Intramyocardial transplantation of cardiac telocytes decreases myocardial infarction and improves post‐infarcted cardiac function in rats

Zhao, Bei; Liao, Zhaofu; Chen, Shang; Yuan, Ziqiang; Chen, Yilin; Lee, Kenneth K.; Qi, Xufeng; Shen, Xiaotao; Zheng, Xin; Quinn, Thomas; Cai, Dongqing

doi:10.1111/jcmm.12259

Cited by 87 publications

(87 citation statements)

References 37 publications

(54 reference statements)

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“…Moreover, this peculiar stromal cell type is being increasingly implicated in a wide range of pathologies with potential applications in regenerative medicine 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36. Telocyte possess unique ultrastructural features consisting of a small cell body and extremely long and thin prolongations, termed telopodes, displaying a moniliform aspect characterized by the alternation of thin segments (called podomers) and small dilated regions (called podoms) accommodating mitochondria, endoplasmic reticulum cisternae and caveolae 11, 12, 37.…”

Section: Introductionmentioning

confidence: 99%

Telocytes in normal and keratoconic human cornea: an immunohistochemical and transmission electron microscopy study

Marini

Mencucci

Rosa

et al. 2017

J Cellular Molecular Medi

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Telocytes (TC) are typically defined as cells with telopodes by their ultrastructural features. Their presence was reported in the interstitium of various organs in vertebrates, including humans. However, no study has yet described the presence of TC in the human eye and in particular, within the stromal compartment of the cornea. To address this issue, samples of normal and pathologic (keratoconic) human corneas were tested by immunohistochemistry for CD34, platelet‐derived growth factor receptor α (PDGFRα) and c‐kit/CD117 or examined by transmission electron microscopy. We found that TC coexpressing CD34 and PDGFRα were distributed throughout the whole normal corneal stroma with different TC subtypes being distinguishable on the basis of the expression of the stemness marker c‐kit (i.e. c‐kit‐positive and c‐kit‐negative TC subpopulations). Transmission electron microscopy examination confirmed the existence of spindle‐shaped and bipolar TC typically displaying two long and thin moniliform telopodes establishing intercellular contacts formed by gap junctions. Keratoconic corneas were characterized by ultrastructural damages and patchy loss of TC with an almost complete depletion of the c‐kit‐positive TC subpopulation. We propose that TC may contribute to the maintenance of corneal stromal homoeostasis and that, in particular, the c‐kit‐positive TC subtype might have stemness capacity participating in corneal regeneration and repair processes. Further studies are needed to clarify the differential roles of corneal TC subtypes as well as the possible therapeutic applications of TC in degenerative corneal disorders such as keratoconus.

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Section: Introductionmentioning

confidence: 99%

Telocytes in normal and keratoconic human cornea: an immunohistochemical and transmission electron microscopy study

Marini

Mencucci

Rosa

et al. 2017

J Cellular Molecular Medi

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“…Telocytes accompanying cardiomyocyte in primary culture: two-and three-dimensional culture environment [Zhou et al, 2010a] Cardiac telocytes were decreased during myocardial infarction and their therapeutic effects for ischaemic heart in rat [Zhao et al, 2013] Intramyocardial transplantation of cardiac telocytes decreases myocardial infarction and improves post-infarcted cardiac function in rats [Zhao et al, 2014] Comparative analysis of telomerase activity in CD117(+) CD34(+) cardiac telocytes with bone mesenchymal stem cells, cardiac fibroblasts and cardiomyocytes [Li et al, 2015] Histological and immunohistochemical study of cardiac telocytes in a rat model of isoproterenol-induced myocardial infarction with a reference to the effect of grape seed extract [Nour et al, 2017] J Cell Mol Med…”

Section: The Markers Used To Identify Cardiac Tcs Can Be Challengedmentioning

confidence: 99%

Myocardial Telocyte-Like Cells: A Review Including New Evidence

Iancu

Rusu

Mogoantă

et al. 2018

Cells Tissues Organs

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Telocytes (TCs) are a controversial cell type characterized by the presence of a particular kind of prolongations, known as telopodes, which are long, thin, and moniliform. A number of attempts has been made to establish the molecular phenotype of cardiac TCs (i.e., expression of c-kit, CD34, vimentin, PDGRFα, PDGRFβ, etc.). We designed an immunohistochemical study involving cardiac tissue samples obtained from 10 cadavers with the aim of determining whether there are TC-like interstitial cells that populate the interstitial space other than the mural microvascular cells. We applied the markers for CD31, CD34, PDGRFα, CD117/c-kit, and α-smooth muscle actin (α-SMA). We found that, in relation to two-dimensional cuts, the endothelial tubes could be misidentified as TC-like cells, the difference being the positive identification of endothelial lumina. Moreover, we found that cardiac pericytes express PDGRFα, CD117/c-kit, and α-SMA, and that they could also be misidentified as TCs when using light microscopy. We reviewed the respective values of the previously identified markers for achieving a clear-cut identification of cardiac TCs, highlighting the critical lack of specificity.

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“…Surprisingly, transplantation of TCs into the infarcted myocardium led to the decrease of the affected area, enhanced myocardial function (higher left ventricle ejection fraction), lowered fi nal diastolic diameters and fi nal systolic diameters (compared to control group) and increased density of TCs in infarct zone. Furthermore, angiogenesis was augmented and normal reconstruction of left ventricle, without excessive fi brosis, was stimulated (observed higher thickness of left ventricle in ischaemic zone and in border zone as well as lower collagen area in infarct zone compared to control group) (42). Thus, there exists a potential to reverse, at least partially, MI consequences.…”

Section: Current Achievements Of Tcs-related Experimental Therapiesmentioning

confidence: 94%

A comprehensive guide to telocytes and their great potential in cardiovascular system

Kucybała¹,

Janas²,

Ciuk³

et al. 2017

BLL

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Telocytes, a recently discovered type of interstitial cells, have a very distinctive morphology -the small cell body with long extensions, named telopodes. In our review, apart from introducing general aspects of telocytes, we focus on properties, functions and future potential of those cells in cardiovascular system. However, physiological functions of telocytes in cardiovascular system are still regarded as quite enigmatic. Previous studies claim that they play a role in organogenesis and regeneration, bioelectrical signalling, mechanoelectrical coupling, anti-oxidative protection, angiogenesis and regulation of blood fl ow. As well, they are presumably connected with the presence of blood-myocardium barrier and proper organisation of extracellular matrix. Moreover, there exists a signifi cant link between the quantity of telocytes in tissue and numerous cardiovascular diseases such as: myocardial infarction, cardiomyopathies, systemic sclerosis, heart failure, atrial fi brillation, isolated atrial amyloidosis, myxomatous valve degeneration and hyperplastic consequences of vascular injury. Thanks to their unique properties, telocytes might be a breakthrough in treatment of cardiovascular diseases, as they may be effective in reversing effects of myocardial infarction. Telocytes also may play a major role in tissue engineering -they might be the key factor in creating stable and effi cient vascular network in larger synthetic tissues or organs (Tab. 1, Fig. 3, Ref. 53). Text in PDF www.elis.sk.

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Intramyocardial transplantation of cardiac telocytes decreases myocardial infarction and improves post‐infarcted cardiac function in rats

Cited by 87 publications

References 37 publications

Telocytes in normal and keratoconic human cornea: an immunohistochemical and transmission electron microscopy study

Telocytes in normal and keratoconic human cornea: an immunohistochemical and transmission electron microscopy study

Myocardial Telocyte-Like Cells: A Review Including New Evidence

A comprehensive guide to telocytes and their great potential in cardiovascular system

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