Intralobar Pulmonary Sequestration Associated With Marked Elevation of Serum Carbohydrate Antigen 19-9

Ambiru, Satoshi; Nakamura, Shunta; Fukasawa, Motoji; Mishima, Osamu; Kuwahara, Takeichiro; Takeshi, Akihiko

doi:10.1016/j.athoracsur.2009.05.017

Cited by 14 publications

(16 citation statements)

References 5 publications

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“…In the current case, immunohistochemistry demonstrated weak staining of CA19-9 in the normal bronchial epithelia, however, marked staining was identified in the sequestrated lung tissue, particularly in the mucus of the cysts. In the present study, a cyst fluid culture was not performed to exclude possible pathogens; however, the results were generally consistent with the viewpoint of Ambiru et al (12) that CA19-9, which is concentrated in the sequestrated lung, may transfer into the blood through the injured mucosa of the cyst walls. Furthermore, we predict that the diaphragm, stimulated by the consolidated lung, may lead to the left upper abdominal bloating.…”

Section: Discussionsupporting

confidence: 92%

Pulmonary sequestration presenting with left upper abdominal bloating and marked elevation of serum carbohydrate antigen 19-9: A case report

et al. 2014

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Carbohydrate antigen 19-9 (CA19-9) is widely accepted as a tumor marker for cancers of the biliary, pancreatic and gastrointestinal tracts. Occasionally, CA19-9 is markedly elevated in the serum of patients with benign diseases. Pulmonary sequestration is a rare malformation that is characterized by the presence of lung tissue with abnormal or absent communication with the bronchi, to which blood is supplied by the systemic arteries. The current study presents a 48-year-old male who presented with upper left abdominal bloating and marked elevation of serum CA19-9 levels. The patient was referred to the Tongji Hospital (Wuhan, China) with suspected hepato-biliary-pancreatic disease and, following surgery, was diagnosed with intralobar pulmonary sequestration. Immunohistochemistry showed marked positive staining for CA19-9 in the sequestrated lung tissue. The patient’s symptoms improved and the CA19-9 levels returned to the normal range following surgery. Therefore, the symptoms of upper left abdominal bloating and marked elevation of serum CA19-9 levels, in this case, may have resulted from the intralobar pulmonary sequestration.

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Section: Discussionsupporting

confidence: 92%

Pulmonary sequestration presenting with left upper abdominal bloating and marked elevation of serum carbohydrate antigen 19-9: A case report

et al. 2014

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Section: Discussionmentioning

confidence: 81%

“…In intralobar pulmonary sequestration, some cases features with elevated CA19-9 level alone or together with the elevation of other tumor marker such as CEA or CA1255-7, which is also reported in extralobar pulmonary sequestration8. In the cases of elevated CA19-9 in patients with pulmonary sequestration, no abdominal symptoms were found and most cases were accidently identified by blood test for diagnosis of pulmonary sequestration or prior to surgery5-8. Although the exact cause for the condition is not yet, main mechanism is thought to be the effect of chronic inflammatory process of epithelial cells, which is based on the histologic findings of abundancy of mucus, identification of tumor marker response, and no signs for infection in the patients with remarkable elevation of CA19-9 after several years, who had normal level of CA19-9 at the time of initial identification of emphysematous lesion before5.…”

Section: Discussionmentioning

confidence: 99%

“…In the cases of elevated CA19-9 in patients with pulmonary sequestration, no abdominal symptoms were found and most cases were accidently identified by blood test for diagnosis of pulmonary sequestration or prior to surgery5-8. Although the exact cause for the condition is not yet, main mechanism is thought to be the effect of chronic inflammatory process of epithelial cells, which is based on the histologic findings of abundancy of mucus, identification of tumor marker response, and no signs for infection in the patients with remarkable elevation of CA19-9 after several years, who had normal level of CA19-9 at the time of initial identification of emphysematous lesion before5. According to other literature, tumor markers are reported to be synthesized in normal bronchial epithelial cells, and elevated in the blood by productive process of epithelial cells and accumulation in the pulmonary sequestration9.…”

Section: Discussionmentioning

confidence: 99%

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Intralobar Pulmonary Sequestration Showing Increased Serum CA19-9

Ahn¹,

Song²,

Park³

2012

Tuberc Respir Dis

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Carbohydrate antigen 19-9 (CA19-9) is a specific tumor marker of the biliary, pancreatic and gastrointestinal tracts. CA19-9 is occasionally elevated in serum in patiens with benign pulmonary diseases such as bronchiectasis, idiopathic interstitial pneumonia or collagen disease-associated pulmonary fibrosis. Intralobar pulmonary sequestration is an uncommon congenital lung anomaly. It is dissociated from the normal tracheobronchial tree and is supplied by an anomalous systemic artery. There have been some reports of elevation of CA19-9 in this lesion. We report a case of intralobar pulmonary sequestration with elevated serum CA19-9 in a 29-year-old man who was diagnosed with bronchiectasia of left lower lung field on general check up. He had no evidence of any malignant disease in pancreatobiliary or gastrointestinal tracts. Elevated serum CA19-9 level might be encountered with benign pulmonary disease such as pulmonary sequestration.

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“…Some reports showed that the CA19-9 is also produced by the bronchiolar epithelia, as a result of airway damage; it can be elevated in serum (3). Bronchial mucus contains large amounts of CA19-9, which appears to be produced in the columnar epithelia of respiratory glands, even if A B C the serum CA19-9 level are normal (4).…”

Section: Discussionmentioning

confidence: 99%

Pulmonary sequestration associated with significant elevation of serum carbohydrate antigen 19-9: report of two cases

et al. 2016

Ann. Transl. Med.

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This report presents two young women were admitted to the department of thoracic surgery, Beijng Chao-Yang Hospital because of the extremely elevation of the serum Carbohydrate antigen 19-9 (CA19-9). The enhanced Computed Tomography scan showed that the lesion of the lung and the anomalous artery, and diagnosis of the pulmonary sequestration was made. The positron emission tomography/computed tomography (PET/CT) scan was taken to exclude any kind of malignant tumor. Both of them had the lobectomy operation confirmed our preoperative diagnosis. After the operation, the serum level of CA19-9 decreased to normal range rapidly.Therefore, in these two cases, the markedly elevation of serum CA19-9 level may have resulted from the pulmonary sequestration.

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Intralobar Pulmonary Sequestration Associated With Marked Elevation of Serum Carbohydrate Antigen 19-9

Cited by 14 publications

References 5 publications

Pulmonary sequestration presenting with left upper abdominal bloating and marked elevation of serum carbohydrate antigen 19-9: A case report

Pulmonary sequestration presenting with left upper abdominal bloating and marked elevation of serum carbohydrate antigen 19-9: A case report

Intralobar Pulmonary Sequestration Showing Increased Serum CA19-9

Pulmonary sequestration associated with significant elevation of serum carbohydrate antigen 19-9: report of two cases

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