Intramuscular MAPK signaling following high volume and high intensity resistance exercise protocols in trained men

Gonzalez, Adam M.; Hoffman, Jay R.; Townsend, Jeremy R.; Jajtner, Adam R.; Boone, Carleigh H.; Beyer, Kyle S.; Baker, Kayla M.; Wells, Adam J.; Mangine, Gerald T.; Robinson, Edward H.; Church, David D.; Oliveira, Leonardo P.; Fukuda, David H.; Stout, Jeffrey R.

doi:10.1007/s00421-016-3417-8

Cited by 16 publications

(22 citation statements)

References 40 publications

(49 reference statements)

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“…In this study, JNK was significantly increased compared to the control at 1H in both exercise groups, and only PL was elevated at 5H compared to the control group. These findings are largely in support of previous research regarding eccentric and dynamic resistance exercise (Aronson et al 1998;Boppart et al 1999;Galpin et al 2011;Gonzalez et al 2016). A previous investigation reported increased intramuscular JNK phosphorylation at 1H postexercise in resistance trained males following two separate resistance exercise protocols in resistance trained males (Gonzalez et al 2016).…”

Section: Discussionsupporting

confidence: 89%

“…A previous investigation reported increased intramuscular JNK phosphorylation at 1H postexercise in resistance trained males following two separate resistance exercise protocols in resistance trained males (Gonzalez et al. ). In addition, substantial increases in JNK phosphorylation have been described during (148%) and immediately following (141%) a high intensity, power‐lifting resistance protocol (Galpin et al.…”

Section: Discussionmentioning

confidence: 94%

“…; Gonzalez et al. ). A previous investigation reported increased intramuscular JNK phosphorylation at 1H postexercise in resistance trained males following two separate resistance exercise protocols in resistance trained males (Gonzalez et al.…”

Section: Discussionmentioning

confidence: 98%

“…; Gonzalez et al. ). At 5H postexercise, PPB appears to have attenuated intramuscular JNK phosphorylation while PL was still significantly elevated.…”

Section: Discussionmentioning

confidence: 98%

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Polyphenol supplementation alters intramuscular apoptotic signaling following acute resistance exercise

et al. 2018

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The purpose of this study was to examine the effects of 28‐days of supplementation with an aqueous proprietary polyphenol blend (PPB) sourced from Camellia sinensis on intramuscular apoptotic signaling following an acute lower‐body resistance exercise protocol and subsequent recovery. Untrained males (n = 38, 21.8 ± 2.7 years, 173.4 ± 7.9 cm, 77.6 ± 14.6 kg) were randomized to PPB (n = 14), placebo (PL; n = 14) or control (CON; n = 10). Participants completed a lower‐body resistance exercise protocol comprised of the squat, leg press, and leg extension exercises. Skeletal muscle microbiopsies were obtained from the vastus lateralis preexercise (PRE), 1‐h (1HR), 5‐h (5HR), and 48‐h (48HR) post‐resistance exercise. Apoptotic signaling pathways were quantified using multiplex signaling assay kits to quantify total proteins (Caspase 3, 8, 9) and markers of phosphorylation status (JNK, FADD, p53, BAD, Bcl‐2). Changes in markers of muscle damage and intramuscular signaling were analyzed via separate repeated measures analysis of variance (ANOVA). Change in Bcl‐2 phosphorylation at 1H was significantly greater in PL compared to CON (P = 0.001). BAD phosphorylation was significantly elevated at 5H in PL compared to PPB (P = 0.015) and CON (P = 0.006). The change in JNK phosphorylation was significantly greater in PPB (P = 0.009), and PL (P = 0.017) compared to CON at 1H, while the change for PL was elevated compared to CON at 5H (P = 0.002). A main effect was observed (P < 0.05) at 1H, 5H, and 48H for p53 and Caspase 8, with Caspase 3 and Caspase 9 elevated at 48H. These data indicate that chronic supplementation with PPB alters apoptotic signaling in skeletal muscle following acute muscle‐damaging resistance exercise.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 98%

“…; Gonzalez et al. ). At 5H postexercise, PPB appears to have attenuated intramuscular JNK phosphorylation while PL was still significantly elevated.…”

Section: Discussionmentioning

confidence: 98%

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Polyphenol supplementation alters intramuscular apoptotic signaling following acute resistance exercise

et al. 2018

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“…In most physiological circumstances, IL‐6 is a pro‐inflammatory adipokine, which is abundantly secreted by PVAT, compared with retroperitoneal and subcutaneous fat (Gonzalez et al ., ). IL‐6 is a mediator of inflammation and therefore related to AT dysfunction (Bays et al ., 2009).…”

Section: Local Control Of Exercise On At: Myokinesmentioning

confidence: 97%

Exercise effects on perivascular adipose tissue: endocrine and paracrine determinants of vascular function

Boa

Yudkin

Hinsbergh

et al. 2017

British J Pharmacology

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Obesity is a global epidemic, accompanied by increased risk of type 2 diabetes and cardiovascular disease. Adipose tissue hypertrophy is associated with adipose tissue inflammation, which alters the secretion of adipose tissue‐derived bioactive products, known as adipokines. Adipokines determine vessel wall properties such as smooth muscle tone and vessel wall inflammation. Exercise is a mainstay of prevention of chronic, non‐communicable diseases, type 2 diabetes and cardiovascular disease in particular. Aside from reducing adipose tissue mass, exercise has been shown to reduce inflammatory activity in this tissue. Mechanistically, contracting muscles release bioactive molecules known as myokines, which alter the metabolic phenotype of adipose tissue. In adipose tissue, myokines induce browning, enhance fatty acid oxidation and improve insulin sensitivity. In the past years, the perivascular adipose tissue (PVAT) which surrounds the vasculature, has been shown to control vascular tone and inflammation through local release of adipokines. In obesity, an increase in mass and inflammation of PVAT culminate in dysregulation of adipokine secretion, which contributes to vascular dysfunction. This review describes our current understanding of the mechanisms by which active muscles interact with adipose tissue and improve vascular function. Aside from the exercise‐dependent regulation of canonical adipose tissue function, we will focus on the interactions between skeletal muscle and PVAT and the role of novel myokines, such as IL‐15, FGF21 and irisin, in these interactions. Linked Articles This article is part of a themed section on Molecular Mechanisms Regulating Perivascular Adipose Tissue – Potential Pharmacological Targets? To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v174.20/issuetoc

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MAPK, androgen, and glucocorticoid receptor phosphorylation following high-frequency resistance exercise non-functional overreaching

et al. 2019

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Intramuscular MAPK signaling following high volume and high intensity resistance exercise protocols in trained men

Abstract: HV and HI lower body resistance exercise protocols appear to elicit similar MAPK activation in resistance-trained men.

Cited by 16 publications

References 40 publications

Polyphenol supplementation alters intramuscular apoptotic signaling following acute resistance exercise

Polyphenol supplementation alters intramuscular apoptotic signaling following acute resistance exercise

Exercise effects on perivascular adipose tissue: endocrine and paracrine determinants of vascular function

MAPK, androgen, and glucocorticoid receptor phosphorylation following high-frequency resistance exercise non-functional overreaching

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