Intralesional antigen immunotherapy for the treatment of plane warts: A comparative study

Fawzy, Mohamed M.; Nofal, Ahmad; Alakad, Rania

doi:10.1111/dth.13807

Cited by 10 publications

(20 citation statements)

References 18 publications

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“…In the present study, no statistically significant relationship was found between the therapeutic response to intralesional PPD, Candida antigen, MMR, and combined therapy, and the different clinical variables. This was in agreement with many of the related studies that also reported absence of significant associations between the therapeutic response to the injected antigen and most of the clinical variables [ 12 , 23 , 28 ].…”

Section: Discussionsupporting

confidence: 92%

“…[ 27 ] (63%) and Fawzy et al. [ 28 ] (62.5%), higher than that reported by Shaker et al. [ 29 ] (30% cure rate), and lower than that reported by Eldahshan et al.…”

Section: Discussionmentioning

confidence: 78%

“…This recurrence rate is relatively higher than that observed in most of the related studies. [ 12 , 23 , 28 ]. This may be attributed to the different baseline characteristics and the recalcitrant nature of warts in this study.…”

Section: Discussionmentioning

confidence: 99%

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Triple Intralesional Antigen Immunotherapy versus Monoantigen in the Treatment of Multiple Recalcitrant Warts

Nofal

Elkholy

Abd-Elmonsef

et al. 2022

Dermatol Ther (Heidelb)

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Introduction Warts can be resistant to treatment or recur despite the use of various destructive and immunotherapeutic modalities. Combination immunotherapy might contribute to better response rates. The aim of this study was to assess the effectiveness and safety of a triple intralesional immunotherapy combination composed of purified protein derivative (PPD), Candida antigen, and measles–mumps–rubella vaccine (MMR), versus each agent alone, in the management of multiple recalcitrant warts. Methods In total, 160 patients with numerous resistant extragenital warts were included in the research. They were randomly assigned to one of four groups (each with 40 patients): PPD, Candida antigen, and MMR, or combination of the three antigens. Injections into the biggest wart were repeated every 2 weeks until clearance or for a total of five sessions. Results Complete wart clearance was reported in 31 patients (77.5%) who received triple-antigen immunotherapy, 23 patients (57.5%) who received intralesional PPD, 29 patients (72.5%) injected with Candida antigen, and 25 patients (62.5%) who received MMR. The combined therapy was found to be superior to the other therapies and had the lowest recurrence rate, but the difference was not statistically significant. Conclusions Triple intralesional antigen immunotherapy is as safe as, and more effective than, monoantigen immunotherapy, and can be added to the armamentarium against recalcitrant human papilloma virus (HPV) infections.

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Section: Discussionsupporting

confidence: 92%

“…[ 27 ] (63%) and Fawzy et al. [ 28 ] (62.5%), higher than that reported by Shaker et al. [ 29 ] (30% cure rate), and lower than that reported by Eldahshan et al.…”

Section: Discussionmentioning

confidence: 78%

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Triple Intralesional Antigen Immunotherapy versus Monoantigen in the Treatment of Multiple Recalcitrant Warts

Nofal

Elkholy

Abd-Elmonsef

et al. 2022

Dermatol Ther (Heidelb)

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“…Also, flu‐like symptoms were presented in 2 (5%) patients of the PPD group, 6 (15%) patients of the Candida albicans antigen group, and 3 (7.5%) patients of the MMR group. No recurrence of the warts was noticed after a 6‐month follow‐up period in the Candida albicans antigen and MMR groups, although it was recorded in 3 (7.5%) patients of those treated with PPD 22 …”

Section: Discussionmentioning

confidence: 85%

Possible clinical efficacy and tolerability of platelet‐rich plasma in the treatment of patients with recalcitrant plane warts: The first clinical study

El‐Hamd

Aboeldahab

2021

J of Cosmetic Dermatology

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Cutaneous warts are infectious diseases of keratinocytes, caused by different serotypes of human papillomavirus. Its prevalence enhances during childhood to establish a maximum peak in adolescence and adulthood; then it decreases speedily throughout the 20s and progressively afterward. 1 Plane warts are mainly caused by HPV serotypes 3, 10, 28, and 41, presenting mainly in children and young adults. They present as smooth, slightly elevated, or flat papules, commonly skin-colored,

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“…Studies have reported adverse local inflammatory reactions in 31% of patients when imiquimod cream was applied, 8 and blistering in 95% of patients when cantharidin 0.7% solution was applied 9 . Intralesional antigen immunotherapy is an emerging treatment, with a cure rate reaching 59.37% to 62.50%, while 13.33% of patients suffer from influenza‐like illness, and more than 50% experience hyperpigmentation, indurated nodules and scars accompanied by a recurrence rate of at least 30% 10,11 . Photodynamic therapy (PDT) has an effective rate of 57.5% 12 .…”

Section: Introductionmentioning

confidence: 99%

A multi center real world observation to evaluate the efficacy of cryotherapy versus local hyperthermia for the treatment of plane warts

Zhao

Huo

et al. 2022

Dermatologic Therapy

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Most plane warts are recalcitrant to treatment. Both cryotherapy and local hyperthermia have been applied to treat plane warts. However, no direct comparative study on their respective efficacy and safety has ever been performed. To assess the efficacy and safety of local hyperthermia at 43 ± 1°C versus liquid nitrogen cryotherapy for plane warts. Sequential patients with plane warts entered the study, either receiving cryotherapy or local hyperthermia therapy at the discretion of the patients and the recommendations of consultants. Cryotherapy with liquid nitrogen was delivered in two sessions 2 weeks apart, while local hyperthermia was delivered on three consecutive days, plus two similar treatments 10 ± 3 days later. The temperature over the treated skin surface was set at 43 ± 1°C for 30 min in each session. The primary outcome was the clearance rates of the lesions 6 months after treatment. Among the 194 participants enrolled, 183 were included in the analysis at 6 months. Local hyperthermia and cryotherapy achieved clearance rates of 35.56% (48/135) and 31.25% (15/48), respectively (p = 0.724); recurrence rates of 16.67% (8/48) and 53.33% (8/15) (p = 0.01); and adverse events rates of 20.74% (28/135) and 83.33% (40/48), respectively (p < 0.001). Cryotherapy had a higher pain score (p < 0.001) and a longer healing time (p < 0.001). Local hyperthermia at 43°C and cryotherapy had similar efficacy for plane warts. Local hyperthermia had a safer profile than cryotherapy but it required more treatment visits during a treatment course. More patients preferred local hyperthermia due to its treatment friendly nature.

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Intralesional antigen immunotherapy for the treatment of plane warts: A comparative study

Cited by 10 publications

References 18 publications

Triple Intralesional Antigen Immunotherapy versus Monoantigen in the Treatment of Multiple Recalcitrant Warts

Triple Intralesional Antigen Immunotherapy versus Monoantigen in the Treatment of Multiple Recalcitrant Warts

Possible clinical efficacy and tolerability of platelet‐rich plasma in the treatment of patients with recalcitrant plane warts: The first clinical study

A multi center real world observation to evaluate the efficacy of cryotherapy versus local hyperthermia for the treatment of plane warts

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