Pulmonary sequestration presenting with left upper abdominal bloating and marked elevation of serum carbohydrate antigen 19-9: A case report

Han, Ping; Luo, Yi; Tian, Dean; Yan, Wei; Liu, Jingmei; Chang, Ying; Xie, Hai; Wang, Wei; Huang, Huanjun

doi:10.3892/ol.2014.1960

Cited by 5 publications

(3 citation statements)

References 12 publications

(7 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Many studies show that pulmonary sequestration with elevated CA19-9 is common in adults and intralobar type. CA19-9 was positive in bronchial mucosal epithelium and alveolar epithelium in the area of immunohistochemical lesion ( 7 , 9 - 13 ). It was speculated that pulmonary sequestration lesions, especially complicated with aspergillus or other pathogenic infection, promoted bronchial epithelial cells to synthesize and secrete CA19-9 ( 14 ), gathered in the dilated bronchial sac cavity, and entered into the blood through the damaged mucosa of the cyst wall ( 15 ).…”

Section: Discussionmentioning

confidence: 97%

Intralobar pulmonary sequestration with aspergillus infection and elevated serum CA19-9 and CA242: a case report

Li¹,

Wang²,

Liu³

et al. 2021

Transl Cancer Res TCR

View full text Add to dashboard Cite

Pulmonary sequestration is a rare congenital dysplasia, and intralobar pulmonary sequestration was caused by aspergillus infection are more uncommon. The significant increase of serum CA19-9 and CA242 often indicates malignant tumors of the pancreas, biliary tract and gastrointestinal tract, but it is different in this case we reported. We present a case of a 36-year-old woman with intralobar pulmonary sequestration with aspergillus infection and elevated serum tumor markers CA19-9 and CA242. The patient had a right lung occupying lesion on the chest CT and sulfur particles are formed in the lesioned bronchial lumen. According to the results of the imaging and pathological, and serum CA19-9 and CA242 increased significantly, it was initially suspected to be a malignant tumor, so the right lobectomy and lymph node dissection were performed. Postoperative pathological examination confirmed intralobar pulmonary sequestration with aspergillus infection. After 22 days of surgery, the level of serum CA19-9 and CA242 were significantly decreased and gradually decreased to normal. This is a rare case of pulmonary sequestration accompanied by aspergillus infection in which serum CA19-9 and CA242 are elevated; it’s also the first report that pulmonary sequestration accompanied by aspergillus infection with sulfur particles formation. It is suggested that patients with pulmonary sequestration, especially those complicated with aspergillus infection, may be accompanied by elevated serum tumor markers CA19-9 and CA242, which should not be misdiagnosed as malignant tumors.

show abstract

Section: Discussionmentioning

confidence: 97%

Intralobar pulmonary sequestration with aspergillus infection and elevated serum CA19-9 and CA242: a case report

Li¹,

Wang²,

Liu³

et al. 2021

Transl Cancer Res TCR

View full text Add to dashboard Cite

show abstract

“…CA 19-9 level is also elevated when the pathway discharging CA 19-9 is obstructed by duct stenosis or stones. Additionally, chronic hepatitis and chronic kidney disease can increase serum CA 19-9 level by hindring CA 19-9 metabolism [2]. CA 19-9 secreted by the bronchiolar epithelia may appear in the serum as a result of airway damage in the lower respiratory tract, such as pulmonary sequestration.…”

Section: Discussionmentioning

confidence: 99%

Elevated Carbohydrate Antigen 19-9 Level in a Patient with Horseshoe Type Pulmonary Sequestration

Park

Cho

2016

Korean J Thorac Cardiovasc Surg

View full text Add to dashboard Cite

Elevated carbohydrate antigen (CA) 19-9 can indicate malignancies of the gastrointestinal, pancreatic, and biliary tracts, and be found in a pulmonary sequestration. A 30-year-old man visited Seoul National University Bundang Hospital due to elevated CA 19-9 levels, representing pulmonary sequestration of the bilateral lower lobes, which were connected with each other. We performed left lower lobectomy and division of the systemic arteries. After operation, CA 19-9 levels decreased to normal range, even though a small amount of sequestrated lung remained in the right lower lobe. It is not uncommon that presence of pulmonary sequestration might elevate serum CA 19-9 levels; however, horseshoe type bilateral pulmonary sequestration is very rare.

show abstract

“…Pulmonary sequestration accounts for 0.15-6.4% of all congenital pulmonary malformations and receives its blood supply from a systemic artery rather than the pulmonary arterial branch [1][2][3][4][5]. The predominant clinical symptoms of pulmonary sequestration consist of coughing (50%), fever (25%), hemoptysis (22.7%), expectoration (18.2%), chest tightness (15.9%) and thoracic pain (11.4%) [6]. Diagnosis is mainly based on chest CT to find local focal opacity, especially in the left lung (Fig.…”

Section: Introductionmentioning

confidence: 99%

Elevated tumor markers in a benign lung disease

Chen

Fei

et al. 2021

J Cardiothorac Surg

View full text Add to dashboard Cite

Background This study aimed to determine the underlying pathophysiologic mechanism of elevated carbohydrate antigen 19-9 (CA19-9) in pulmonary sequestration (PS) patients. Materials and methods Four pulmonary sequestration patients, 12 pneumonia patients and 12 healthy adult volunteers were prospectively studied. Specimens from another 34 pulmonary sequestration patients were retrospectively analyzed. Serum CA19-9 levels of 4 patients were tested before and 1 week, 1 month and 3 months after surgery. The CA19-9 levels of 12 pneumonia patients and 12 healthy adult volunteers were tested as controls. The expression and localization of CA19-9 in diseased lesions and corresponding normal lung tissues were analyzed by Immunohistochemical (IHC). Hematoxylin–eosin (HE) staining was performed to observe the pathological changes in pulmonary sequestration tissues. Results Serum CA19-9 levels were significantly higher in the 4 patients (797.3 ± 316 IU/ml) than in the pneumonia patients (10.07 ± 5.01 IU/ml) and healthy volunteers (9.85 ± 4.12 IU/ml). In addition, serum CA19-9 levels decreased dramatically after the focus was removed. Positive staining of CA19-9 was found in 70% (24/34) of pulmonary sequestration tissues, and CA19-9 was mainly expressed in the bronchial mucus. In the 4 diseased lesions, deformed alveolar structure and inflammatory cell infiltration were observed, and the degree of damage was positively correlated with serum CA19-9 levels. Conclusions CA19-9 could be generated by abnormal columnar epithelia in pulmonary sequestration tissues and was transported into circulation after alveoli damage. CA19-9 could serve as an adjuvant diagnostic marker in pulmonary sequestration.

show abstract

Pulmonary sequestration presenting with left upper abdominal bloating and marked elevation of serum carbohydrate antigen 19-9: A case report

Cited by 5 publications

References 12 publications

Intralobar pulmonary sequestration with aspergillus infection and elevated serum CA19-9 and CA242: a case report

Intralobar pulmonary sequestration with aspergillus infection and elevated serum CA19-9 and CA242: a case report

Elevated Carbohydrate Antigen 19-9 Level in a Patient with Horseshoe Type Pulmonary Sequestration

Elevated tumor markers in a benign lung disease

Contact Info

Product

Resources

About