Arterial Infusion Chemotherapy for Neoplastic Esophagogastric Anastomotic Strictures After Esophagectomy

Xie, Pengfei; Yin, Meipan; He, Wei; Ma, Yaozhen; Li, Chunxia; Li, Zhen; Li, Xiaobing; Wang, Shuai; Wu, Gang

doi:10.3389/fonc.2021.668593

Cited by 5 publications

(3 citation statements)

References 40 publications

(48 reference statements)

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“…Reducing the accumulation of acidic products and pH value will lead to a decrease in the healing ability and affect tissue self-repair, thereby increasing the incidence of benign anastomotic stenosis. In this regard, clinical attention should be paid to the preoperative and postoperative blood supply of patients and timely correction of the abnormal situation [ 16 , 17 ]. ③Anastomotic location: studies have shown that the risk of stenosis varies in different anastomotic locations [ 18 ].…”

Section: Discussionmentioning

confidence: 99%

Risk Factors of Benign Stricture of Anastomotic Stoma after Esophagectomy and Therapeutic Effect of Stent Implantation

Guoliang

Niu

Yang

et al. 2022

Emergency Medicine International

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With the increase in the number of patients and prolongation of their lives after esophagectomy for esophageal cancer, the quality of life after surgery has attracted more and more attention. Although anastomotic stenosis is a common complication, it seriously affects the quality of life and psychological state of patients or even threatens their lives. At present, the exact independent influencing factors of anastomotic stenosis after esophageal cancer surgery have not been determined, and relevant treatment options are still controversial. Here, we analyzed the independent risk factors leading to good postoperative anastomotic stenosis, in order to provide a basis for late prevention. At the same time, we deeply discussed the advantages and safety of stent implantation in the treatment of anastomotic stenosis.

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Section: Discussionmentioning

confidence: 99%

Risk Factors of Benign Stricture of Anastomotic Stoma after Esophagectomy and Therapeutic Effect of Stent Implantation

Guoliang

Niu

Yang

et al. 2022

Emergency Medicine International

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“…At present, malignant EAS is managed by placing a nasal feeding tube, a esophageal stent, 3,4 or by tumor-directed treatment. 5 Benign EAS is treated by balloon dilatation (BD). [6][7][8] BD for EAS has varying degrees of complications such as pain, discomfort, esophagogastric anastomotic rupture (EAR), and bleeding that could lead to death in severe cases.…”

Section: Introductionmentioning

confidence: 99%

“…The two types are treated by thoroughly different methods. At present, malignant EAS is managed by placing a nasal feeding tube, a esophageal stent, 3,4 or by tumor‐directed treatment 5 . Benign EAS is treated by balloon dilatation (BD) 6–8 …”

Section: Introductionmentioning

confidence: 99%

Balloon dilatation complications during esophagogastric anastomotic stricture treatment under fluoroscopy: Risk factors, prevention, and management

Wang

Zhang

et al. 2022

Thoracic Cancer

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BackgroundBalloon dilatation (BD) is a common treatment for esophagogastric anastomotic stricture (EAS), but with complications. This study investigates the risk factors, prevention, and management of BD complications to provide clinical guidance.MethodsWe retrospectively analyzed the clinical data of 378 patients with EAS treated by BD from March 2011 to June 2021. The association between esophagogastric anastomotic rupture outcome and patient and stricture characteristics and treatment were analyzed by logistic regression.ResultsBD was performed 552 times and technical success, 98.0%; overall clinical success, 97.8%; major adverse events, 1.3%; minor adverse events, 9.4%; mortality, 0.3%. Logistic regression showed that age (p = 0.080), sex (p = 0.256), interval from surgery to stricture development (p = 0.817), number of dilatations (p = 0.054), cause of stricture (p ≥ 0.168), and preoperative chemotherapy (p = 0.679) were not associated with anastomotic rupture. Balloon diameter (p < 0.001), preoperative radiotherapy (p = 0.003), and chemoradiotherapy (p = 0.021) were correlated with anastomotic rupture. All patients with type I and II ruptures resumed oral feeding without developing into type III rupture. Type III rupture occurred in six cases, who resumed oral feeding after 7–21 days of nasal feeding and liquid feeding. One patient died of massive bleeding after BD.ConclusionsSymptomatic treatment for type I and II ruptures and transnasal decompression and jejunal nutrition tubes for type III rupture, are suggested pending rupture healing. Tumor recurrence, preoperative radiotherapy, and balloon diameter affected the anastomotic rupture outcome.

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Sequential treatment of severe airway stenosis caused by esophageal cancer by using airway stent implantation and arterial infusion chemotherapy

Xie

Wang

et al. 2022

Sci Rep

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The purpose of this clinical study was to investigate the efficacy and safety of airway stent implantation and transarterial infusion chemotherapy in the sequential treatment of severe airway stenosis caused by esophageal cancer. Data of patients with advanced esophageal cancer complicated by severe airway stenosis treated with airway stent implantation and transarterial infusion chemotherapy were retrospectively analyzed. Furthermore, dyspnea, clinical efficacy, adverse reactions, and survival of patients were evaluated. 71 patients were included in this study. There were 28 patients with grade III dyspnea and 43 patients with grade IV dyspnea before airway stent implantation, and 34 patients with grade I dyspnea, 35 patients with grade II dyspnea and 2 patients with grade III dyspnea after airway stent implantation. After airway stent implantation and 1–3 courses of transarterial infusion chemotherapy, 11, 41 and 19 patients had complete response, partial response and stable response respectively. Total disease control rate (DCR) and objective response rate (ORR) were 100.0% and 73.2%, respectively. During the follow-up, 32 patients died of organ failure, 24 patients died of tumor-related respiratory failure, and 10 patients died of gastrointestinal bleeding. The median survival time of all patients was 8 months, and the 1-year survival rate was 40.8%. Airway stent implantation combined with arterial infusion chemotherapy is safe and effective for sequential treatment of esophageal cancer with severe airway stenosis.

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Arterial Infusion Chemotherapy for Neoplastic Esophagogastric Anastomotic Strictures After Esophagectomy

Cited by 5 publications

References 40 publications

Risk Factors of Benign Stricture of Anastomotic Stoma after Esophagectomy and Therapeutic Effect of Stent Implantation

Risk Factors of Benign Stricture of Anastomotic Stoma after Esophagectomy and Therapeutic Effect of Stent Implantation

Balloon dilatation complications during esophagogastric anastomotic stricture treatment under fluoroscopy: Risk factors, prevention, and management

Sequential treatment of severe airway stenosis caused by esophageal cancer by using airway stent implantation and arterial infusion chemotherapy

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