Intramural Metastasis as a Risk Factor for Recurrence in Esophageal Squamous Cell Carcinoma

Moon, Deok‐Bog; Jeon, Jae Hyun; Yang, Hee Chul; Kim, Young Il; Lee, Jong Yeul; Kim, Moon Soo; Lee, Jong Mog; Lee, Geon Kook

doi:10.1016/j.athoracsur.2018.02.018

Cited by 21 publications

(30 citation statements)

References 24 publications

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“…Zhang et al 29 discovered that higher T stage, higher N stage, and poor tumor differentiation grade were positively related to bone metastases in initial bladder cancer. Similar conclusion was drawn in the study conducted by Moon 30 . In patients with DM, multivariate Cox analysis showed that tumor grade, age at diagnosis, T stage, N stage, marital status, and the administration of surgery was a prognostic factor for OS.…”

Section: Discussionsupporting

confidence: 87%

“…Similar conclusion was drawn in the study conducted by Moon. 30 In patients with DM, multivariate Cox analysis showed that tumor grade, age at diagnosis, T stage, N stage, marital status, and the administration of surgery was a prognostic factor for OS. Many previous studies have found that age at diagnosis, T stage, N stage, and tumor differentiation played important roles in cancer survival outcomes.…”

Section: Discussionmentioning

confidence: 99%

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Patterns of distant metastases in patients with clear cell renal cell carcinoma––A population‐based analysis

Xue

Chen

et al. 2020

Cancer Medicine

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We developed this study to describe the patterns of distant metastasis (DM) and explore the predictive and prognostic factors of DM in clear cell renal cell carcinoma (ccRCC) patients. We collected the eligible patients from the Surveillance, Epidemiology, and End Result (SEER) database from 2010 to 2015. Then, comparisons of baseline characteristics between patients in different metastatic patterns were made. In addition, proportional mortality ratios (PMRs) and proportion trends of different patterns were calculated. Afterward, survival outcomes were explored by Kaplan–Meier (KM) analyses. Finally, predictive and prognostic factors of DM were investigated. A total of 33,449 ccRCC patients were eventually identified, including 2931 patients with DM and 30,518 patients without DM. 8.76% of patients suffered DM at their initial diagnosis, 35.01% of them had multiple metastases. Generally, lung (6.19%) was the most common metastatic site in patients with DM, and brain (1.20%) was the least frequent metastatic organ. The proportion trends of different metastatic patterns tended to be stable between 2010 and 2015. Moreover, higher tumor grade, T stage, and N stage were identified as risk factors of DM. Finally, age at diagnosis, grade, T stage, N stage, the administration of surgery, the number of metastatic sties, marital status, and household income were found to be significantly associated with prognosis. Lung was the most common metastatic site in ccRCC patients. Different survival outcomes and prognostic factors were identified for different metastatic patterns. Hence, our study would have great value for clinical practice in the future.

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Section: Discussionsupporting

confidence: 87%

Section: Discussionmentioning

confidence: 99%

Patterns of distant metastases in patients with clear cell renal cell carcinoma––A population‐based analysis

Xue

Chen

et al. 2020

Cancer Medicine

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“…However, there is a possibility of intramural metastasis from transverse colon cancer to the appendix; therefore, awareness of our rare case of intramural metastasis is important. Intramural metastasis is considered an important factor predicting poor prognosis in esophageal [3,8,9], gastric [2], and rectal [5] cancers. Although there is a lack of consensus regarding treatment strategies, intramural metastasis might also be a poor prognostic factor in metastasis from colon cancer to the appendix.…”

