Intranasal Delivery of Mesenchymal Stem Cells Significantly Extends Survival of Irradiated Mice with Experimental Brain Tumors

Balyasnikova, Irina V.; Prasol, Melanie S.; Ferguson, Sherise D.; Han, Yu; Ahmed, Atique U.; Gutova, Margarita; Tobias, Alex L.; Mustafi, Devkumar; Rincón, Esther; Zhang, Lingjiao; Aboody, Karen S.; Lesniak, Maciej S.

doi:10.1038/mt.2013.199

Cited by 113 publications

(118 citation statements)

References 44 publications

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“…[ 11,35 ] We have shown the homing property of the MNPs labeled MSCs in LPS induced infl ammation model and also in subcutaneous prostate tumor model for both small tumor (≈50 mm 3 ) as well as large tumors (≈500 mm 3 ). This indicates its potential application for diagnosis and treatment of both primary tumors as well as smallsized metastatic tumors.…”

Section: Discussionmentioning

confidence: 83%

Magnetic Nanoparticles Labeled Mesenchymal Stem Cells: A Pragmatic Solution toward Targeted Cancer Theranostics

Singh

Jain

Senapati

et al. 2015

Adv Healthcare Materials

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Mesenchymal stem cells (MSCs) have gained much interest to be used as targeting vehicle in cancer therapy due to the intrinsic tumor-homing behavior associated with them. In this scenario, superparamagnetic nanoparticles are emerging as an ideal probe for noninvasive cell tracking for different stem cell applications. In the study, it is demonstrated that the formulated aqueous dispersible glyceryl monooleate coated magnetic nanoparticles (MNPs) can act as a better labeling and efficient tracking agent without affecting the inherent properties of MSCs. The MNPs-MSCs facilitate the stem cell tracking by magnetic resonance imaging at a very low cell number having high T relaxivity and potentiates the use of MNPs-MSCs as a prospective diagnostic tool. Most importantly, the homing of MNPs-MSCs toward inflammation site, subcutaneous prostate tumor (small as well as large tumor), and in orthotopic prostate tumor suggests the clinical relevance of the system. In addition, intraperitoneal delivery of MNPs-MSCs shows enhanced tumor accumulation and less sequestration in liver as revealed by in vivo imaging and histological studies. The results here demonstrate that MNPs-MSCs may prove as a better targeted delivery agent for early diagnosis of tumors even of smaller size.

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Section: Discussionmentioning

confidence: 83%

Magnetic Nanoparticles Labeled Mesenchymal Stem Cells: A Pragmatic Solution toward Targeted Cancer Theranostics

Singh

Jain

Senapati

et al. 2015

Adv Healthcare Materials

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“…Example is in the case of brain tumors in which the intra nasal route of SC is now becoming a novel route of administrations [209,210]. In cancer bearing mice another strategy is introduced to encapsulate the SC in vivo studies.…”

Section: Encapsulation Of Stem Cellsmentioning

confidence: 99%

Development of Anti-Cancer Stem Cells as Theranostic Agents in the Treatment of Different Cancer Types: An Update

Malik¹,

Rasool²,

Khan³

et al. 2017

J Carcinog Mutagen

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Various unprecedented anti-tumor potential targets that robustly target cancer cells while sparing normal cells have been produced by biomedical research in cancer therapeutic intervention for interrupting disease progression and their cure. Stem cells characterize an accessible cell source for novel cell based clinical therapies by inhibiting tumor progression signalling pathways. They carry distinctive characteristics of isolation and migration to tissue inflammation site, inherited modifiability and protein expression. Stem cells are also used in immune-reconstitution and tissue regeneration. Implication of different types of stem cells as an attractive candidate for targeted delivery of anti-neoplastic agents has emerged as a promising field in anticancer therapy. Mutual interaction between cancer cells and stem cells results in effective and safer clinical therapy for tumors. Keeping in view, this review highlights the potential role of stem cells in the progression of tumor metastasis and also summarizes the role of different signaling pathways in carcinogenesis and their involvement in disease treatment. It also focuses on the current advances in stem cells practice in therapeutics of cancer.

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“…Coculture of GBM43 and U87 glioma cells with MSCs-TRAIL displayed notable rise in caspase-3 activity. Survival rate of tumor-bearing mice was enhanced intranasally delivered with MSCs-TRAIL [25]. Carbenoxolone (CBX), a derivative of 18-glycyrrhetinic acid, has been shown to effectively enhance killing activity of TRAIL-express-ing MSCs.…”

Section: Proliferative and Antiproliferative Pathways And Their Rolesmentioning

confidence: 99%

Critical Molecular and Genetic Markers in Primary Brain Tumors with Their Clinical Importance

Yaylım¹,

Azam²,

Farooqı³

et al. 2016

Neurooncology - Newer Developments

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Classification of primary brain tumors is based mainly on histopathological characteristics. Due to the peculiarity of the central nervous system (CNS), the location of the tumor is also used in the naming of the CNS tumors. These features, histopathology, and location determine the main prognostic factors in these tumors. Updated molecular and genetic findings in the last two decades accumulated vast amount of knowledge about the biological behavior, response to the treatment, and consequently the prognosis of CNS tumors. After the clinical use of these data, a recent classification is proposed by the International Society of Neuropathology named as "integrated diagnosis."This classification considers the histopathological classification, World Health Organization (WHO) grade along with the molecular information. The emerging molecular-genetic data about the CNS tumors will allow the translational researchers to deliberately understand the oncogenic mechanisms involved in the evolution of these tumors and judge the optional treatment strategies.Evaluating the check points of cell cycle and apoptosis provides valuable information about the tumor biology (tumorigenesis). These mechanisms (pathways) also play an exclusive role in CNS tumors. Knowledge concerning the gene repressors and gene activators or some epigenetic changes in proliferative and antiproliferative pathways that regarded gliomas may yield new individualized treatment options.In this chapter, we will review the basic and translational research molecular-genetic data of gliomas with special interest on proliferative and antiproliferative pathways. Further emerging treatment options and treatment responses in gliomas will be © 2016 The Author(s). Licensee InTech. This chapter is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.critically evaluated with regard to their histopathology, anatomical location, and molecular-genetic fingerprints.

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Intranasal Delivery of Mesenchymal Stem Cells Significantly Extends Survival of Irradiated Mice with Experimental Brain Tumors

Cited by 113 publications

References 44 publications

Magnetic Nanoparticles Labeled Mesenchymal Stem Cells: A Pragmatic Solution toward Targeted Cancer Theranostics

Magnetic Nanoparticles Labeled Mesenchymal Stem Cells: A Pragmatic Solution toward Targeted Cancer Theranostics

Development of Anti-Cancer Stem Cells as Theranostic Agents in the Treatment of Different Cancer Types: An Update

Critical Molecular and Genetic Markers in Primary Brain Tumors with Their Clinical Importance

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