A brief review on features of falciparum malaria during pregnancy

Manirakiza, Alexandre; Serdouma, Eugène; Ngbale, R.; Moussa, Sandrine; Gondje, S; Degana, Rock Mbetid; Bata, G; Moyen, Jean Methode; Delmont, J.; Grésenguet, Gérard; Sépou, A.

doi:10.4081/jphia.2017.668

Cited by 12 publications

(12 citation statements)

References 185 publications

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“…That LLIN use conferred protection from moderate to severe anaemia but not from parasite infection herein may imply that LLINs nevertheless played a role in preventing malaria infection that has gone undetectable and which would have yet resulted in anaemia in this study [ 39 ]. IPT use in pregnancy has been associated with improved anaemia status in this and several other studies in Uganda [ 43 ], Ghana [ 44 – 46 ] and other countries [ 47 ], while administration of IPT was inconsequential in the development of maternal anaemia in other studies [ 48 ]. Herbal remedy users were 33% in this study similar to one-third rate observed in an Ibadan study of determinants of self-medication practices among pregnant women [ 49 ], but less than 67.5% in a study covering three geopolitical regions in Nigeria [ 50 ] and 68% seen in Abeokuta [ 51 ].…”

Section: Discussionsupporting

confidence: 64%

Socio-economic behavioural indicators of falciparum malaria parasitaemia and moderate to severe anaemia among pregnant women attending antenatal clinics in Lagos, Southwest Nigeria

Olukosi

Olakiigbe

Ajibaye

et al. 2020

Malar J

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Background Incidence of malaria and anaemia are of public health importance especially in pregnant women in endemic regions, due to the negative health consequences to the mother and fetus. This study aimed to assess the pattern of falciparum malaria infection and anaemia, based on malaria prevention methods practiced by participants. Methods A semi-structured tool was used to capture information on demographic, socio-economic and malaria prevention practices from 113 pregnant women attending antenatal clinics in 2 peri-urban health facilities in Lagos, southwest Nigeria. Malaria microscopy was conducted and haematocrit was measured. Logistic regression analysis was performed on the data collated from the survey. Results The prevalence of anaemia among pregnant women was 87.2%. The mean (± sd) packed cell volume (PCV) (%) of the 22 (19.5%) infected subjects (26.8 ± 6.6), was significantly lower (t = −2.60, P value = 0.007) than that of the 91 (80.5%) uninfected subjects (30.8 ± 6.0). The prevalence of infection was highest in the 3rd trimester (n = 40, 35.4%) at 27.5% (11/40) and among those in their first pregnancy (n = 32, 28.3%) at 25.0% (8/32). There was a significant difference (t = −2.23, P-value = 0.01) in the mean PCV % of pregnant women who consumed herbal teas in pregnancy (28.2 ± 5.2) compared to those who did not (30.8 ± 6.6). Regression analysis showed that first pregnancy, anti-malarial use and insecticide-treated nets use the night before study had increased odds of malaria infection in participants (OR = 1.35, P = 0.006, 95% CI 0.52−2.49; OR = 2.3, P = 0.005, 95% CI 0.14−0.41; OR = 1.92, P = 0.001, 95% CI 0.62−5.98) while intermittent preventive treatment (IPT) participation and formal education were strongly and significantly associated with lower risk of parasitaemia (OR = 0.95, P = 0.025, 95% CI 0.41−2.26; OR = 0.44, P = 0.005, 95% CI 0.34−10.50). Conclusion Interventions that will reduce malaria and moderate to severe anaemia, especially in a first pregnancy, should include education on the correct use of long-lasting insecticide-treated bed nets (LLIN), IPT and the dangers of herbal teas in pregnancy.

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Section: Discussionsupporting

confidence: 64%

Socio-economic behavioural indicators of falciparum malaria parasitaemia and moderate to severe anaemia among pregnant women attending antenatal clinics in Lagos, Southwest Nigeria

Olukosi

Olakiigbe

Ajibaye

et al. 2020

Malar J

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“…These alterations provide a possible explanation for the disruption of pregnancy . Other infection models, such as malaria during pregnancy, indicate that macrophage accumulation in the placenta is a key determinant in the immune pathology associated with this parasite…”

Section: Decidual Immune Cells and T Gondii Infectionmentioning

confidence: 98%

How does toxoplasmosis affect the maternal‐foetal immune interface and pregnancy?

