Intramedullary spinal cord metastases, mainly of nonneurogenic origin

Post, M. Judith Donovan; Quencer, R M; Green, B. A.; Montalvo, Berta M.; Tobias, J. A.; Sowers, J. J.; Levin, Ilya

doi:10.2214/ajr.148.5.1015

Cited by 36 publications

(19 citation statements)

References 21 publications

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“…22) Myelography and CT myelography generally give negative findings, especially in patients with small lesions which do not alter the contour of the spinal cord. 17,21,26) MR imaging with contrast medium may be the most reliable diagnostic procedure for patients with intramedullary spinal cord metastasis. 9,17,23,26) However, MR imaging without contrast enhancement may not visualize the lesions as in our Case 1.…”

Section: Discussionmentioning

confidence: 99%

Intramedullary Spinal Cord Metastasis: A Rare and Devastating Complication of Cancer -Two Case Reports-

Kaya¹,

Dalkılıç²,

Özer

et al. 2003

Neurol. Med. Chir.(Tokyo)

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Two cases of very rare intramedullary spinal cord metastasis from colon carcinoma and renal carcinoma were treated primarily by microsurgical excision. A 44-year-old female presented with colon carcinoma metastasis manifesting as complete neurological deficit. She had undergone colon resection 2 years previously for colon carcinoma. The tumor was excised by microsurgery with megadose steroid therapy but she remained paraplegic. A 43-year-old man presented with renal carcinoma metastasis manifesting as incomplete neurological deficits. He had undergone nephrectomy one year previously for renal carcinoma. The tumor was removed by microsurgery. He made a remarkable neurological recovery and became ambulatory after physical therapy.

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Section: Discussionmentioning

confidence: 99%

Intramedullary Spinal Cord Metastasis: A Rare and Devastating Complication of Cancer -Two Case Reports-

Kaya¹,

Dalkılıç²,

Özer

et al. 2003

Neurol. Med. Chir.(Tokyo)

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“…*' In human patients, the sensitivity of myelography in the detection of ISCM has been disappointing, with negative myelograms reported in 21 of 50 (42%) patients.14 Newer imaging techniques, such as metrizamide-enhanced computed tomography, magnetic resonance imaging, and intraoperative spinal sonography, have been advocated to improve detection. 22 In human ISCM patients, analysis of CSF cytology seldom reveals malignant cells. 14.…”

Section: Fig 7 Higher Magnification Of Neoplastic Infiltrates Inmentioning

confidence: 99%

Intramedullary Spinal Cord Metastasis in the Dog

Waters

Hayden

1990

Veterinary Internal Medicne

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Intramedullary spinal cord metastasis (ISCM) was diagnosed in three dogs with signs of myelopathy. The clinicopathologic features of ISCM in these and previously reported cases in the veterinary and human literature were compared. Myelopathic signs associated with ISCM may be the initial clinical manifestation of malignancy or may develop in the patient with known malignancy. Pain, a frequent manifestation of extradural compressive myelopathy, is not a consistent feature of ISCM. Survey spinal radiographs are usually unrewarding and cerebrospinal fluid (CSF) abnormalities nonspecific. Myelog‐raphy is indicated to differentiate intramedullary lesions from more common extradural compressive lesions. Myelographic interpretation may be difficult, and intramedullary tumors must be differentiated from spinal cord edema or hemorrhage. Evidence of widely disseminated malignancy should increase suspicion for ISCM; hemangiosarcoma and lymphosarcoma should be considered the most likely histo‐logic types. CSF cytology may be helpful in the diagnosis of patients with lymphosarcoma. Prognosis is poor due to the frequent presence of disseminated disease, although temporary response to corticoste‐roid therapy may be achieved. More aggressive therapeutic approaches, such as spinal irradiation and microsurgical resection of metastases, have been advocated in humans but have not been reported in the dog. Although it is an uncommon complication of systemic malignancy, ISCM should be considered in the differential diagnosis of myelopathy in the dog. (Journal of Veterinary Internal Medicine 1990; 4:207–215)

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“…In patients without history of systemic neoplasia such as the patient in our report, a detailed clinical history and physical examination coupled with selected laboratory and diagnostic imaging investigations may delineate primary or secondary spinal malignant lesions from other more benign differential diagnostic entities. MRI is useful in determining the extent of CNS involvement which may affect the therapeutic decision making in many patients 13,16 . Treatment modalities for ISCM include radiotherapy, surgery, and chemotherapy.…”

Section: Discussionmentioning

confidence: 99%

Renal Cell Carcinoma presented with An Intramedullary Spinal Cord Metastasis : A Case Report

Islam

Rahman²,

Habib

et al. 2016

Bangladesh Crit Care J

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Intramedullary spinal cord metastasis is one of the rare manifestations of systemic neoplasm causing diagnostic dilemma. Here we report a case of metastatic renal cell carcinoma presented initially as spinal cord lesion. A 62 years old Bangladeshi gentleman presented with spastic paraparesis, bone pain with unexplained weight loss. After thorough examination & detailed investigations we found intramedullary spinal cord metastasis with infiltrative lesion on bone scan. We confirmed renal cell carcinoma after doing CT Abdomen and histopathology as primary site of lesion. He was treated by radical nephrectomy & radiotherapy. It is imperative that clinicians should be cautious of occult carcinoma as the cause of suspicious intramedullary spinal cord lesion.Bangladesh Crit Care J March 2016; 4 (1): 51-53

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Intramedullary spinal cord metastases, mainly of nonneurogenic origin

Abstract: These various imaging procedures showed that cord metastases were often more extensive than anticipated clinically. Spread of tumor into the spinal and intracranial subarachnoid space was common.

Cited by 36 publications

References 21 publications

Intramedullary Spinal Cord Metastasis: A Rare and Devastating Complication of Cancer -Two Case Reports-

Intramedullary Spinal Cord Metastasis: A Rare and Devastating Complication of Cancer -Two Case Reports-

Intramedullary Spinal Cord Metastasis in the Dog

Renal Cell Carcinoma presented with An Intramedullary Spinal Cord Metastasis : A Case Report

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