Intramuscular sulfadoxine-pyrimethamine in uncomplicated chloroquine-resistant falciparum malaria during pregnancy

Sowunmi, A.; Akindele, J.A.; Omitowoju, G.O.; Omigbodun, Akinyinka; Oduola, A. M. J.; Salako, L.A.

doi:10.1016/0035-9203(93)90043-p

Cited by 14 publications

(2 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…1990). Chloroquine resistance was reported in the area in the 1980s (Ekanem 1985; Salako & Aderounmu 1987) and pyrimethamine–sulphadoxine resistance in the 1990s (Sowunmi et al. 1993, 1998a; Falade et al.…”

Section: Study Areamentioning

confidence: 99%

Open randomized study of pyrimethamine–sulphadoxine vs. pyrimethamine–sulphadoxine plus probenecid for the treatment of uncomplicated Plasmodium falciparum malaria in children

Sowunmi

Fehintola

Adedeji

et al. 2004

Tropical Med Int Health

Self Cite

View full text Add to dashboard Cite

Summarybackground Increasing drug resistance in Plasmodium falciparum has necessitated renewed search for cheap, effective alternatives to commonly available antimalarials, chloroquine and pyrimethaminesulphadoxine, for the treatment of malaria in Africa. Probenecid, an inhibitor of organic anion transporters and multiresistance-associated proteins, can chemosensitize P. falciparum to pyrimethamine and sulphadoxine in vitro, but the clinical significance is unclear. We assessed the safety, treatment efficacy, and effects on gametocyte carriage of adding probenecid to pyrimethaminesulphadoxine.methods We evaluated 151 children aged 12 years or younger who had uncomplicated P. falciparum malaria. Patients were randomly assigned pyrimethamine-sulphadoxine (25 mg/kg of the sulphadoxine component) or pyrimethamine-sulphadoxine as above plus probenecid 20-25 mg/kg of bodyweight in two divided doses daily for 3 days. The primary endpoints were parasitological cure rates on days 14 and 28.results Both regimens were well tolerated; no child was withdrawn because of drug intolerance. Fever (1.9 ± 1.1 vs. 2.4 ± 1.2 days, P ¼ 0.02) and parasite clearance (2.3 ± 0.9 vs. 2.7 ± 1.1 days, P ¼ 0.04) were significantly shorter, and the parasitological cure rate on day 14 (96.2% vs. 83.5%, P ¼ 0.02) but not day 28 (79.4% vs. 72.6%, P ¼ 0.4), was significantly higher in children treated with pyrimethamine-sulphadoxine-probenecid than in those treated with pyrimethamine-sulphadoxine. Gametocyte carriage was similar with both treatment regimens.conclusions The combination of pyrimethamine-sulphadoxine, and probenecid, at a relatively moderate dose, improved treatment efficacy but had no effect on gametocyte carriage. The pyrimethamine-sulphadoxine-probenecid combination merits further evaluation as a potential treatment for use in Nigeria.

show abstract

Section: Study Areamentioning

confidence: 99%

Open randomized study of pyrimethamine–sulphadoxine vs. pyrimethamine–sulphadoxine plus probenecid for the treatment of uncomplicated Plasmodium falciparum malaria in children

Sowunmi

Fehintola

Adedeji

et al. 2004

Tropical Med Int Health

Self Cite

View full text Add to dashboard Cite

show abstract

“…Two studies indicate that the SP clears parasites within 48-72 h. 128 In Malawi, Schultz and colleagues 129 demonstrated that two curative doses of SP (one in the second trimester and a second in the third trimester) significantly reduced placental parasitaemia. WHO currently recommends intermittent preventive treatment in pregnancy (IPTp) with SP, with two curative doses 1 month apart from the second trimester of pregnancy, the first dose being given between weeks 14 and 20 and the second at least 1 month after the first.…”

Section: Introductionmentioning

confidence: 99%

A brief review on features of falciparum malaria during pregnancy

Manirakiza

Serdouma

Ngbale

et al. 2017

J Public Health Afr

View full text Add to dashboard Cite

Malaria in pregnancy is a serious public health problem in tropical areas. Frequently, the placenta is infected by accumulation of Plasmodium falciparum-infected erythrocytes in the intervillous space. Falciparum malaria acts during pregnancy by a range of mechanisms, and chronic or repeated infection and co-infections have insidious effects. The susceptibility of pregnant women to malaria is due to both immunological and humoral changes. Until a malaria vaccine becomes available, the deleterious effects of malaria in pregnancy can be avoided by protection against infection and prompt treatment with safe, effective antimalarial agents; however, concurrent infections such as with HIV and helminths during pregnancy are jeopardizing malaria control in sub-Saharan Africa.

show abstract

Efficacy of artemether in severe falciparum malaria in African children

Sowunmi

Oduola

1996

Acta Tropica

View full text Add to dashboard Cite

Intramuscular sulfadoxine-pyrimethamine in uncomplicated chloroquine-resistant falciparum malaria during pregnancy

Cited by 14 publications

References 3 publications

Open randomized study of pyrimethamine–sulphadoxine vs. pyrimethamine–sulphadoxine plus probenecid for the treatment of uncomplicated Plasmodium falciparum malaria in children

Open randomized study of pyrimethamine–sulphadoxine vs. pyrimethamine–sulphadoxine plus probenecid for the treatment of uncomplicated Plasmodium falciparum malaria in children

A brief review on features of falciparum malaria during pregnancy

Efficacy of artemether in severe falciparum malaria in African children

Contact Info

Product

Resources

About