Intramolecular chaperone-assisted dual-anchoring activation (ICDA): a suitable preorganization for electrophilic halocyclization

Abstract

Halocyclization reaction represents one of the most common methodologies for the synthesis of heterocyclic molecules. Many efforts have been developed to balance the relationship between structure, reactivity and selectivity, including...

Palladium(ii)-catalyzed intramolecular C–H amination to carbazole: the crucial role of cyclic diacyl peroxides

“…More recently, our group disclosed that the simultaneous use of cyclic diacyl peroxides and halide salts could facilitate the direct generation of heteroatom-centered radicals and electrophilic halocyclization through spatial-confinement non-covalent orientation and intramolecular carboxylate-assisted proximity effects, respectively. 14 All the aforementioned studies indicate that strained cyclic diacyl peroxides and acyclic diacyl peroxides exhibit fundamentally different characteristics, although they share similarities in atom connectivity.…”