Fluticasone Nasal Spray and the Combination of Loratadine and Montelukast in Seasonal Allergic Rhinitis

Abstract

Both treatments provided clinically meaningful responses, but the overall results favored fluticasone propionate.

Allergic Rhinitis and its Impact on Asthma (ARIA) 2008*

“…The combination of oral H 1 -antihistamines and leukotriene receptor antagonists does not increase the efficacy of any single drug and is less effective than intranasal corticosteroids (1594,1596,1597). The combination of ipratropium with beclomethasone dipropionate is more effective than either active agent alone in the treatment of rhinorrhoea (1598).…”

Montelukast: Pharmacology, Safety, Tolerability and Efficacy

“…60 When fluticasone propionate nasal spray was evaluated in relationship to a combination of loratadine/montelukast, median total nasal symptom scores were not statistically significantly different but scores in a quality of life questionnaire were better and the eosinophil count and eosinophilic cationic protein counts were lower in the fluticasone group. 63 Combination therapy has also been assessed in patients with asthma. In a study comparing montelukast to budesonide alone (in 400 or 800 µg bid) and to combination montelukast/budesonide (400 µg bid), bronchial reactivity was improved in all of the budesonide groups in comparison to the montelukast group while there were no differences between the budesonide groups.…”

Treatment of Allergic Rhinitis: Anticholinergics, Glucocorticotherapy, Leukotriene Antagonists, Omalizumab and Specific-Allergen Immunotherapy

“…The results were significantly better in the fluticasone group in the reduction of nasal symptoms (Saengpanich et al, 2003).…”