An Overview on Thermosensitive Oral Gel Based on Poloxamer 407

Abstract

In this review, we describe the application of thermosensitive hydrogels composed of poloxamer in medicine, especially for oral cavities. Thermosensitive hydrogels remain fluid at room temperature; at body temperature, they become more viscous gels. In this manner, the gelling system can remain localized for considerable durations and control and prolong drug release. The chemical structure of the poloxamer triblock copolymer leads to an amphiphilic aqueous solution and an active surface. Moreover, the poloxamer can gel by forming micelles in an aqueous solution, depending on its critical micelle concentration and critical micelle temperature. Owing to its controlled-release effect, a thermosensitive gel based on poloxamer 407 (P407) is used to deliver drugs with different characteristics. As demonstrated in studies on poloxamer formulations, an increase in gelling viscosity decreases the drug release rate and gel dissolution time to the extent that it prolongs the drug’s duration of action in disease treatment. This property is used for drug delivery and different therapeutic applications. Its unique route of administration, for many oral diseases, is advantageous over traditional routes of administration, such as direct application and systemic treatment. In conclusion, thermosensitive gels based on poloxamers are suitable and have great potential for oral disease treatment.

New Formulations Loading Caspofungin for Topical Therapy of Vulvovaginal Candidiasis

“…The advantage of joining both polymers would let us to obtain a hydrogel with optimal biocompatible and biodegradable nature, high-water content, high responsiveness and permeability, and then obtain an improved therapeutic effect [ 44 ]. Both polymers are linked by non-covalent interactions between the amino groups of CTS and the ethylene oxide units of P407 to form a high-strength physical [ 45 ]. The combination of these polymers has also been used for drug delivery, including vaginal administration [ 46 , 47 , 48 , 49 ].…”

The Effect of Coenzyme Q10/Collagen Hydrogel on Bone Regeneration in Extraction Socket Prior to Implant Placement in Type II Diabetic Patients: A Randomized Controlled Clinical Trial

“…This should be attributed to the fact that poloxamer 407 is a thermoresponsive hydrogel. At high temperature (37 °C), the sol-gel transition from aqueous solution occurs [ 54 ]. Poloxamer 407 exists as monomers in the solution.…”

Poloxamer-Based Scaffolds for Tissue Engineering Applications: A Review

“…The rheological properties of poloxamers have led to their application in injectable stents and bio-inks [ 44 , 45 ]. In the research of poloxamer in situ hydrogels, the injectability and stability of hydrogels are critical elements [ 14 ]. Gelation time is the time of the change from a liquid to a hydrogel over injection at a constant temperature (36.5 °C).…”

“…The amphiphilicity, reversible thermal responsiveness, and micellar self-assembly behavior of poloxamers allow the formation of micelles with ordered structures, thereby encapsulating the drug for delivery [ 12 , 13 , 14 , 15 ]. In recent years, besides being carriers for drug delivery, poloxamer hydrogels have shown great application prospects in tissue engineering as injectable scaffolds loaded with cells and GFs [ 11 ].…”