Intramural chondroid hamartoma in the distal esophagus in an adult: A case report and review of the literature

Abstract

Hamartoma of the esophagus is a rare lesion and the number of cases reported in the literature to date is limited. The majority of hamartomas are intraluminal tumors located in the upper third of the esophagus. Histopathologically, the majority of these tumors comprise a mixture of adipose tissue, skeletal/smooth muscle tissue, vascular components and fibrous connective tissue. We herein present the case of a 33-year-old man with an intramural chondroid hamartoma located in the lower third of the esophagus. The patient underwent esophagotomy and the histopathological examination revealed that the tumor was mainly composed of chondroid tissue (60%) admixed with adipose tissue (25%) and fibrous connective tissue (15%). The aim of this study was to describe another variant of esophageal hamartoma, which exhibits a versatile phenotype.

Nonpolypous Hamartomas of the Gastrointestinal Tract: An Updated Review on Classification, Denominations, and Clinical Management

“…It represents <7% of all benign polypoid lesions of the esophagus and are mainly located between muscle and mucosal layer and can be endoscopically resected [ 3 , 50 ]. Differential diagnosis should firstly include low-grade chondrosarcoma, choristoma, and teratoma [ 50 , 51 ].…”

“…Chondromesenchymal, angiomatous, lipomatous, and leiomyomatous hamartomas are other described variants [ 51 ]. Only 19 cases of esophageal hamartomas were reported to date, from which 8 involved the upper segment [ 50 , 51 ].…”

“…Chondromesenchymal, angiomatous, lipomatous, and leiomyomatous hamartomas are other described variants [ 51 ]. Only 19 cases of esophageal hamartomas were reported to date, from which 8 involved the upper segment [ 50 , 51 ]. Leiomyomatosis-like lymphangioleiomyomatosis was reported in three case reports, as a manifestation of tuberous sclerosis in colon and ileocecal segments.…”