Borges

Silva

Brito

et al. 2018

Parasite Immunology

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Toxoplasma gondii is a zoonotic parasite which, depending on the geographical location, can infect between 10% and 90% of humans. Infection during pregnancy may result in congenital toxoplasmosis. The effects on the foetus vary depending on the stage of gestation in which primary maternal infection arises. A large body of research has focused on understanding immune response to toxoplasmosis, although few studies have addressed how it is affected by pregnancy or the pathological consequences of infection at the maternal-foetal interface. There is a lack of knowledge about how maternal immune cells, specifically macrophages, are modulated during infection and the resulting consequences for parasite control and pathology. Herein, we discuss the potential of T. gondii infection to affect the maternal-foetal interface and the potential of pregnancy to disrupt maternal immunity to T. gondii infection. K E Y W O R D Sactivated-macrophage, congenital toxoplasmosis, immunopathogenesis, maternal-foetal Interface, pregnancy, zoonosis

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“…8,9 All pregnant women are not equally susceptible to malaria; the susceptibility and severity of pregnant women to malaria is attributable to varying factors which include immunological and humoral changes, parity, maternal age, gestational age and intensity of transmission. 10 Malaria in pregnancy often leads to clinical complications with attendant effects such as low birth weight, abortion, premature delivery and maternal death. 8,11,12 Malaria in pregnancy is responsible for 5% of maternal anemia and 11% of maternal mortality in Nigeria.…”

Section: Analyses Of Case-based Surveillance Data On Malaria In Pregnancy In Plateau State Nigeria 2013-2017mentioning

confidence: 99%

Analyses of case-based surveillance data on malaria in pregnancy in Plateau State, Nigeria 2013–2017

Iyare

Adebowale

Umeokonkwo

et al. 2020

Proceedings of Singapore Healthcare

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Background: Malaria in pregnancy accounts for 11% of maternal death in Nigeria. Plateau State has a low uptake of intermittent preventive treatment of malaria among women attending antenatal care. Objectives: This study examined the trend and made projections of reported cases of malaria in pregnancy in Plateau State. Methods: Data were extracted from the state disease surveillance system from January 2013 to December 2017. Reported cases of malaria in pregnancy within the 5 years under investigation were retrieved, merged and sorted by month of reporting and Local Government Area (LGA). Prevalence was calculated yearly for each LGA in Plateau State using Geographic Information System. Seasonal variation and projection were based on a multiplicative time series model. Results: In total, 62,997 cases of malaria in pregnancy were retrieved. Prevalence was 6.9% in 2013 and increased to 15.1% in 2017. Higher prevalence was observed in Wase, Kanam and Shendam LGAs. A cyclical trend with highest number of malaria in pregnancy cases was found within the third quarter of all the years. Within the 5 years, there was higher seasonal variation for quarters three (1.209834) and one (1.099711). The highest number of cases of malaria in pregnancy was likely to occur in the third quarter, while the least was found in the second quarter. The projected numbers of malaria in pregnancy cases are 20,121, 22,593 and 25,064 for year 2018, 2019 and 2020, respectively, and the highest number of cases occurs in the third quarter. Conclusion: Malaria in pregnancy follows an increasing trend in Plateau State, with greatest severity in the third quarter of the year. An effective intervention strategy against malaria among pregnant women is advocated.

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A brief review on features of falciparum malaria during pregnancy

Cited by 12 publications

References 185 publications

Socio-economic behavioural indicators of falciparum malaria parasitaemia and moderate to severe anaemia among pregnant women attending antenatal clinics in Lagos, Southwest Nigeria

Socio-economic behavioural indicators of falciparum malaria parasitaemia and moderate to severe anaemia among pregnant women attending antenatal clinics in Lagos, Southwest Nigeria

How does toxoplasmosis affect the maternal‐foetal immune interface and pregnancy?

Analyses of case-based surveillance data on malaria in pregnancy in Plateau State, Nigeria 2013–2017

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