Section: Discussionmentioning

confidence: 99%

Intramural metastasis to the appendix from ascending colon cancer: a case report

et al. 2020

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Background: Intramural metastasis is rare in colorectal cancer, especially metastasis of ascending colon cancer to the appendix. Case presentation: A 64-year-old man was admitted to our hospital for surgery for ascending colon cancer detected by medical examination. Colonoscopy identified a type-2 tumor in the ascending colon, which was diagnosed as adenocarcinoma. Abdominal computed tomography revealed focal thickening of the ascending colon and middle of the appendix and swelling of the lymph nodes around the ileocolic artery. The patient underwent laparoscopic right hemi-colectomy with D3 lymph node dissection. Histopathological findings revealed that the ascending colon cancer was moderately differentiated adenocarcinoma with lymphatic and vascular invasion (stage IIIB; pT3N2M0). Additionally, moderately differentiated adenocarcinoma was observed mainly in the submucosa and muscularis propria of the appendix, which was approximately 10 cm proximal to the ascending colon cancer. These findings indicated intramural metastasis to the appendix from the ascending colon cancer. The patient experienced recurrence with lung metastasis 2.5 years after the first surgery. Conclusions: Intramural metastasis of ascending colon cancer to the appendix is extremely rare. Because the risk of recurrence and the prognosis for intramural metastasis has not been clarified, careful follow-up is recommended.

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“…Recurrence of an esophagogastric anastomotic stricture is more likely to occur <2 years after esophagectomy ( 3 , 18 , 19 ) and it may be related to metastasis to lymph nodes and intramural metastasis of esophageal cancer ( 20 ). Rasihashemi and colleagues ( 21 ) reported that the anastomotic type is related to benign stenosis, but not to recurrent stenosis.…”

Section: Discussionmentioning

confidence: 99%

Arterial Infusion Chemotherapy for Neoplastic Esophagogastric Anastomotic Strictures After Esophagectomy

Xie

Yin

et al. 2021

Front. Oncol.

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BackgroundNeoplastic esophagogastric anastomotic strictures after resection of esophageal cancer is a very difficult problem in clinical practice. We aim at to investigate the safety and feasibility of arterial infusion chemotherapy in treatment of neoplastic esophagogastric anastomotic strictures after esophagectomy.MethodsFrom October 2014 to December 2019, 50 patients with Neoplastic esophagogastric anastomotic strictures after resection of esophageal cancer were assessed retrospectively. Preoperative dysphagia was grade III in 34 cases and grade IV in 16 cases. Thirty-eight patients had different degrees of dyspnea before surgery Twenty-five patients had intolerable (grade IV) dyspnea and airway stenting was undertaken before surgery. Thirteen patients had tolerable dyspnea that did not require airway stenting, and preoperative dyspnea was grade III.ResultsAll patients were successfully treated with arterial infusion chemotherapy, no paraplegia or death occurred. The dysphagia grade of 50 patients after AIC was compared: one case had grade I, 40 cases had grade II, and nine cases had grade III. Thirteen patients had tolerable dyspnea that did not necessitate airway stenting. Dyspnea was classified as grade I in five cases and grade II in eight cases. After 1–3 courses of AIC, 50 patients were followed up for a complete response (eight cases), partial response (28) and stable disease (14 cases). Total objective effective rate (complete response+ partial response) and disease control rate(complete response + partial response + stable disease)were 72.0% and 100.0%, respectively. The median duration of follow-up was 8.5 months. One-year survival was 46.0%.ConclusionArterial infusion chemotherapy is safe and efficacious treatment for Neoplastic esophagogastric anastomotic strictures after esophagectomy.

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Intramural Metastasis as a Risk Factor for Recurrence in Esophageal Squamous Cell Carcinoma

Abstract: IM could be an important prognostic factor, along with anatomic determinants such as the TNM staging system, in patients with ESCC. Effective preoperative evaluation and postoperative surveillance may help improve the outcome of patients with ESCC, particularly when accompanied by IM.

Cited by 21 publications

References 24 publications

Patterns of distant metastases in patients with clear cell renal cell carcinoma––A population‐based analysis

Patterns of distant metastases in patients with clear cell renal cell carcinoma––A population‐based analysis

Intramural metastasis to the appendix from ascending colon cancer: a case report

Arterial Infusion Chemotherapy for Neoplastic Esophagogastric Anastomotic Strictures After Esophagectomy

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