Intralesional Triamcinolone Acetonide for Keloid Treatment: A Systematic Review

Hochman, Bernardo; Locali, Rafael Fagionato; Matsuoka, Priscila Katsumi; Ferreira, Lydia Masako

doi:10.1007/s00266-008-9152-8

Cited by 63 publications

(44 citation statements)

References 16 publications

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“…In the researched literature, the studies found, concerning blue spectrum, reported the inhibition of cell proliferation or no change in fibroblasts 17 . In addition, this wavelength also exerts an inhibitory effect on acne 9 , characterized by neurogenic inflammation, which is exacerbated in keloid 5 . In vitro studies with LASER or LED often use well plates, in which one well is next to the other, eventually dissipating energy to each other.…”

Section: Discussionmentioning

confidence: 99%

“…The literature presents many options of treatment, alone or in combination, nevertheless they are not specific. Among the therapeutic modalities that have been most used, stand out the administration of topical and intralesional corticosteroids, the use of silicon plates, pressotherapy and exeresis followed by betatherapy 4,5 . Recently, high potency LASER (Light Amplification by Stimulated Emission of Radiation) and IPL (Intense Pulsed Light) were added to that arsenal.…”

Section: Introductionmentioning

confidence: 99%

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In vitro effect of 470 nm LED (Light Emitting Diode) in keloid fibroblasts

et al. 2011

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Purpose:To quantify keloid fibroblasts after irradiation with 470nm blue LED, in vitro. Methods: Fibroblasts from keloid and adjacent skin have been obtained from 6 patients. Cells have been cultivated and maintained in DMEM culture medium. In Petri dishes, they were irradiated with energy doses of 6J, 12J and 18J. After 24 h, counting was done by the average of the triplicates for each sample. Results: There were no significant differences in the number of irradiated keloid fibroblasts at the studied doses (p=0.261). In adjacent skin fibroblasts, differences were observed (p=0.025) concerning the doses of 18 J and 6 J (p=0.03). Conclusions: There was a reduction in the number of adjacent skin fibroblasts irradiated with 470nm blue LED at the energy dose of 18 J compared to the ones irradiated at the energy dose of 6 J. There were no changes in keloid fibroblasts counting at any of the doses applied, 24 h after irradiation. Key words: Fibroblasts. Keloid. Phototherapy. Lasers. Skin. Laser Therapy, Low-Level. RESUMOObjetivo: Quantificar fibroblastos de quelóide após irradiação com LED azul de 470nm, in vitro. Métodos: Foram obtidos fibroblastos de quelóide e pele adjacente, de seis pacientes. As células foram cultivadas e mantidas em meio de cultura DMEM. Em placas de Petri, receberam irradiação com doses de energia de 6J, 12J e 18J. Após 24 horas a contagem foi feita pela média da triplicata para cada amostra. Resultados: Não houve diferença na quantidade de fibroblastos de quelóide irradiados nas doses estudadas (p=0,261). Observou-se diferença nos fibroblastos de pele adjacente (p=0,025), com relação às doses de 18 J e 6 J (p=0,03). Conclusões: Houve redução dos fibroblastos de pele adjacente irradiados com LED azul de 470 nm na dose de energia de 18 J em relação à dose de 6 J. Não houve alteração na quantidade de fibroblastos de quelóide nas doses aplicadas após 24 horas da irradiação.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

In vitro effect of 470 nm LED (Light Emitting Diode) in keloid fibroblasts

et al. 2011

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“…Further studies will be needed to ascertain or complement this despite the generally known fact that lower animals do not form keloids The wounds treated with triamcinolone also showed significant reduction in the thickness and quantity of collagen fibres. Triamcinolone is indicated in the treatment of keloids [Hochman et al,2008]. While the exact mechanisms of action of steroids, such as triamcinolone, in the treatment of keloids are still unclear, their anti-keloidal activities most likely result from suppression of the inflammatory response and from diminished collagen synthesis, inhibition of fibroblast growth and enhanced collagen degeneration [Wu Ws et al,2006].…”

Section: Discussionmentioning

confidence: 99%

Wound-healing and potential anti-keloidal properties of the latex of <i>Calotropis procera</i> (aiton) asclepiadaceae in rabbits

Aderounmua¹,

Omonisib²,

Akingbasotec³

et al. 2013

Afr. J. Trad. Compl. Alt. Med.

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Calotropis Procera (CP) has been used in the management of toothache, fresh skin burns, gum bleeding as well as others to make it qualify as a medicinal plant. This study was designed to assess its wound-healing property in rabbits and its potentials for anti keloidal activity.Fresh latex of Calotropis were obtained and evaluated phytochemically. Fifteen male rabbits were used and four excisional wounds were created on each rabbit. The rabbits were divided into five groups of three each. Group 1 was the negative control and received no treatment. The wounds of group 2 animals were treated with 2mL of Calotropis latex; group 3 with 2mL honey; and group 4 with a mixture of 1ml honey and 1 mL of the latex. The animals in group 5 were given 2mg triamcinolone intramuscularly. All the groups had their wounds treated daily for 21 days. The wounds' diameters were measured on the day of wound creation, thereafter on days 7, 14 and 21 post wound creation. Biopsies of the wounds were taken on days 3 and 21 and viewed histologically. Phytochemical study of the latex revealed the presence of glycosides, tannins and alkaloids. The wounds were found to be significantly (p<0.05) reduced in groups treated with 50% latex in honey and triamcinolone, respectively, on day 7 post wound creation while there was a significant (p<0.05) reduction in wound surface area in all treated groups on days 14 and 21 post wound creation. Histological findings in untreated group showed thick bundle of collagen fibres some of which had broad based configurations, reminiscent of keloid. The group treated with 2mL of Calotropis latex revealed the presence of florid granulation tissues on day 3 while there was a marked reduction in quantity and size of collagen fibres on day 21 post wound creation which was comparable with what was seen for the triamcinolone-treated group.The general effect of Calotropis latex on wound-healing was noted. Likewise it's similarity to that of triamcinolone, an anti-keloidal agent; this makes it a probable candidate for future anti-keloidal study using a suitable model.

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“…Гормонотерапия келоидных и гипертрофических рубцов, а именно назначение кортикотропина и стерои-дов коркового слоя надпочечников (кортизона, гидрокор-тизона, кортизола), получила широкое распространение [73,77,98]. Наиболее эффективной она была после хирур-гического лечения [97].…”

Section: хирургия 9 2015unclassified