Intranasal distribution and clearance of thermoreversible gel in an animal model

Choi, Ji Eun; Kim, Ki Ryung; Noh, Yangseop; Chung, Wingyan; Cho, Yang-Sun; Chung, Seung‐Kyu; Dhong, Hun‐Jong; Kim, Hyo Yeol

doi:10.1002/alr.21944

Cited by 1 publication

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References 17 publications

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“…Its low viscosity ensures that the drug is easy to use, can be evenly distributed in the periodontal pocket, and adequately infiltrates the drug solution into the periodontal pocket. In addition to ensuring the therapeutic effect of drugs in the oral cavity, maintaining the required concentration of drugs in the administration site for a long period is necessary [ 37 , 83 ].…”

Section: Subjectsmentioning

confidence: 99%

An Overview on Thermosensitive Oral Gel Based on Poloxamer 407

et al. 2021

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In this review, we describe the application of thermosensitive hydrogels composed of poloxamer in medicine, especially for oral cavities. Thermosensitive hydrogels remain fluid at room temperature; at body temperature, they become more viscous gels. In this manner, the gelling system can remain localized for considerable durations and control and prolong drug release. The chemical structure of the poloxamer triblock copolymer leads to an amphiphilic aqueous solution and an active surface. Moreover, the poloxamer can gel by forming micelles in an aqueous solution, depending on its critical micelle concentration and critical micelle temperature. Owing to its controlled-release effect, a thermosensitive gel based on poloxamer 407 (P407) is used to deliver drugs with different characteristics. As demonstrated in studies on poloxamer formulations, an increase in gelling viscosity decreases the drug release rate and gel dissolution time to the extent that it prolongs the drug’s duration of action in disease treatment. This property is used for drug delivery and different therapeutic applications. Its unique route of administration, for many oral diseases, is advantageous over traditional routes of administration, such as direct application and systemic treatment. In conclusion, thermosensitive gels based on poloxamers are suitable and have great potential for oral disease treatment.

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Section: Subjectsmentioning

confidence: 99%