Intranasal delivery of streptomycin sulfate (STRS) loaded solid lipid nanoparticles to brain and blood

Kumar, Mukesh; Kakkar, Vandita; Mishra, Anil K.; Chuttani, Krishna; Kaur, Indu Pal

doi:10.1016/j.ijpharm.2013.11.038

Cited by 65 publications

(32 citation statements)

References 37 publications

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“…The phospholipid envelop of NLC acts as the barrier, which has restricted the penetration of release media and reduced the faster immobilization of cedrol from the compritol-triolein core extending the release. 57 To measure the efficiency of the formulation NLC-C 1 and NLC-C 2 , in vitro release of cedrol from NLC was conducted in stimulated physiological dissolution medium. The results obtained were further analyzed by using different mathematical models for drug release kinetics.…”

Section: In Vitro Release Study Of Cedrol From Nlcmentioning

confidence: 99%

Inhibitory effect of a new orally active cedrol-loaded nanostructured lipid carrier on compound 48/80-induced mast cell degranulation and anaphylactic shock in mice

Chakraborty¹,

Kar²,

Kumari³

et al. 2017

IJN

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Background Type I hypersensitivity is an allergic reaction characterized by the overactivity of the immune system provoked by normally harmless substances. Glucocorticoids, anti-histamines, or mast cell stabilizers are the choices of treatment for type I hypersensitivity. Even though these drugs have the anti-allergic effect, they can have several side effects in prolong use. Cedrol is the main bioactive compound of Cedrus atlantica with anti-tumor, anti-oxidative, and platelet-activating factor inhibiting properties. Methods In this study, the preparation and anti-anaphylactic effect of cedrol-loaded nanostructured lipid carriers (NLCs) were evaluated. NLCs were prepared using Compritol ® 888 ATO and triolein as lipid phase and vitamin E d -α-tocopherylpolyethyleneglycol 1000 succinate, soya lecithin, and sodium deoxycholate as nanoparticle stabilizers. Results The average diameter of cedrol-NLCs (CR-NLCs) was 71.2 nm (NLC-C 1 ) and 91.93 nm (NLC-C 2 ). The particle had negative zeta potential values of −31.9 mV (NLC-C 1 ) and −44.5 mV (NLC-C 2 ). Type I anaphylactoid reaction in the animal model is significantly reduced by cedrol and cedrol-NLC. This in vivo activity of cedrol resulted that cedrol suppressed compound 48/80-induced peritoneal mast cell degranulation and histamine release from mast cells. Furthermore, compound 48/80-evoked Ca 2+ uptake into mast cells was reduced in a dose-dependent manner by cedrol and cedrol-NLC. Studies confirmed that the inhibition of type I anaphylactoid response in vivo in mice and compound 48/80-induced mast cell activation in vitro are greatly enhanced by the loading of cedrol into the NLCs. The safety of cedrol and CR-NLC was evaluated as selectivity index (SI) with prednisolone and cromolyn sodium as positive control. SI of CR-NLC-C 2 was found to be 11.5-fold greater than both prednisolone and cromolyn sodium. Conclusion Administration of CR-NLC 24 hours before the onset of anaphylaxis can prevent an anaphylactoid reaction. NLCs could be a promising vehicle for the oral delivery of cedrol to protect anaphylactic reactions.

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Section: In Vitro Release Study Of Cedrol From Nlcmentioning

confidence: 99%

Inhibitory effect of a new orally active cedrol-loaded nanostructured lipid carrier on compound 48/80-induced mast cell degranulation and anaphylactic shock in mice

Chakraborty¹,

Kar²,

Kumari³

et al. 2017

IJN

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“…Earlier we explored solid lipid nanoparticles (SLNs) as carrier systems for a wide variety of water soluble and insoluble drug molecules (Kakkar et al, , 2011Singh et al, 2013) like curcumin (prone to intestinal metabolism and high hepatic degradation and clearance), streptomycin (prone to acid degradation) and ketoconazole (completely insoluble lipophilic molecule; unpublished work) with great success (Bhandari and Kaur, 2013a;Kumar et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Nano-formulation of rifampicin with enhanced bioavailability: Development, characterization and in-vivo safety

