Intranasal/subcutaneous prime-booster immunization with Outer Membrane Vesicles of Meningococci C elicits high-avidity, persistent antibodies against Meningococci B
Abstract:Introduction: Neisseria meningitidis causes Invasive Meningococcal Disease (IMD). Immunization should achieve a persistent immune response against pathogens, at local and systemic levels, which can be modulated by administration site and appropriate adjuvants. Dimethyldioctadecylammonium bromide is a cationic lipid with adjuvant properties that can be used in as vesicles (DDA) or bilayer fragments (DDA-BF). Prime-booster scheme induces local and systemic antibodies.Objective: Testing the persistence of antibod… Show more
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