-Solitary bone plasmacytoma of the mandible: a case report and review of literature. Introduction:A solitary plasmacytoma is a malignant tumor characterized by proliferation of monoclonal plasma cells. It preferentially reaches the axial skeleton, in particular the rachis and pelvis. Its location in the jaw is exceptional. Observation: A 49-year-old male patient consulted for a right mandibular tumor which had evolved for six months in an asymptomatic way. After surgical excision performed under general anesthesia in order to establish a diagnosis, histological examination showed that it was a plasmacytoma. The extension work-up confirmed the diagnosis of solitary bone plasmacytoma of the mandible. The patient received adjuvant external radiotherapy. The outcome was favorable. Discussion: From this clinical observation and the review of the literature, the clinical aspect, radiological signs, therapeutic solutions and outcome of this rare disease are discussed. Mandibular location of bone plasmacytoma is very rare and diagnosis is first histological.