Intralesional injection of Pingyangmycin for vascular malformations in oral and maxillofacial regions: An evaluation of 297 consecutive patients

Zheng, Jia Wei; Yang, Xiu Juan; Wang, Yan An; He, Yue; W, Ye; Zhang, Zhi Yuan

doi:10.1016/j.oraloncology.2009.02.011

Cited by 73 publications

(58 citation statements)

References 15 publications

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“…Small VnM's can be completely excised. However, complete surgical eradication of extensive oral or facial venous malformation is rarely possible without jeopardizing function or causing additional disfigurement [9] and/or severe hemorrhage [16]. Other modalities of treatments includes the use of Nd:YAG laser therapy.…”

Section: Discussionmentioning

confidence: 99%

The Use of Sodium Tetradecyl Sulphate for the Treatment of Venous Malformations of the Head and Neck

Alakailly

Kummoona

Quereshy

et al. 2014

J. Maxillofac. Oral Surg.

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Introduction Vascular malformations have devastating cosmetic effects in addition to being associated with pain and bleeding. Sclerotherapy has been used as an effective therapeutic modality for the management of vascular malformations. The purpose of this case series is to describe our clinical experience of using sodium tetradecyl sulphate (STS) 3 % in the treatment of venous malformation lesions of head and neck. Materials and Methods Thirteen patients were included in this study (three male and ten female; age range between 8 months and 54 years; mean age 18.2 years, ±SD 15.71). The patients were treated by 3 % STS intralesional injections. Of the thirteen patients treated, complete resolution occurred in four patients (28.57 %), a good response occurred in five patients (35.7 %), a moderate response in two patients (14.28 %), a mild response in two patients (14.28 %) and no response in one patient (7.14 %). The side effects encountered in all patients were pain and edema after injection which was controlled by oral analgesics and an intramuscular injection of dexamethasone. In addition, two patients developed a superficial ulceration (11.76 %) which healed uneventfully, and one patient developed ecchymosis after injection (5.88 %). Conclusion Sclerotherapy with 3 % STS is a simple, safe, and effective modality for the treatment of venous malformations.

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Section: Discussionmentioning

confidence: 99%

The Use of Sodium Tetradecyl Sulphate for the Treatment of Venous Malformations of the Head and Neck

Alakailly

Kummoona

Quereshy

et al. 2014

J. Maxillofac. Oral Surg.

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“…Bleomycin injection is generally safe, with reversible complications such as fever and vomiting. One patient (3%) suffered from skin ulceration, but in a larger series of 249 and 66 patients, no ulceration was reported (13,16). We report a high degree of success, with 96% of hemangiomas cured or substantially reduced.…”

Section: Discussionmentioning

confidence: 61%

“…The mechanism of action of bleomycin involves swelling of endotheial cells and discontinuation of tunica intima with increased thickness of the walls leading to narrowing of the lumen and ultimately occlusion (6,13). Proper injections into the vascular spaces leads to gradual fibrous degeneration and resultant lesion regression, with no fibrosis and scarring.…”

Section: Discussionmentioning

confidence: 99%

“…Proper injections into the vascular spaces leads to gradual fibrous degeneration and resultant lesion regression, with no fibrosis and scarring. It is a minimally invasive treatment with good results, and has therefore been in use for last two decades (2,3,9,13,28,33).…”

Section: Discussionmentioning

confidence: 99%

“…In accordance with the published guidelines, the bleomycin dose was calculated at 0.5-1 mg / kg of body weight, with a maximum of 15 mg per session and 40mg per patient (13).…”

Section: Methodsmentioning

confidence: 99%

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Ultrasound-guided Intralesional Bleomycin Injection (IBI) for Treatment of Cutaneous Hemangiomas and Vascular Malformations

Memon

Malik

Anjum

et al. 2016

JGR

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Purpose: To report the therapeutic outcome of ultrasound-guided intralesional injection of bleomycin in the treatment of cutaneous hemangiomas and vascular malformations. Material & Methods:The medical records of patients with cutaneous hemangiomas and vascular malformations treated with the intralesional injection of bleomycin under ultrasound guidance between August 2009 and June 2013 at the Indus Hospital, Karachi were reviewed retrospectively using a computerized medical record information management system. Data were extracted using a pre-coded performa that included patient demographics, type and location of lesion, number of treatments, presenting/pre-and post-treatment clinical symptoms (pain, swelling, heaviness, size, discoloration), ultrasound appearance and vascularity, and post-treatment side effects. The dose range of bleomycin was 0.5-1.0 mg/kg, but not exceeding 15 mg in a single session. A maximum of four treatments were given in any given patient except for one, who presented with recurrence after a year of complete resolution. Therapeutic outcome was determined using review of ultrasound images and recorded clinical assessment. Treatment response was categorized as: (i) complete resolution [more than 90% reduction]; (ii) substantial reduction [more than 50% reduction]; (iii) mild reduction [25% reduction]; or, (iv) no improvement [<10% reduction].Results: A total of 30 patients (16 female, 14 male), ranging in age from 8 months to 48 years (mean age 10.2 years), were treated from 2009 to 2013. There were 23 hemangiomas. Seven were vascular malformations, of which five were lymphatic malformations and two were venous malformations. Twenty-eight lesions were located in the head and neck region, and two were peripheral. In 24 of the 30 patients (76%), treatment had been completed. In six patients (21%) treatment was ongoing at the time of this report. Seventeen of the 23 hemangiomas (74%) were completely resolved clinically and on ultrasound, five (22%) showed substantial improvement and one (4%) showed mild improvement. In five of the seven vascular malformations (71%) lymphatic malformations resolved completely, and two (29%) venous malformations showed substantial improvement. Of the 13 patients presenting with discoloration, there was complete resolution in one (7.7%), marked reduction in 11 (84.6%) and mild reduction in one (7.7%). Of seven patients presenting with pain, there was complete resolution in two (28.6%), marked reduction in two (28.6%), mild reduction in two (28.6%), and no improvement in one (14.3%). There were no pulmonary complications. Conclusion:Ultrasound-guided intralesional injection of bleomycin is an option to consider for the treatment of certain types of cutaneous hemangiomas and vascular malformations. Prospective studies should be undertaken to understand the various factors contributing to therapeutic success. Ultrasound-guided Intralesional Bleomycin Injection (IBI) for Treatment of Cutaneous Hemangiomas and Vascular Malformations

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Pingyangmycin as First-Line Treatment for Low-Flow Orbital or Periorbital Venous Malformations

Jia

Huang

et al. 2014

JAMA Ophthalmol

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Intralesional injection of Pingyangmycin for vascular malformations in oral and maxillofacial regions: An evaluation of 297 consecutive patients

Cited by 73 publications

References 15 publications

The Use of Sodium Tetradecyl Sulphate for the Treatment of Venous Malformations of the Head and Neck

The Use of Sodium Tetradecyl Sulphate for the Treatment of Venous Malformations of the Head and Neck

Ultrasound-guided Intralesional Bleomycin Injection (IBI) for Treatment of Cutaneous Hemangiomas and Vascular Malformations

Pingyangmycin as First-Line Treatment for Low-Flow Orbital or Periorbital Venous Malformations

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