Intrahippocampal injection of TsTX-I, a beta-scorpion toxin, causes alterations in electroencephalographic recording and behavior in rats

Abstract

The results suggest that TsTX-I toxin may be responsible, at least in part, for the epileptic and behavioral effects observed with the crude venom, and although veratridine and TsTX-I act on Na-channel, the differences between them are remarkable, demonstrating that toxins can have different functional effects depending on the site of action in the channel. Thus, animal neurotoxins are often highly selective and may be useful for the identification of the sequence of events underlying neurotransmission.

Systemic toxic effects induced by the aqueous extract of the fire coral Millepora complanata and partial purification of thermostable neurotoxins with lethal effects in mice

“…The very little spectrometric and spectroscopic information allowed us to propose a generic structure of IIA-2-2. in rats and mice (Nencioni et al, 2000;Lourenço et al, 2002;Cunha et al, 2005;Teixeira et al, 2010;Caliskan et al, 2012).…”

Pro- and Anticonvulsant Effects of the Ant Dinoponera quadriceps (Kempf) Venom in Mice

“…For example, the BmK I, an alpha-like scorpion neurotoxin isolated from the venom of Buthus martensi Karsch, induced seizures in rats by intrahippocampal administration (Bai et al 2006). Moreover, the TsTX-I, a scorpion neurotoxin isolated from T. serrulatus venom, promoted short and long epileptic-like discharges when injected in the hippocampus of rats (Teixeira et al 2010).…”

Serrumab: A novel human single chain-fragment antibody with multiple scorpion toxin-neutralizing capacities

“…Because Serrumab was able to inhibit $50% of the effect of the major toxin, we can presume that it would counter some effects of scorpion envenomation. Other authors have shown that Ts1 plays an essential role in envenomation (Bertazzi et al, 2003;Correa et al, 1997;Teixeira et al, 2010;Vasconcelos et al, 2005).…”