Intrahepatic sarcomatoid cholangiocarcinoma

Sintra, Sara; Costa, Rui Alves; Filipe, Carlos; Simão, Adélia

doi:10.1136/bcr-2018-225017

Cited by 13 publications

(19 citation statements)

References 13 publications

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“…After analysis of the retrieved publications, 51 unrepeated S-iCCA cases were identified in 20 published studies. 1,2,[5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22] Table 1 summarizes the clinical characteristics of 52 patients (including this case). Thirty-five were male (67.3%), 17 were female (32.7%), and the average age was 61 (range: 37-87) years.…”

Section: Discussionmentioning

confidence: 99%

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Sarcomatoid Intrahepatic Cholangiocarcinoma After Immunotherapy: A Case Report and Review of the Literature

Zeng¹,

Liu²,

Yu³

et al. 2022

J Clin Transl Hepatol

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Sarcomatoid carcinoma is a rare tumor that is composed of a mixture of malignant epithelial cells and mesenchymal cells. Many studies have reported that sarcomatoid carcinoma occurs in multiple organs including the liver. Sarcomatoid intrahepatic cholangiocarcinoma (S-iCCA) is an extremely rare tumor that primarily occurs in the liver. This case occurred in a middle-aged man who was admitted to our hospital with abdominal pain. Enhanced computed tomography of the abdomen showed a low-density mass in the upper right posterior lobe of the liver with enhancement in the periphery. Histological and immunohistochemical examination indicated that the tumor was malignant, with both cancer and sarcoma components, and was positive for cytokeratin and vimentin. The patient was diagnosed with S-iCCA. Metastases appeared in the liver and lung 4 months after surgery. Two cycles of chemotherapy were administered. Because of enlargement of the tumor, anti-angiogenic agents combined with immunotherapy were subsequently given to achieve disease control. To the best of our knowledge, this is the first reported case of a programmed cell death-1 inhibitor used in a S-iCCA patient. The purpose of this case report and literature review is to enhance clinician understanding of S-iCCA and to explore safe and effective treatment methods.

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Section: Discussionmentioning

confidence: 99%

“…The former is not sensitive to radiotherapy and chemotherapy, and the survival rate is extremely low, with 1-year overall survival at almost zero. 8,22 Based on this context, more treatment options urgently need to be developed and updated.…”

Section: Discussionmentioning

confidence: 99%

Sarcomatoid Intrahepatic Cholangiocarcinoma After Immunotherapy: A Case Report and Review of the Literature

Zeng¹,

Liu²,

Yu³

et al. 2022

J Clin Transl Hepatol

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“…Moreover, prognosis is poor in comparison to other liver cancers. Most commonly, adults over 40 who are middle aged or older develop intrahepatic sarcomatoid cholangiocarcinoma [5]. Imaging results can frequently be confused with hepatocellular carcinoma or other similar malignancies.…”

Section: Introductionmentioning

confidence: 99%

Intrahepatic sarcomatoid cholangiocarcinoma with portal vein thrombus misdiagnosed as hepatocellular carcinoma: description of a rare case

Zhan

Xing

2023

Preprint

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Less than 1% of malignant tumors of the hepatobiliary system are intrahepatic sarcomatoid cholangiocarcinomas, a rare malignant tumor of the liver. Based only on clinical presentation and imaging, this entity is readily mistaken for hepatocellular carcinoma. In this article, we describe the case of a 36-year-old male patient who had a history of "cirrhosis B" and was hospitalized for six months due to increased alpha-fetoprotein. Magnetic resonance imaging (MRI) and computed tomography (CT) revealed a 63x 90 mm mass in segments V and VI of the liver, with thrombosis in the right branch of the portal vein. Following the patient's laparoscopic lobectomy and cholecystectomy, sarcomatoid cholangiocarcinoma of the right side of the liver was discovered by histopathological and immunohistochemical examinations. This case report seeks to increase understanding of intrahepatic sarcomatoid cholangiocarcinoma and its diagnosis while reducing the occurrence of clinical misinterpretation.

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“…Intrahepatic sarcomatoid cholangiocarcinoma is also most commonly characterized by fever and abdominal pain and since it is easily confused with hepatocellular carcinoma and other liver tumors, immunohistochemical staining is required for an accurate diagnosis. Although middle-aged and elderly individuals over 40 years old are considered to be the main high-risk group of s-CCC ( 7 ), in this study, the case of a 32-year-old patient, diagnosed with the condition, is described. A discussion of relevant literature is also undertaken in view of improving the awareness, diagnosis, and treatment of s-CCC.…”

Section: Introductionmentioning

confidence: 99%

Intrahepatic sarcomatoid cholangiocarcinoma: A case report of the youngest patient on record and a review of the condition's characteristics

Longfu

Jin

2022

Front. Surg.

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As a rare disease, intrahepatic sarcomatoid cholangiocarcinoma (s-CCC) represents less than 1% of malignancies of the hepatobiliary system and its main clinical symptoms include abdominal pain and fever. Results of pathological examinations, despite being the “gold standard”, can easily be confused with hepatocellular carcinoma (HCC). This report is about a 32-year-old male patient who was hospitalized due to occupancy of segment V of the liver for three days and had a history of chronic hepatitis B (CHB) over a 20-year span. Magnetic resonance imaging (MRI) showed a 43 mm × 52 mm-sized liver mass in the V segment, with patchy peripheral enhancement during the arterial phase and rapid wash-out during the portal and late phases. A laparoscopic hepatectomy of segment V, along with cholecystectomy, was performed. Histopathological and immunohistochemical examinations indicated a malignant neoplasm that was positive for vimentin and cytokeratin, with these features providing a positive diagnosis for intrahepatic sarcomatoid cholangiocarcinoma. After surgery, an adjuvant therapy of albumin-paclitaxel combined with gemcitabine regimen was given. No recurrence was found six months after the surgery, with follow-up still ongoing. This report aims to improve the awareness, diagnosis, and treatment of s-CCC.

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Intrahepatic sarcomatoid cholangiocarcinoma

Cited by 13 publications

References 13 publications

Sarcomatoid Intrahepatic Cholangiocarcinoma After Immunotherapy: A Case Report and Review of the Literature

Sarcomatoid Intrahepatic Cholangiocarcinoma After Immunotherapy: A Case Report and Review of the Literature

Intrahepatic sarcomatoid cholangiocarcinoma with portal vein thrombus misdiagnosed as hepatocellular carcinoma: description of a rare case

Intrahepatic sarcomatoid cholangiocarcinoma: A case report of the youngest patient on record and a review of the condition's characteristics

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