Intramedullary spinal cord metastasis associated with pencil-shaped softening of the spinal cord

Hirose, Genjiro; Shimazaki, Kohei; Takado, Matsuhei; Kosoegawa, H; Ohya, Nobuo; Mukawa, A

doi:10.3171/jns.1980.52.5.0718

Cited by 31 publications

(6 citation statements)

References 9 publications

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“…Lung tumours metastasise by arterial dissemination [3,9]. In rare cases, intradural metastases may result from venous dissemination along the so-called Batson's plexus or direct invasion of a dorsal root [3].…”

Section: Disseminationmentioning

confidence: 99%

Intradural and extradural spinal metastases

2001

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Intradural spinal metastases are uncommon. The outcome of surgical treatment of intra- and extramedullary intradural metastases is considered to be poor, with rapid clinical deterioration. The question of optimal treatment remains controversial. We present an overview of the clinical outcome and surgical treatment of 220 spinal metastases carried out in our centre from 1980 to 1999, with particular emphasis on 11 intradural metastases. Clinical history, signs, surgical approach, outcome, and radiological reports were obtained by review of patient charts. Secondary spinal tumours most often originated from carcinomas of the breast, lung, kidney, gastrointestinal tract, and prostate. In 12% of cases, no primary tumour could be found. Drop metastases of intracranial pathology appeared in 3%. Intradural metastases were seen in 11 patients and formed a very heterogeneous group with predominance of melanoma, lymphoma, and medulloblastoma. Functional recovery and survival time were worse in intradural metastases than in extradural metastases, and the patients were younger. Treatment of metastases is designed to relieve pain and preserve or restore neurological function palliatively. Intradural metastases are a devastating condition with usually fatal outcome. Selected patients who undergo aggressive surgical treatment may have substantially increased survival.

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Section: Disseminationmentioning

confidence: 99%

Intradural and extradural spinal metastases

2001

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“…Imaging of the entire spinal canal and brain, preferably with MR, is therefore recommended to aid in diagnosis, prognosis, and treatment, While metastatic disease to the osseous spine with secondary epidural extension and cord compression has often been described, metastases to the spinal cord of nonneurogenic origin have seldom been reported [1 -7]. In contrast to those of CNS origin [8], intramedullary metastases arising from primary tumors outside the CNS are believed to be rare, often found only at autopsy [9][10][11][12][13][14][15][16][17][18][19][20].…”

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confidence: 99%

Intramedullary spinal cord metastases, mainly of nonneurogenic origin

Post

Quencer

Green

et al. 1987

American Journal of Roentgenology

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“…Multiple segments are often affected. Metastatic lesions occur at multiple noncontiguous levels in 10% to 38% of cases [8]. Leptomeningeal and intradural involvement can be found in conjunction with the intramedullary tumor [9] [10].…”

Section: Discussionmentioning

confidence: 99%

Multiple Spinal Intradural-Intramedullary Involvement by Metastatic Carcinoma with Neuroendocrine Differentiation with Occult Primary—An Unusual Case Report and Review of Literature

Gupta¹,

Sinha²

2016

OJPathology

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Although vertebral column is recognized as the most common site for bony metastasis in patient with systemic malignancy, intramedullary metastases to the spinal cord is infrequent. Between 5% -10% of cancer patients develop spinal metastasis during the course of their diseases. Intramedullary tumors are rare, comprising 3.5% of spinal metastasis. Most metastatic spinal lesions (70%) are found at the thoracic level, 20% in lumbar region and 10% in the cervical region. We report a rare biopsy proven case of intramedullary spinal metastatic carcinoma with neuroendocrine differentiation because of its unusual presentation, involving spine at multiple noncontiguous levels, which appeared as irregular small nodules on MRI. The primary tumor was most likely from occult primary in lung. Biopsy from the spinal lesion established the diagnosis of metastatic carcinoma with neuroendocrine differentiation. Therefore, in patients with spinal metastasis, a thorough work up is advised to evaluate primary site. This would help to delineate the nature and the extent of the systemic disease. We highlighted herein the clinical presentation, radiological findings particularly MRI and role of biopsy in the diagnosis and treatment of intramedullary spinal metastasis.

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Intramedullary spinal cord metastasis associated with pencil-shaped softening of the spinal cord

Cited by 31 publications

References 9 publications

Intradural and extradural spinal metastases

Intradural and extradural spinal metastases

Intramedullary spinal cord metastases, mainly of nonneurogenic origin

Multiple Spinal Intradural-Intramedullary Involvement by Metastatic Carcinoma with Neuroendocrine Differentiation with Occult Primary—An Unusual Case Report and Review of Literature

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