Intralesional bevacizumab (Avastin<sup>®</sup>) as a novel addition to infantile hemangioma management: A medical hypothesis

Pourazizi, Mohsen; Kabiri, Sattar; Abtahi‐Naeini, Bahareh

doi:10.4103/jrpp.jrpp_17_38

Cited by 3 publications

(2 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Bevacizumab is used in treating certain types of cancer, including colon or lung cancer, affecting adults (9). Treatment of patients with hemangiomas has not been studied extensively (10).…”

Section: Introductionmentioning

confidence: 99%

Combined effect of propranolol, vincristine and bevacizumab on HUVECs and BJ cells

et al. 2018

View full text Add to dashboard Cite

Infantile hemangioma is one of the most common benign tumors affecting children, with ~10–15% requiring medical treatment. These tumors consist of endothelial cells and stromal components, including fibroblasts, pericytes and mast cells. Effects of propranolol treatment in combination with bevacizumab or vincristine on cell growth were compared in the current study using human umbilical vein endothelial cells (HUVECs) and BJ human normal fibroblasts (BJs) to determine potential synergic effects in vitro. Inhibition of cell growth was investigated using MTT assays and cytotoxicity of the drugs in various combinations was expressed as half inhibitory concentration (IC50). Apoptosis was investigated using flow cytometry, with Alexa Fluor 488 and propidium iodide. Propranolol inhibited BJ and HUVEC growth in a dose-dependent manner, with increased response observed in BJs (IC50, 148,32 µg/ml; standard error logIC50, 0.07). Treatment with vincristine induced the strongest growth inhibition in HUVECs (IC50, 17,89 µg/ml; standard error log IC50, 0.07) and BJs (IC50, 24,81 µg/ml; standard error log IC50, 0.08) compared with propranolol (HUVEC IC50, 81,94 µg/ml; standard error log IC50, 0.06; BJ-IC50, 148,32 µg/ml; standard error logIC50, 0.07) or bevacizumab (HUVEC IC50 96,91 µg/ml; standard error log IC50, 0.06; BJ IC50, 182,70 µg/ml; standard error log IC50, 0.09) alone. Bevacizumab was the weakest cytotoxic agent. Combination treatment of vincristine with bevacizumab induced the highest levels of apoptosis in HUVECs compared with all other treatments and triple-drug therapy induced the levels of apoptosis in BJs. Single treatment with vincristine, propranolol or bevacizumab induced apoptosis in BJs and HUVECs. In BJs, triple treatment exhibited the greatest influence on apoptosis, compared with single and dual treatments and in HUVECs, vincristine and bevacizumab combination treatment induced apoptosis to the highest level. The present study offers novel perspectives in drug repurposing studies for the three drugs, particularly in diseases where the pathogenesis is based on healthy endothelial cell proliferation, including hemangiomas.

show abstract

Section: Introductionmentioning

confidence: 99%

Combined effect of propranolol, vincristine and bevacizumab on HUVECs and BJ cells

et al. 2018

View full text Add to dashboard Cite

show abstract

“…Furthermore, it has local anti-VEGF properties. [7] Altering the VEGF activity in keloids seems to help the improvement of a vascular portion of keloid and may also prove helpful in keloid lesion. In conclusion, it can be presented as a hypothesis to utilize the local bevacizumab as a promising agent for keloid management.…”

mentioning

confidence: 99%

Promising novel treatment against keloids: Antivascular endothelial growth factor agents

2019

Self Cite

View full text Add to dashboard Cite

Infantile Hemangioma: A Review of Current Pharmacotherapy Treatment and Practice Pearls

Tiemann¹,

Hein²

2020

The Journal of Pediatric Pharmacology and Therapeutics

View full text Add to dashboard Cite

Infantile hemangioma (IH) is the most common vascular tumor of infancy, affecting as many as 5% to 10% of all infants. The exact cause is unclear, but specific risk factors, such as low birth weight, prematurity, female sex, white race, and family history are associated with IH development. Most IHs are benign and self-resolving, but a small subset of patients with IHs are at risk of severe or life-threatening outcomes. Systemic and topical β-blockers are effective and safe for use in pediatric patients and considered first-line treatment for both complicated and uncomplicated IHs. Recently published guidelines provide a thorough review of IH and management. This article focuses on IH pharmacotherapy and provides practice pearls to support health care providers in IH medication management.

show abstract

Intralesional bevacizumab (Avastin^®) as a novel addition to infantile hemangioma management: A medical hypothesis

Cited by 3 publications

References 12 publications

Combined effect of propranolol, vincristine and bevacizumab on HUVECs and BJ cells

Combined effect of propranolol, vincristine and bevacizumab on HUVECs and BJ cells

Promising novel treatment against keloids: Antivascular endothelial growth factor agents

Infantile Hemangioma: A Review of Current Pharmacotherapy Treatment and Practice Pearls

Contact Info

Product

Resources

About

Intralesional bevacizumab (Avastin®) as a novel addition to infantile hemangioma management: A medical hypothesis

Cited by 3 publications

References 12 publications

Combined effect of propranolol, vincristine and bevacizumab on HUVECs and BJ cells

Combined effect of propranolol, vincristine and bevacizumab on HUVECs and BJ cells

Promising novel treatment against keloids: Antivascular endothelial growth factor agents

Infantile Hemangioma: A Review of Current Pharmacotherapy Treatment and Practice Pearls

Contact Info

Product

Resources

About

Intralesional bevacizumab (Avastin^®) as a novel addition to infantile hemangioma management: A medical hypothesis