Intranasal Oxytocin as an Adjunct to Risperidone in Patients with Schizophrenia

Modabbernia, Amirhossein; Rezaei, Farzin; Salehi, Bahman; Jafarinia, Morteza; Ashrafi, Mandana; Tabrizi, Mina; Hosseini, Seyed Mohammad; Tajdini, Masih; Ghaleiha, Ali; Akhondzadeh, Shahin

doi:10.1007/s40263-012-0022-1

Cited by 94 publications

(99 citation statements)

References 35 publications

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“…A positive correlation between SZ progression and oxytocin levels in the central nervous system has been observed [Beckmann et al, 1985], and it is plausibly explained by a decreased sensitivity to the hormone [Glovinsky et al, 1994;Sasayama et al, 2012;Strauss et al, 2015]. Treatment with oxytocin indeed improves the performance of verbal memory learning tasks in SZ patients [Feifel et al, 2012], and attenuates the negative symptoms of the disease [Feifel et al, 2010;Modabbernia et al, 2013;Davis et al, 2014;Gibson et al, 2014].…”

Section: Behavioral Traits and Neuroendocrine Impairmentmentioning

confidence: 95%

Schizophrenia and Human Self-Domestication: An Evolutionary Linguistics Approach

et al. 2017

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Schizophrenia (SZ) is a pervasive neurodevelopmental disorder that entails social and cognitive deficits, including marked language problems. Its complex multifactorial etiopathogenesis, including genetic and environmental factors, is still widely uncertain. SZ incidence has always been high and quite stable in human populations, across time and regardless of cultural implications, for unclear reasons. It has been hypothesized that SZ pathophysiology may involve the biological components that changed during the recent human evolutionary history, and led to our distinctive mode of cognition, which includes language skills. In this paper we explore this hypothesis, focusing on the self-domestication of the human species. This has been claimed to account for many human-specific distinctive traits, including aspects of our behavior and cognition, and to favor the emergence of complex languages through cultural evolution. The “domestication syndrome” in mammals comprises the constellation of traits exhibited by domesticated strains, seemingly resulting from the hypofunction of the neural crest. It is our intention to show that people with SZ exhibit more marked domesticated traits at the morphological, physiological, and behavioral levels. We also show that genes involved in domestication and neural crest development and function comprise nearly 20% of SZ candidates, most of which exhibit altered expression profiles in the brain of SZ patients, specifically in areas involved in language processing. Based on these observations, we conclude that SZ may represent an abnormal ontogenetic itinerary for the human faculty of language, resulting, at least in part, from changes in genes important for the domestication syndrome and primarily involving the neural crest.

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Section: Behavioral Traits and Neuroendocrine Impairmentmentioning

confidence: 95%

Schizophrenia and Human Self-Domestication: An Evolutionary Linguistics Approach

et al. 2017

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“…For the cholinergic system, drugs that activate cholinergic receptors, including partial alpha 7-nicotinic agonists, currently show the most promise. Finally, exogenous oxytocin (delivered by intranasal spray) has been found to improve negative symptoms in two studies (Feifel 2012;Modabbernia et al 2013). It should be noted, however, that the relevant studies typically used older trial design and assessment methods, and many of them targeted cognition or social cognition, rather than negative symptoms, as the primary treatment outcome.…”

Section: Recent Developmentsmentioning

confidence: 99%

Motivational Deficits and Negative Symptoms in Schizophrenia: Concepts and Assessments

Reddy

Horan

Green

2015

Behavioral Neuroscience of Motivation

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Recent years have seen a resurgence of interest in motivational disturbances in schizophrenia . This is largely driven by the recognition that these disturbances are central to the "experiential" subdomain of negative symptoms and are particularly important determinants of functional disability. Research into the causes and treatment of experiential negative symptoms is therefore a high priority. This chapter reviews findings from experimental psychopathology and affective science relevant to understanding the neurobehavioral processes that underlie these negative symptoms. We focus on abnormalities in four processes that have received the most attention as likely contributors: anticipatory pleasure, reward learning, effort-based decision-making, and social motivation. We also review the research literature on pharmacological and psychosocial approaches to reduce functional deficits attributable to negative symptoms. Translational research is beginning to inform the development of new treatments specifically designed to target the experiential subdomain of negative symptoms.

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“…22,23 There has been much investigation of the possible benefits of intranasal oxytocin for schizophrenia, 24 with improvements recorded in domains such as clinical symptom ratings 25 and social cognition. 26 Intranasal oxytocin has also been studied for autism.…”

Section: Intranasal Oxytocinmentioning

confidence: 99%

Intranasal Drug Delivery in Neuropsychiatry: Focus on Intranasal Ketamine for Refractory Depression

Andrade¹

2015

J. Clin. Psychiatry

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Intranasal Oxytocin as an Adjunct to Risperidone in Patients with Schizophrenia

Cited by 94 publications

References 35 publications

Schizophrenia and Human Self-Domestication: An Evolutionary Linguistics Approach

Schizophrenia and Human Self-Domestication: An Evolutionary Linguistics Approach

Motivational Deficits and Negative Symptoms in Schizophrenia: Concepts and Assessments

Intranasal Drug Delivery in Neuropsychiatry: Focus on Intranasal Ketamine for Refractory Depression

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