Intranasal fluticasone propionate versus loratadine in the treatment of adolescent patients with seasonal allergic rhinitis

Jordana, Gloria; Dolovich, J.; Briscoe, Maureen P.; Day, James H.; Drouin, M.; Gold, Milton; Robson, Reid; Stepner, Nate M; Yang, William H.

doi:10.1016/s0091-6749(96)70303-2

Cited by 43 publications

(34 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Oral decongestants are indicated in combination with oral antihistamines for nasal congestion, but patients should be monitored for serious side effects. [14] Topically applied intranasal decongestants should be limited in use to less than 10 days because of rhinitis medicamentosa, which is rebound swelling of the nasal membranes or drug induced rhinitis. [15,16] Intranasal corticosteroids are often required in moderate to severe disease and are effective in reducing all symptoms of allergic rhinitis in addition to eye symptoms associated with allergic conjunctivitis.…”

Section: Discussionmentioning

confidence: 99%

Quality of life in patients with persistent allergic rhinitis treated with desloratadine monotherapy or desloratadine plus montelucast combination

Erdoğan

Şanlı²,

Paksoy³

et al. 2014

Kulak Burun Bogaz Ihtis Derg

View full text Add to dashboard Cite

Objectives: This study aims to compare the effectiveness of desloratadine monotherapy and desloratadine plus montelukast combination therapy on quality of life in patients with persistent allergic rhinitis. Patients and Methods:This study consists of 40 patients (28 females, 12 males, mean age 29.8 years; range 17 to 44 years) referred to ear, nose, and throat outpatient clinic between May 2010 and September 2010. A six-week randomized, doubleblind, cross-sectional study was performed in two arms: In group 1, 20 patients received desloratadine (5 mg/d) alone; in group 2, 20 patients received desloratadine (5 mg) plus montelukast (10 mg) combination therapy. Quality of life was assessed on the day before starting treatment and on the last day of each treatment period using the Rhinoconjunctivitis Quality of Life Questionnaire and Nighttime Symptom Scores. Results:In group 1, the mean quality of life scores before and after treatment were 3.17 and 2.43, respectively. In group 2, the mean quality of life scores before and after treatment were 2.94 and 1.73, respectively. Conclusion:Desloratadine plus montelukast combination therapy may have a positive impact on quality of life, sleep symptoms in particular.Keywords: Desloratadine; montelukast; persistent allergic rhinitis; quality of life.Amaç: Bu çalışmada inatçı alerjik rinit hastalarında desloratadin monoterapisi ve desloratadin artı montelukast kombinasyon tedavisinin yaşam kalitesi üzerine etkinliği karşılaştırıldı. Bulgular: Grup 1'de tedavi öncesi ve sonrası ortalama yaşam kalitesi skoru, sırasıyla 3.17 ve 2.43 idi. Grup 2'de ise, tedavi öncesi ve sonrası ortalama yaşam kalitesi skoru, sırasıyla 2.94 ve 1.73 idi.Sonuç: Desloratadin artı montelukast kombinasyon tedavisinin, özellikle uyku semptomları olmak üzere, yaşam kalitesi üzerine olumlu bir etkisi olabilir.Anahtar Sözcükler: Desloratadin; montelukast; inatçı allerjik rinit; yaşam kalitesi.

show abstract

Section: Discussionmentioning

confidence: 99%

Quality of life in patients with persistent allergic rhinitis treated with desloratadine monotherapy or desloratadine plus montelucast combination

Erdoğan

Şanlı²,

Paksoy³

et al. 2014

Kulak Burun Bogaz Ihtis Derg

View full text Add to dashboard Cite

show abstract

“…Most studies show treatment with intranasal corticosteroids to be more effective than antihistamines, especially for the control of nasal congestion. [9][10][11][12] Two leukotriene receptor antagonists (montelukast and zafirlukast) are currently approved for use in the United *Data are presented as median (range) of median total symptom scores over 14 days of treatment with fluticasone propionate or loratadine plus montelukast sodium. Daily symptom scores were the sum of the morning and evening scores.…”

Section: Commentmentioning

confidence: 99%

Fluticasone Nasal Spray and the Combination of Loratadine and Montelukast in Seasonal Allergic Rhinitis

Saengpanich¹,

deTineo²,

Naclerio³

et al. 2003

Arch Otolaryngol Head Neck Surg

View full text Add to dashboard Cite

show abstract

“…It is useful to add objective findings from nasal examinations to the subjective symptom scores. Cytology examination [18], rhinoscopy [19], nasal provocation testing [20], and the measurement of nasal inspiratory peak flow [21] have been used. However, many of these methods have not been validated for use in combination with subjective symptom scores.…”

Section: Literature Review: Grading Nasal Symptom Severity In Allergimentioning

confidence: 99%

Grading the severity of allergic rhinitis for treatment strategy and drug study purposes

Okuda

2001

Curr Allergy Asthma Rep

View full text Add to dashboard Cite

Grading the severity of rhinitis symptoms is essential for the evaluation of drug efficacy. However, a uniform grading system has not been standardized. A review of 44 journal articles and symposia from Japan, Copenhagen, and the World Health Organization indicates major differences among systems. All except the World Health Organization used a sum of rhinitis scores. The lack of standardization limits comparisons of subjective symptom changes after comparable treatments. Corrective measures include the use of evidence-based definitions of independent nasal symptoms, avoidance of biases in evaluation, and establishment of international consensus for a standardized scale in this era of globalization.

show abstract

Intranasal fluticasone propionate versus loratadine in the treatment of adolescent patients with seasonal allergic rhinitis

Cited by 43 publications

References 8 publications

Quality of life in patients with persistent allergic rhinitis treated with desloratadine monotherapy or desloratadine plus montelucast combination

Quality of life in patients with persistent allergic rhinitis treated with desloratadine monotherapy or desloratadine plus montelucast combination

Fluticasone Nasal Spray and the Combination of Loratadine and Montelukast in Seasonal Allergic Rhinitis

Grading the severity of allergic rhinitis for treatment strategy and drug study purposes

Contact Info

Product

Resources

About