Intralesional Interferon Gamma Treatment for Keloids and Hypertrophic Scars

Treatment of Peyronie's Disease with Local lnterferon-a2b

“…The myofibroblasts' proliferation was slowed, and the unde sired effects of INF-y -i.e., increased fibronectin and glycosamioglycan production -did not occur. In humans, intralesional recombinant INF-y has been used with some success in the treatment of keloidal scarring and hypertro phic scars [26,27]. The response rate was 30-50% in about half the patients treated, a finding roughly compa rable with ours.…”

Long-Term Results of Intralesional Triamcinolone Acetonide Injections in Keloid Treatment

“…Previous authors have not investigated the size of the keloid when reporting recurrence rates. Larrabee et al estimate that roughly 50% of keloids might be "cortisone resistant" [20]. It is reasonable to assume, that the recurring, larger keloids had grown faster and were thus more aggressive than the minor keloids that responded well to treatment.…”

“…It has been stated, that some keloids do not respond to TAC injections, these cases are considered steroid resistant [19,20]. There is no consensus or clear indicator to detect steroid sensitive cases [19].…”

Local lnterferon-Alpha2b Is Not an Effective Treatment in Early-Stage Peyronie's Disease

“…The myofibroblasts' proliferation was slowed, and the unde sired effects of IFN-y -i.e. increased fibronectin and glycosaminoglycan production -did not occur [14], In humans, intralesional recombinant IFN-y and IFNa2b has been used to treat keloidal scarring and hypertro phic scars; follow-up biopsies showed a persistent normal ization of keloidal fibroblast collagen, glycosaminoglycan and collagenase production [29,30],…”