Singh

Jindal

Singh

et al. 2015

International Journal of Pharmaceutics

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“…The basic principle behind this technique is that when the sample undergoes a physical transformation (such as melting, crystal transformation, desolvation), the system will be changed, changing its enthalpy, resulting in thermal effects. DSC measures the heat flow into or from the sample when it is heated or cooled and then provides qualitative and quantitative information about physicochemical changes [39]. There is no detectable endotherm if the drug is present in a molecular dispersion or solid solution state in polymeric microspheres [40].…”

Section: Differential Scanning Calorimetrymentioning

confidence: 99%

Optimization and Evaluation of Monodispersed Tetrandrine- Loaded PLA Microspheres Prepared With A SPG Membrane Emulsification Technique

Jin¹,

Yin²,

Zhang³

et al. 2017

SOJPPS

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Research articlewidely in vivo without a targeting effect, thus tetrandrine in this formulation does not concentrate highly in diseased organs or tissues [6][7] and usually causes pain or phlebitis. To improve pulmonary drug concentration to maximize its effectiveness and minimize the adverse side effects, tetrandrine polylactic acid microspheres with diameters of 7-15 μm were injected intravenously to achieve lung targeting [8]. This mechanism of lung targeting by injecting more than 7 μm microspheres occurs through mechanical filtration by the pulmonary capillaries, which can damage the lung permanently. Microspheres with diameters between 0.5-5 μm used for pulmonary inhalation could overcome this shortcoming. However, the controllability and uniformity of the microsphere size are closely related to the effects of pulmonary inhalation. The particle size is difficult to control for microspheres prepared by conventional methods, such as emulsification, ultrasonic emulsifying preparation and distribution [9].Recently, a novel method, the Shirasu Porous Glass (SPG) membrane emulsification technique, has been widely applied to the preparation of uniform-sized emulsions. Uniform droplet size and high drug encapsulation efficiency have been obtained by permeating a dispersed phase into a continuous phase through an SPG membrane at an adequate pressure [10][11][12][13][14]. Optimization and Evaluation of Monodispersed AbstractTo improve pulmonary drug concentrations and to maximize the effectiveness and minimize the adverse side effects, uniformsized tetrandrine-loaded polylactide (PLA) microspheres with a suitable particle size for pulmonary inhalation were prepared by the Shirasu Porous Glass (SPG) membrane emulsification technique. The main parameters influencing PLA microsphere properties were investigated: transmembrane pressure, circulation speed, high hydrophilic-lipophilic balance (HLB value), PLA concentration and oil-water volume ratio. Narrowly size-distributed tetrandrine-loaded PLA microspheres were obtained with a high drug encapsulation efficiency of 81.0% and an average diameter of 3.16 μm under optimized conditions. The results of Fourier transform infrared, differential scanning calorimetry and powder X-ray diffraction revealed that tetrandrine would be either molecularly dispersed in the polymer or distributed in an amorphous form. Further, the in vitro drug release experiment confirmed that the uniform-sized tetrandrine-loaded PLA microspheres showed suppressed burst release. These studies provide a basis for the use of uniformly sized 3.16 μm tetrandrine-loaded PLA microspheres for pulmonary inhalation.

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Intranasal delivery of streptomycin sulfate (STRS) loaded solid lipid nanoparticles to brain and blood

Cited by 65 publications

References 37 publications

Inhibitory effect of a new orally active cedrol-loaded nanostructured lipid carrier on compound 48/80-induced mast cell degranulation and anaphylactic shock in mice

Inhibitory effect of a new orally active cedrol-loaded nanostructured lipid carrier on compound 48/80-induced mast cell degranulation and anaphylactic shock in mice

Nano-formulation of rifampicin with enhanced bioavailability: Development, characterization and in-vivo safety

Optimization and Evaluation of Monodispersed Tetrandrine- Loaded PLA Microspheres Prepared With A SPG Membrane Emulsification Technique

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