron microscopy (TEM). However, deciphering the spatial architecture solely based on two-dimensionally projected TEM images is a challenging task and prone to artifacts. In this review, we will provide an update on the current progress in identifying and analyzing 3D membrane architectures in biological systems, with a special focus on membranes with cubic symmetry, and their potential role in physiological and pathophysiological conditions. Proteomics and lipidomics approaches in defined experimental cell systems may prove instrumental to understand formation and function of 3D membrane morphologies.

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Intranuclear tubular structures observed in the cells of an alveolar cell carcinoma of the lung

Torikata

Ishiwata

1977

Cancer

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Intranuclear tubular structures observed in the cells of an alveolar cell carci-noma of the lung are described. The structures were composed of mem-braneous tubules, measured about 60 nm in diameter, and had an electron-dense central core. These unusual structures were seen in the nuclei of neo-plastic cells (Type I1 pneumocytes). The nature of the tubular structures remains unsolved, but morphologic characteristics and associated granulomatous reaction in the stroma imply the possibility of an unknown virus-like infection.

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Intranuclear and intranucleolar tubular structures in novikoff hepatoma cells

Cited by 20 publications

References 7 publications

Ultrastructure of abnormal membrane inclusions in nuclei of human myocardial cells.

Ultrastructure of abnormal membrane inclusions in nuclei of human myocardial cells.

Chapter 6 Cubic Membranes

Intranuclear tubular structures observed in the cells of an alveolar cell carcinoma of the lung

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