Intranasal Administration of Peptides: Nasal Deposition, Biological Response, and Absorption of Desmopressin

Harris, Alice C.; Nilsson, Inga Marie; Wagner, Zoltán; Alkner, U.

doi:10.1002/jps.2600751113

Cited by 146 publications

(57 citation statements)

References 16 publications

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“…This mechanism of MCC influences the process of absorption because of the dissolved drugs in the nasal cavity which is released by both cilia and mucus 19 . It has also been observed in many studies that deposition of molecules in the anterior end of the cavity decreases MCC, leading to increase in absorption and bioavailability 20,21 . Likewise, also due to the presence of enzymes such as peptidasesExo-peptidases (mono and diamino-peptidases), which cleave the peptides at N and C terminal and endo-peptidases (serine and cysteine) cleaves the internal peptide bond, in the lumen of the nasal cavity, causes low transport of these biomolecules leading to low absorption of therapeutic molecules.…”

Section: Mechanism Of Drug Absorption Through Indd Routementioning

confidence: 90%

Untitled

2017

IJPSR

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Intra nasal drug delivery system (INDDS) has emerged as a noninvasive alternative for delivering peptides, proteins and other therapeutic agents, specifically to CNS (Central nervous system). This route is well suitable for systemic delivery because of high vasculature, permeability, elimination of hepatic first pass metabolism and low enzymatic environment of the nasal cavity. This route of delivery is especially suited to treat CNS disorders like -neurodegenerative diseases, mood disorders, cognitive dysfunctioning etc., due to drugs ability to directly reach the brain by passing blood brain barrier (BBB). It is also a well suited delivery route for the biotechnological products like DNA plasmids, hormone, proteins, peptides, DNA vaccines to give enhanced bioavailability. A wide variety of therapeutic compounds may be administered intra-nasally for topical, systemic and CNS disorders. In this review, we have focussed on the nasal passage anatomical pathway leading to CNS drug delivery, different factors affecting nasal absorption, bioavailability barriers, vaccines and other therapeutic, biologically active molecules delivered via intra nasal route and strategies to improve nasal absorption. We have also outlined various in vitro and in vivo cellular models for nasal drug absorption and permeability studies.

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Section: Mechanism Of Drug Absorption Through Indd Routementioning

confidence: 90%

Untitled

2017

IJPSR

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“…Enhancing mechanisms include decrease in mucociliary clearance, reduction of mucus viscosity or elasticity, inhibition of enzyme activity, opening of tight junctions, and solubilization or stabilization of the drug molecule [11][12][13][14][15][16][17][18][19][20][21][22][23][24]. Mucociliary clearance can be defined as combined actions of the mucus layer and the cilia, which is an important factor in the physiological defence of the respiratory tract against inhaled hazardous particles [13].…”

Section: Limitations Of Nasal Deliverymentioning

confidence: 99%

“…The use of bioadhesive excipients in the formulations is an approach to overcome rapid mucociliary clearance. Depositing the formulation in the anterior, less ciliated part of the nasal cavity may also reduce the clearance and thus improved the absorption [17,18]. Metabolic enzymes in the nasal mucosa may also limit the bioavailability of some drugs particularly peptides and proteins [19].…”

Section: Limitations Of Nasal Deliverymentioning

confidence: 99%

Nasal Inserts for Drug Delivery: An Overview

Algin-Yapar¹

2014

Trop. J. Pharm Res

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“…Their humidifying effect is convenient and useful, since many allergic and chronic diseases are often connected with crusts and drying of mucous membranes. Microbiological stability, irritation and allergic rhinitis are the major drawbacks associated with the water based dosage forms because the required preservatives impair mucociliary function and the reduced chemical stability of the dissolved drug substance and the short residence time of the formulation in the nasal cavity are major disadvantages of liquid formulations 20 . The several types dosage forms available in liquid form are described below.…”

Section: Nasal Drug Delivery System Dosage Formsmentioning

confidence: 99%

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2012

IJPSR

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The recent advancement of nasal drug delivery systems has increased enormously and is gaining significant importance. Intranasal therapy has been an accepted form of treatment in the Ayurvedic system of Indian Medicine. The non-invasive delivery of nasal drug delivery systems made to exploit for the development of successful treatment. The advantages, disadvantages, mechanism of action and application of nasal drug delivery system in local delivery, systematic delivery, nasal vaccines and CNS delivery are explained lucidly. The relevant aspects of biological, physicochemical and pharmaceutical factors of nasal cavity that must be considered during the process of discovery and development of new drugs for nasal delivery as well as in their incorporation into appropriate nasal pharmaceutical formulations are also discussed. Nasal route is more suitable for those drugs which cannot be administered orally due to gastric degradation or hepatic first pass metabolism of the drug. Intranasal drug delivery is found much promising route for administration of peptides and protein drugs. Much has been investigated and much more are to be investigated for the recent advancement of nasal drug delivery systems.

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Intranasal Administration of Peptides: Nasal Deposition, Biological Response, and Absorption of Desmopressin

Cited by 146 publications

References 16 publications

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Nasal Inserts for Drug Delivery: An Overview

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