Ultrastructure of abnormal membrane inclusions in nuclei of human myocardial cells.

Engedal, Hogne; Jensen, H A; Sætersdal, Thorvald

doi:10.1136/hrt.39.2.145

Cited by 13 publications

(3 citation statements)

References 10 publications

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“…Repeated bouts of endogenous catecholamine release associated with captivity and routine manipulation during toxicology studies is believed to cause focal or multifocal damage to the myocardium (Keenan and Vidal 2006; Lowenstine 2003). Intranuclear (pseudo) inclusion bodies in hypertrophic cardiac myofibers resulting from intranuclear invagination of cytoplasmic organelles, including mitochondria, have been reported in man (Engedal et al 1977).…”

Section: Discussionmentioning

confidence: 99%

“…4, 2010 SPONTANEOUS FINDINGS IN CYNOMOLGUS MONKEYScause focal or multifocal damage to the myocardium (Keenan and Vidal 2006;Lowenstine 2003). Intranuclear (pseudo) inclusion bodies in hypertrophic cardiac myofibers resulting from intranuclear invagination of cytoplasmic organelles, including mitochondria, have been reported in man (Engedal et al 1977). One of the most common observations in general was the frequency and extent of lymphoid hyperplasia in various organs in control study animals.…”

Section: Discussionmentioning

confidence: 99%

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Incidences and Range of Spontaneous Findings in Control Cynomolgus Monkeys (Macaca fascicularis) Used in Toxicity Studies

et al. 2010

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The authors performed a retrospective study to determine the incidences and range of spontaneous pathology findings in control cynomolgus monkeys. Data were collected from 570 monkeys (285 animals per sex), aged twelve to thirty-six months, from sixty regulatory studies evaluated at our laboratory between 2003 and 2009. The most common finding overall was lymphoplasmacytic infiltrates observed in the following incidence: liver (60.7%), kidneys (28.8%), heart (25.8%), salivary glands (21.2%), and stomach (12.1%). Inflammation also commonly occurred in the heart, kidneys, lungs, and stomach. The most common degenerative changes were localized fatty change in the liver, myocardial degeneration, and mineralization and pigment deposits in various tissues. Parathyroid, thyroid, and pituitary cysts; ectopic thymus in the parathyroid or thyroid gland; accessory spleen within the pancreas; and adrenohepatic fusion were among the most common congenital findings. Some incidental findings bearing similarities to drug-induced lesions were also encountered in various organs. It is hoped that the results presented here and elsewhere could form the groundwork for the creation of a reliable database of incidental pathology findings in laboratory nonhuman primates.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Incidences and Range of Spontaneous Findings in Control Cynomolgus Monkeys (Macaca fascicularis) Used in Toxicity Studies

et al. 2010

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“…They figured out that these inclusion bodies were the first sign in cellular degeneration and resulted in pyknosis. Engedal et al (1977) stated that their formation arose by the unification of membranes in the nucleoplasm. Furthermore, the course of cell death was assigned by the indentation of the nuclear envelope (Trump et al, 1997;Pazir et al, 2011).…”

Section: Discussionmentioning

confidence: 99%

Midgut cells alteration in gamma-irradiated beetles (Blaps polycresta, Coleoptera: Tenebrionidae)

Kheirallah

El-Samad

2020

Braz. J. Biol.

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Abstract This study was conducted to examine the effect of gamma radiation on biological specimens. Thus, our concept is to clarify that exposure to accumulated dose of 0.2 Gy gamma rays (0.66 rad/Sec. dose rate) from Cs137 source induces cellular perturbations in the midgut epithelium of the F1 progeny of Blaps polycresta, therefore affecting nutrition and growth. Beetles were reared in laboratory conditions and the newly emerged adults were irradiated with the aforementioned dose. Histological and ultrastructure anomalies of midgut cells (digestive and regenerative cells) were observed by 72 h after radiation exposure to ensure that the cells will not return to control state. Retardation in the development of the F1 progeny was also noticed and beetles died through two weeks. In the light of these observations, biological tissue act as an indicator to the continuous exposure to environmental radiation.

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Ultrastructural Pathology of the Nucleus

Kamel¹,

Kirk²,

Toner³

1990

Current Topics in Pathology

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Ultrastructure of abnormal membrane inclusions in nuclei of human myocardial cells.

Cited by 13 publications

References 10 publications

Incidences and Range of Spontaneous Findings in Control Cynomolgus Monkeys (Macaca fascicularis) Used in Toxicity Studies

Incidences and Range of Spontaneous Findings in Control Cynomolgus Monkeys (Macaca fascicularis) Used in Toxicity Studies

Midgut cells alteration in gamma-irradiated beetles (Blaps polycresta, Coleoptera: Tenebrionidae)

Ultrastructural Pathology of the Nucleus

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