Stereocontrolled and time-honored access to piperidine- and pyrrolidine-fused 3-methylenetetrahydropyrans using lactam-tethered alkenols

Abstract

Two cascade approaches featuring bromocycloetherification-elimination or dehydrogenative cycloetherification-isomerization of lactam-tethered alkenols have facilitated the stereocontrolled synthesis of lactam-fused 3-methylenetetrahydropyrans.