Intranodal Schwannoma Mimicking a Gastrointestinal Stromal Tumor of the Stomach: A Case Report

Nam, Kyung Bum; Namkung, Sook; Kim, Heung Cheol; Kim, Hae Sung; Ryu, Byoung Y.; Choi, Young Hee

doi:10.3348/jksr.2011.65.4.395

Cited by 6 publications

(6 citation statements)

References 10 publications

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“…Intranodal schwannomas are rare and only a few reports have been described in the English literature (<15 cases). In most of these reports, schwannomas were located in retroperitoneal or pericolic lymph nodes 3 , 5 , 7 – 9 , thoracic region, 10 , 11 and even adjacent to the adrenal gland, 6 , 12 with only one case report in the cervical region—Jennifer et al 4 Therefore, our case is the second cervical intranodal schwannoma described in literature and, to the best of our knowledge, the first to be reported in our country.…”

Section: Discussionmentioning

confidence: 64%

“…1–12 As for malignant lesions, it must be considered as a malignant peripheral nerve sheath tumor or metastatic lesions such as spindle cell carcinoma, melanoma, or spindle-cell sarcoma. 1–12…”

Section: Discussionmentioning

confidence: 99%

“…2 , 4 – 6 Mitosis are rare or absent. Ancilary studies can be helpful confirming this diagnosis, with tumor cells being positive for S100 protein 2 , 4 – 7 (family of low-molecular weight proteins present in cells derived from the neural crest) and vimentin (protein found in the cytoskeleton of mesenchymal cells), and showing no evidence of smooth muscle or epithelial differentiation.…”

Section: Discussionmentioning

confidence: 99%

“…The differential diagnosis for schwannomas arising in a lymph node include, for benign lesions: neurofibroma (nonencapsulated lesions-unlike schwannoma), leiomyoma, palisaded myofibroblastoma and inflammatory pseudotumor of lymph node. 1 – 12 As for malignant lesions, it must be considered as a malignant peripheral nerve sheath tumor or metastatic lesions such as spindle cell carcinoma, melanoma, or spindle-cell sarcoma. 1 – 12 …”

Section: Discussionmentioning

confidence: 99%

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Cervical Lymph Node Schwannoma—An Unexpected Diagnosis

Silvestre

Tavares

Lopéz‐Presa

et al. 2019

Clin Med�Insights�Pathol

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Introduction:Schwannomas—Schwann cells–originating tumors—may develop in many locations. However, primary schwannomas arising within lymph nodes are extremely rare, with only a few cases described to this date in the English literature. For the intranodal location, most of the cases are described in the abdominal cavity. In these cases, clinicians may consider and check for familial disorders, such as neurofibromatosis type 2 (NF2) and schwannomatosis also called neurofibromatosis type 3. Schwannomas are benign neoplasms. Histologically, differential diagnosis for spindle-cell lesions in lymph nodes is important and must be done carefully, mainly because they may be attributable to metastatic disease. We report a case of a primary schwannoma arising in a cervical lymph node.Background:Primary schwannomas arising within lymph nodes are extremely rare, with only a few cases reported. Since they are benign neoplasms, the differential diagnosis with other intranodal spindle cell lesions, mostly malignant, is important.Methods:An asymptomatic 69-year-old woman, previously submitted to left hemithyroidectomy for a benign folicular nodule, underwent thyroidectomy totalization following the identification of a large thyroid nodule in routine evaluation.Results:Gross and microscopic examination and ancillary studies were consistent with the diagnosis of intranodal schwannoma. The patient had acquired bilateral hypoacusia. Therefore, type 2 neurofibromatosis was considered and vestibular schwannomas ruled out.Conclusion:Herein, we present the second case of a primary schwannoma in a cervical lymph node reported so far. The relevance of the differential diagnosis is highlighted.

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Section: Discussionmentioning

confidence: 64%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Cervical Lymph Node Schwannoma—An Unexpected Diagnosis

Silvestre

Tavares

Lopéz‐Presa

et al. 2019

Clin Med�Insights�Pathol

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“…Regarding IHC features, these tumors present S100 protein, which are low-molecular weight proteins of cells originating from the neural crest [10,15]. Therefore, in our case, the strong positive expression of S100 protein on IHC analysis, along with the absence of SMA or desmin were useful in making the main differential diagnosis with intranodal palisaded myofibroblastoma and leiomyoma [5,7].…”

Section:  Discussionmentioning

confidence: 74%

Cervical intranodal schwannoma – a rare diagnosis

Mirea

Manea²,

Bejinariu³

et al. 2022

Rom J Morphol Embryol

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Intranodal schwannoma is a rare benign tumor, which originates from the peripheral nerve sheath (Schwann cells), fewer cases being reported with lymphatic involvement. We present the case of a middle-aged female patient, with one-year growing mass in the lateral-cervical area, in intimate relation with the vascular package of the neck. Preoperative cervical computed tomography examination showed the tumor features. There was no intraoperative complication, with the piece being completely removed. The morphological examination revealed the structure of a lymph node, and after Hematoxylin-Eosin staining, there were eosinophilic cytoplasm, euchromatic nuclei, with round, elongated or slightly wavy form and reduced pleomorphism, rare degenerative nuclear atypia, and no mitotic activity nor necrosis. The expression of S100 protein on immunohistochemistry, along with negative results for smooth muscle actin and desmin sustained the diagnosis of intranodal schwannoma of the neck. With a low index of cellular proliferation (Ki67), this case is in line with the reported features of schwannoma having extremely rare malignant transformation.

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